Research Output 1964 2019

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2019

A novel antibody-toxin conjugate to treat mantle cell lymphoma

Rather, G. M., Lin, S. Y., Lin, H., Szekely, Z. & Bertino, J., Jan 1 2019, In : Frontiers in Oncology. 9, APR, 258.

Rutgers, The State University

Research output: Contribution to journalArticle

Open Access
Mantle-Cell Lymphoma
Immunotoxins
Heterografts
Cell Line
Neoplasms

Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells

Wang, Y., Xiong, H., Liu, D., Hill, C., Ertay, A., Li, J., Zou, Y., Miller, P., White, E., Downward, J., Goldin, R. D., Yuan, X. & Lu, X., May 4 2019, In : Autophagy. 15, 5, p. 886-899 14 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Open Access
Epithelial-Mesenchymal Transition
Autophagy
TNF Receptor-Associated Factor 6
Neoplasms
RNA Interference
1 Citation (Scopus)

Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1-deficient kras-driven lung tumorigenesis

Bhatt, V., Khayati, K., Hu, Z. S., Lee, A., Kamran, W., Su, X. & Guo, Y., Feb 1 2019, In : Genes and Development. 33, 3-4, p. 150-165 16 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Autophagy
Lipid Metabolism
Carcinogenesis
Lung
Neoplasms

MORC2 regulates C/EBPα-mediated cell differentiation via sumoylation

Liu, J., Zhang, Q., Ruan, B., Chen, W., Zheng, J., Xu, B., Jiang, P., Miao, Z., Li, F., Guo, Y., Cao, L. & Wang, G., Jan 1 2019, (Accepted/In press) In : Cell Death and Differentiation.

Rutgers, The State University

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Sumoylation
Cell Differentiation
Zinc Fingers
Stomach Neoplasms
5 Citations (Scopus)

Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids

Neinast, M. D., Jang, C., Hui, S., Murashige, D. S., Chu, Q., Morscher, R. J., Li, X., Zhan, L., White, E., Anthony, T., Rabinowitz, J. D. & Arany, Z., Feb 5 2019, In : Cell Metabolism. 29, 2, p. 417-429.e4

Rutgers, The State University, Princeton University

Research output: Contribution to journalArticle

Branched Chain Amino Acids
Insulin
Skeletal Muscle
Tricarboxylic Acids
Genetic Suppression
2018
2 Citations (Scopus)

Activated matriptase as a target to treat breast cancer with a drug conjugate

Rather, G. M., Lin, S. Y., Lin, H., Banach-Petrosky, W., Hirshfield, K., Lin, C. Y., Johnson, M. D., Szekely, Z. & Bertino, J., Jan 1 2018, In : Oncotarget. 9, 40, p. 25983-25992 10 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Breast Neoplasms
Antibodies
Heterografts
Pharmaceutical Preparations
23 Citations (Scopus)

Autophagy maintains tumour growth through circulating arginine

Poillet-Perez, L., Xie, X., Zhan, L., Yang, Y., Sharp, D. W., Hu, Z. S., Su, X., Maganti, A., Jiang, C., Lu, W., Zheng, H., Bosenberg, M. W., Mehnert, J., Guo, Y., Lattime, E., Rabinowitz, J. D. & White, E., Nov 1 2018, In : Nature. 563, 7732, p. 569-573 5 p.

Rutgers, The State University, Princeton University

Research output: Contribution to journalArticle

Autophagy
Arginine
Growth
Neoplasms
Essential Genes
4 Citations (Scopus)

Dose intensification of TRAIL-inducing ONC201 inhibits metastasis and promotes intratumoral NK cell recruitment

Wagner, J., Leah Kline, C., Zhou, L., Campbell, K. S., MacFarlane, A. W., Olszanski, A. J., Cai, K. Q., Hensley, H. H., Ross, E. A., Ralff, M. D., Zloza, A., Chesson, C. B., Newman, J. H., Kaufman, H., Bertino, J., Stein, M. & El-Deiry, W. S., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2325-2338 14 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Natural Killer Cells
Neoplasm Metastasis
Neoplasms
TIC10 compound
Cell Migration Inhibition
5 Citations (Scopus)

