The Rutgers University Molecular Imaging Center (RUMIC) is an advanced facility established by the Office of the Vice President for Research and Economic Development and is intended for use primarily by Rutgers faculty. Organizations outside of Rutgers may inquire about using the facility on a fee-for-service basis. The Center offers non-invasive approaches to observe disease states, disease progression and therapeutic responses in living systems and ex vivo organs. Our comprehensive small animal imaging modalities for the basic sciences include Skyscan-Bruker Micro-CT, Aspect 1T MRI, Bruker multi-modality optical/X-ray, Bruker PET/CT, and Visualsonic ultrasound technologies. The approaches used allow researchers the ability to generate multiple, spatially-resolved anatomical, functional, and molecular-level readouts from a single study. The Center provides an animal housing facility for serial imaging, surgery, anesthesia, and veterinary care. Image reconstruction, 3D display, fusion, quantitative image analysis and server access are also available.