Four Key Steps Control Glycolytic Flux in Mammalian Cells

Tanner, L. B., Goglia, A. G., Wei, M. H., Sehgal, T., Parsons, L. R., Park, J. O., White, E., Toettcher, J. E. & Rabinowitz, J. D., Jul 25 2018, In : Cell Systems. 7, 1, p. 49-62.e8

Princeton University, Rutgers, The State University

Research output: Contribution to journalArticle

Glycolysis
Lactic Acid
Enzymes
Glucose
Isoenzymes
1 Citation (Scopus)

Modeling and antitumor studies of a modified L-penetratin peptide targeting E2F in lung cancer and prostate cancer

Shaik, T., Rather, G. M., Bansal, N., Minko, T., Garbuzenko, O., Szekely, Z., Abali, E. E., Banerjee, D., Kerrigan, J. E., Scotto, K. & Bertino, J., Sep 1 2018, In : Oncotarget. 9, 70, p. 33249-33257 9 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Lung Neoplasms
Prostatic Neoplasms
Peptides
Heterografts
Cell Line
24 Citations (Scopus)

Quantitative Analysis of NAD Synthesis-Breakdown Fluxes

Liu, L., Su, X., Quinn, W. J., Hui, S., Krukenberg, K., Frederick, D. W., Redpath, P., Zhan, L., Chellappa, K., White, E., Migaud, M., Mitchison, T. J., Baur, J. A. & Rabinowitz, J. D., May 1 2018, In : Cell Metabolism. 27, 5, p. 1067-1080.e5

Rutgers, The State University, Princeton University

Research output: Contribution to journalArticle

NAD
Niacinamide
Sirtuins
Poly(ADP-ribose) Polymerases
Tryptophan
2 Citations (Scopus)

Sirt1 protects from K-Ras-driven lung carcinogenesis

Costa-Machado, L. F., Martín-Hernández, R., Sanchez-Luengo, M. Á., Hess, K., Vales-Villamarin, C., Barradas, M., Lynch, C., de la Nava, D., Diaz-Ruiz, A., de Cabo, R., Cañamero, M., Martinez, L., Sanchez-Carbayo, M., Herranz Benito, D., Serrano, M. & Fernandez-Marcos, P. J., Sep 1 2018, In : EMBO Reports. 19, 9, e43879.

Rutgers, The State University

Research output: Contribution to journalArticle

Tumors
Carcinogenesis
Lung
Cells
Neoplasms
2 Citations (Scopus)

SMAD4 suppresses WNt-driven dedifferentiation and oncogenesis in the differentiated gut epithelium

Perekatt, A. O., Shah, P. P., Cheung, S., Jariwala, N., Wu, A., Gandhi, V., Kumar, N., Feng, Q., Patel, N., Chen, L., Joshi, S., Zhou, A., Taketo, M. M., Xing, J., White, E., Gao, N., Gatza, M. & Verzi, M., Sep 1 2018, In : Cancer Research. 78, 17, p. 4878-4890 13 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Carcinogenesis
Epithelium
Intestinal Mucosa
Neoplasms
Enterocytes
17 Citations (Scopus)

SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation

Tsang, C. K., Chen, M., Cheng, X., Qi, Y., Chen, Y., Das, I., Li, X., Vallat, B., Fu, L. W., Qian, C. N., Wang, H. Y., White, E., Burley, S. & Zheng, X. F. S., May 3 2018, In : Molecular cell. 70, 3, p. 502-515.e8

Rutgers, The State University

Research output: Contribution to journalArticle

Oxidation-Reduction
Phosphorylation
Food
Reactive Oxygen Species
Cell Survival
6 Citations (Scopus)
Drug Discovery
Glioblastoma
Heterografts
Neoplasms
Therapeutics
6 Citations (Scopus)

Zinc metallochaperones reactivate mutant p53 using an on/off switch mechanism: A new paradigm in cancer therapeutics

Yu, X., Kogan, S., Chen, Y., Tsang, A. T., Withers, T., Lin, H., Gilleran, J., Buckley, B., Moore, D., Bertino, J., Chan, C., Kimball, S., Loh, S. N. & Carpizo, D., Sep 15 2018, In : Clinical Cancer Research. 24, 18, p. 4505-4517 13 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Metallochaperones
Zinc
Neoplasms
Therapeutics
Pharmacokinetics
2017
11 Citations (Scopus)

BRAF fusion as a novel mechanism of acquired resistance to vemurafenib in BRAFV600E mutant melanoma

Kulkarni, A., Al-Hraishawi, H., Simhadri, S., Hirshfield, K., Chen, S., Pine, S., Jeyamohan, C., Sokol, L., Ali, S., Teo, M. L., White, E., Rodriguez-Rust, L., Mehnert, J. & Ganesan, S., Sep 15 2017, In : Clinical Cancer Research. 23, 18, p. 5631-5638 8 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Melanoma
Gene Fusion
Mitogen-Activated Protein Kinase Kinases
Mutation
PLX4032
28 Citations (Scopus)

First-in-human clinical trial of oral ONC201 in patients with refractory solid tumors

Stein, M., Bertino, J., Kaufman, H. L., Mayer, T., Moss, R., Silk, A., Chan, N., Malhotra, J., Rodriguez-Rust, L., Aisner, J., Aiken, R., Haffty, B., DiPaola, R. S., Saunders, T., Zloza, A., Damare, S., Beckett, Y., Yu, B., Najmi, S., Gabel, C. & 7 othersDickerson, S., Zheng, L., El-Deiry, W. S., Allen, J. E., Stogniew, M., Oster, W. & Mehnert, J., Aug 1 2017, In : Clinical Cancer Research. 23, 15, p. 4163-4169 7 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Clinical Trials
Neoplasms
Pharmacokinetics
Keratin-18
Endometrial Neoplasms
4 Citations (Scopus)

Gamma secretase inhibition by BMS-906024 enhances efficacy of paclitaxel in lung adenocarcinoma

Morgan, K. M., Fischer, B. S., Lee, F. Y., Shah, J. J., Bertino, J., Rosenfeld, J., Singh, A., Khiabanian, H. & Pine, S., Dec 1 2017, In : Molecular Cancer Therapeutics. 16, 12, p. 2759-2769 11 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
Paclitaxel
Non-Small Cell Lung Carcinoma
Cell Line
BMS-906024
133 Citations (Scopus)

Glucose feeds the TCA cycle via circulating lactate

Hui, S., Ghergurovich, J. M., Morscher, R. J., Jang, C., Teng, X., Lu, W., Esparza, L. A., Reya, T., Zhan, L., Yanxiang Guo, J., White, E. & Rabinowitz, J. D., Nov 2 2017, In : Nature. 551, 7678, p. 115-118 4 p.

Princeton University, Rutgers, The State University

Research output: Contribution to journalArticle

Citric Acid Cycle
Lactic Acid
Glucose
Glycolysis
Pancreatic Neoplasms
1 Citation (Scopus)

Impaired Autophagy and Defective T Cell Homeostasis in Mice with T Cell-Specific Deletion of Receptor for Activated C Kinase 1

Qiu, G., Liu, J., Cheng, Q., Wang, Q., Jing, Z., Pei, Y., Zhao, M., Wang, J., Guo, Y. & Zhang, J., May 18 2017, In : Frontiers in immunology. 8, MAY, 575.

Rutgers, The State University

Research output: Contribution to journalArticle

Autophagy
Homeostasis
T-Lymphocytes
Regulatory T-Lymphocytes
Liver
3 Citations (Scopus)

Regulation of spindle integrity and mitotic fidelity by BCCIP

Huhn, S. C., Liu, J., Ye, C., Lu, H., Jiang, X., Feng, X., Ganesan, S., White, E. & Shen, Z., Apr 10 2017, (Accepted/In press) In : Oncogene.

Rutgers, The State University

Research output: Contribution to journalArticle

Spindle Apparatus
Spindle Poles
Centrosome
Microtubules
Chromosomes
5 Citations (Scopus)

Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity

Kimani, S. G., Kumar, S., Bansal, N., Singh, K., Kholodovych, V., Comollo, T., Peng, Y., Kotenko, S., Sarafianos, S. G., Bertino, J., Welsh, W. & Birge, R., Mar 8 2017, In : Scientific reports. 7, 43908.

Rutgers, The State University

Research output: Contribution to journalArticle

Growth Inhibitors
Growth
Neoplasms
Inbred NOD Mouse
Neoplasm Staging
9 Citations (Scopus)

Synergistic antileukemic therapies in NOTCH1-induced T-ALL

Sanchez-Martin, M., Ambesi-Impiombato, A., Qin, Y., Herranz Benito, D., Bansal, M., Girardi, T., Paietta, E., Tallman, M. S., Rowe, J. M., De Keersmaecker, K., Califano, A. & Ferrando, A. A., Feb 21 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 8, p. 2006-2011 6 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Protein Biosynthesis
Amyloid Precursor Protein Secretases
Therapeutics
Phosphorylation
2 Citations (Scopus)

Synthesis and Characterization of Novel BMI1 Inhibitors Targeting Cellular Self-Renewal in Hepatocellular Carcinoma

Bartucci, M., Hussein, M. S., Huselid, E., Flaherty, K., Patrizii, M., Laddha, S. V., Kui, C., Bigos, R. A., Gilleran, J. A., El Ansary, M. M. S., Awad, M. A. M., Kimball, S., Augeri, D. & Sabaawy, H., Aug 1 2017, In : Targeted Oncology. 12, 4, p. 449-462 14 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Hepatocellular Carcinoma
Neoplasms
Stem Cells
Recurrence
2016
27 Citations (Scopus)

Atg7 cooperates with Pten loss to drive prostate cancer tumor growth

Santanam, U., Banach-Petrosky, W., Abate-Shen, C., Shen, M. M., White, E. & Dipaola, R. S., Feb 15 2016, In : Genes and Development. 30, 4, p. 399-407 9 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Autophagy
Prostatic Neoplasms
Growth
Neoplasms
Prostate
42 Citations (Scopus)

Autophagy, metabolism, and cancer

Guo, Y. & White, E., Jan 1 2016, In : Cold Spring Harbor symposia on quantitative biology. 81, 1, p. 73-78 6 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Autophagy
Metabolism
Mitochondria
Cells
Tumors
46 Citations (Scopus)

Autophagy and p53

White, E., Apr 1 2016, In : Cold Spring Harbor Perspectives in Medicine. 6, 4, a026120.

Rutgers, The State University

Research output: Contribution to journalArticle

Autophagy
Tissue
Quality control
Tumors
Chemical activation
60 Citations (Scopus)

Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells

Guo, Y., Teng, X., Laddha, S. V., Ma, S., Van Nostrand, S. C., Yang, Y., Khor, S., Chan, C., Rabinowitz, J. D. & White, E., Aug 1 2016, In : Genes and Development. 30, 15, p. 1704-1717 14 p.

Rutgers, The State University, Princeton University

Research output: Contribution to journalArticle

Autophagy
Lung Neoplasms
Nucleotides
Starvation
Mitochondria
5 Citations (Scopus)

AYY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis

Kumar, N., Srivillibhuthur, M., Joshi, S., Walton, K. D., Zhou, A., Faller, W. J., Perekatt, A. O., Sansom, O. J., Gumucio, D. L., Xing, J., Bonder, E., Gao, N., White, E. & Verzi, M., Oct 15 2016, In : Development (Cambridge). 143, 20, p. 3711-3722 12 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Organogenesis
Oxidative Phosphorylation
Yin-Yang
Intestines
Pregnancy
19 Citations (Scopus)

BMI-1 targeting interferes with patient-derived tumor-initiating cell survival and tumor growth in prostate cancer

Bansal, N., Bartucci, M., Yusuff, S., Davis, S., Flaherty, K., Huselid, E., Patrizii, M., Jones, D., Cao, L., Sydorenko, N., Moon, Y. C., Zhong, H., Medina, D., Kerrigan, J., Stein, M., Kim, I., Davis, T. W., DiPaola, R. S., Bertino, J. & Sabaawy, H., Dec 15 2016, In : Clinical Cancer Research. 22, 24, p. 6176-6191 16 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Prostatic Neoplasms
Cell Survival
Growth
Neoplasms
19 Citations (Scopus)

Clinical actionability of comprehensive genomic profiling for management of rare or refractory cancers

Hirshfield, K., Tolkunov, D., Zhong, H., Ali, S. M., Stein, M., Murphy, S., Vig, H., Vazquez, A., Glod, J., Moss, R. A., Belyi, V., Chan, C., Chen, S., Goodell, L., Foran, D., Yelensky, R., Palma, N. A., Sun, J. X., Miller, V. A., Stephens, P. J. & 10 othersRoss, J. S., Kaufman, H., Poplin, E., Mehnert, J., Tan, A. R., Bertino, J., Aisner, J., DiPaola, R. S., Rodriguez-Rodriguez, L. & Ganesan, S., Nov 1 2016, In : Oncologist. 21, 11, p. 1315-1325 11 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Neoplasms
Histology
Proto-Oncogene Proteins c-akt
Genetic Testing
Receptor Protein-Tyrosine Kinases
13 Citations (Scopus)

Elevated p62/SQS TM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide

Wang, C., Chen, S., Yeo, S., Karsli-Uzunbas, G., White, E., Mizushima, N., Virgin, H. W. & Guan, J. L., Jan 1 2016, In : Journal of Cell Biology. 212, 5, p. 545-560 16 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Neural Stem Cells
Autophagy
Superoxides
Biological Phenomena
Gene Knockout Techniques
20 Citations (Scopus)

Functional annotation of rare gene aberration drivers of pancreatic cancer

Tsang, Y. H., Dogruluk, T., Tedeschi, P. M., Wardwell-Ozgo, J., Lu, H., Espitia, M., Nair, N., Minelli, R., Chong, Z., Chen, F., Chang, Q. E., Dennison, J. B., Dogruluk, A., Li, M., Ying, H., Bertino, J., Gingras, M. C., Ittmann, M., Kerrigan, J., Chen, K. & 4 othersCreighton, C. J., Eterovic, K., Mills, G. B. & Scott, K. L., Jan 25 2016, In : Nature communications. 7, 10500.

Rutgers, The State University

Research output: Contribution to journalArticle

annotations
Molecular Sequence Annotation
Aberrations
Pancreatic Neoplasms
genes
98 Citations (Scopus)

Immune activation and response to pembrolizumab in POLE-mutant endometrial cancer

Mehnert, J., Panda, A., Zhong, H., Hirshfield, K., Damare, S., Lane, K., Sokol, L., Stein, M., Rodriguez-Rodriquez, L., Kaufman, H. L., Ali, S., Ross, J. S., Pavlick, D. C., Bhanot, G., White, E., DiPaola, R. S., Lovell, A., Cheng, J. & Ganesan, S., Jun 1 2016, In : Journal of Clinical Investigation. 126, 6, p. 2334-2340 7 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Endometrial Neoplasms
Mutation
Programmed Cell Death 1 Receptor
Neoplasms
DNA Polymerase II
3 Citations (Scopus)
Open Access
Organoids
Precision Medicine
Prostatic Neoplasms
Neoplasms
Immunotherapy
13 Citations (Scopus)

SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage

Hong, X., Liu, W., Song, R., Shah, J. J., Feng, X., Tsang, C. K., Morgan, K. M., Bunting, S., Inuzuka, H., Zheng, X. F. S., Shen, Z., Sabaawy, H., Liu, L. X. & Pine, S., Oct 14 2016, In : Nucleic acids research. 44, 18, p. 8855-8869 15 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
DNA Damage
F-Box Proteins
Neoplasms
Epithelial-Mesenchymal Transition
20 Citations (Scopus)

Starving cancer from the outside and inside: Separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumors

Lashinger, L. M., O'Flanagan, C. H., Dunlap, S. M., Rasmussen, A. J., Sweeney, S., Guo, Y., Lodi, A., Tiziani, S., White, E. & Hursting, S. D., Jan 1 2016, In : Cancer and Metabolism. 4, 1, 18.

Rutgers, The State University

Research output: Contribution to journalArticle

Autophagy
Neoplasms
Nude Mice
Diet
Glucose
2015
40 Citations (Scopus)

ABT-199, a BH3 mimetic that specifically targets Bcl-2, enhances the antitumor activity of chemotherapy, bortezomib and JQ1 in "double hit" lymphoma cells

Johnson-Farley, N., Veliz, J., Bhagavathi, S. & Bertino, J., Jan 1 2015, In : Leukemia and Lymphoma. 56, 7, p. 2146-2152 7 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Lymphoma
Drug Therapy
Cell Line
Cytarabine
Doxorubicin
42 Citations (Scopus)

Aneuploidy-induced cellular stresses limit autophagic degradation

Santaguida, S., Vasile, E., White, E. & Amon, A., Oct 1 2015, In : Genes and Development. 29, 19, p. 2010-2021 12 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Aneuploidy
Lysosomes
Gene Expression
Autophagy
Proteasome Endopeptidase Complex
3 Citations (Scopus)

A sensitive liquid chromatography-mass spectrometry bioanalytical assay for a novel anticancer candidate - ZMC1

Lin, H., Yu, X., Eng, O. S., Buckley, B., Kong, A-N., Bertino, J., Carpizo, D. & Gounder, M. K., Nov 1 2015, In : Biomedical Chromatography. 29, 11, p. 1708-1714 7 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Liquid chromatography
Liquid Chromatography
Mass spectrometry
Assays
Mass Spectrometry
61 Citations (Scopus)

Atg7 overcomes senescence and promotes growth of BrafV600E-driven melanoma

Xie, X., Koh, J. Y., Price, S., White, E. & Mehnert, J., Apr 1 2015, In : Cancer Discovery. 5, 4, p. 410-423 14 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Autophagy
Melanoma
Growth
Essential Genes
Neoplasms
14 Citations (Scopus)

Axl receptor tyrosine kinase is up-regulated in metformin resistant prostate cancer cells

Bansal, N., Mishra, P. J., Stein, M., DiPaola, R. S. & Bertino, J., Jan 1 2015, In : Oncotarget. 6, 17, p. 15321-15331 11 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Metformin
Prostatic Neoplasms
docetaxel
Neoplasms
axl receptor tyrosine kinase
12 Citations (Scopus)

Darinaparsin inhibits prostate tumor-initiating cells and Du145 xenografts and is an inhibitor of Hedgehog signaling

Bansal, N., Farley, N. J., Wu, L., Lewis, J., Youssoufian, H. & Bertino, J., Jan 1 2015, In : Molecular Cancer Therapeutics. 14, 1, p. 23-30 8 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Hedgehogs
Neoplastic Stem Cells
Heterografts
Prostate
Prostatic Neoplasms
14 Citations (Scopus)

Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening

Strohecker, A. M., Joshi, S., Possemato, R., Abraham, R. T., Sabatini, D. M. & White, E., Nov 5 2015, In : Oncogene. 34, 45, p. 5662-5676 15 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Phosphofructokinase-2
Autophagy
Small Interfering RNA
Fructose
Reactive Oxygen Species
4 Citations (Scopus)

Intrathecal transplantation of autologous adherent bone marrow cells induces functional neurological recovery in a canine model of spinal cord injury

Gabr, H., El-Kheir, W. A., Farghali, H. A. M. A., Ismail, Z. M. K., Zickri, M. B., El Maadawi, Z. M., Kishk, N. A. & Sabaawy, H., Sep 14 2015, In : Cell Transplantation. 24, 9, p. 1813-1827 15 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Autologous Transplantation
Spinal Cord Injuries
Bone Marrow Cells
Canidae
Bone
5 Citations (Scopus)

LFA-1-targeting Leukotoxin (LtxA; Leukothera®) causes lymphoma tumor regression in a humanized mouse model and requires caspase-8 and Fas to kill malignant lymphocytes

DiFranco, K. M., Johnson-Farley, N., Bertino, J., Elson, D., Vega, B. A., Belinka, B. A. & Kachlany, S., Jun 1 2015, In : Leukemia Research. 39, 6, p. 649-656 8 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Lymphocyte Function-Associated Antigen-1
Caspase 8
Lymphoma
Cell Death
Lymphocytes
1 Citation (Scopus)

Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination

Tedeschi, P. M., Kathari, Y. K., Johnson-Farley, N. & Bertino, J., Jun 26 2015, In : Cancer chemotherapy and pharmacology. 75, 6, p. 1247-1252 6 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Thioguanine
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
T-cells
Heterografts
Bearings (structural)
3 Citations (Scopus)

Nanotechnology applications in hematological malignancies (Review)

Samir, A., Elgamal, B. M., Gabr, H. & Sabaawy, H., Sep 1 2015, In : Oncology reports. 34, 3, p. 1097-1105 9 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Nanotechnology
Hematologic Neoplasms
Neoplasms
Therapeutics
Technology
6 Citations (Scopus)

PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer

Zhang, Y., Wang, X., Qin, X., Wang, X., Liu, F., White, E. & Zheng, X. F. S., Dec 1 2015, In : EBioMedicine. 2, 12, p. 1944-1956 13 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Colorectal Neoplasms
Drug therapy
Signal transduction
Phosphorylation
Biomarkers