Research Output

2020

Autocrine bradykinin release promotes ischemic preconditioning-induced cytoprotection in bovine aortic endothelial cells

Bellis, A., Sorriento, D., Fiordelisi, A., Izzo, R., Sadoshima, J., Mauro, C., Cerasuolo, F., Mancusi, C., Barbato, E., Pilato, E., Trimarco, B. & Morisco, C., Apr 2 2020, In : International journal of molecular sciences. 21, 8, 2965.

Rutgers, The State University

Research output: Contribution to journalArticle

Open Access

Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition

Francisco, J., Zhang, Y., Jeong, J. I., Mizushima, W., Ikeda, S., Ivessa, A., Oka, S., Zhai, P., Tallquist, M. D. & Del Re, D. P., Sep 2020, In : JACC: Basic to Translational Science. 5, 9, p. 931-945 15 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Open Access

Cardiomyopathy in obesity, insulin resistance and diabetes

Nakamura, M. & Sadoshima, J., Jul 1 2020, In : Journal of Physiology. 598, 14, p. 2977-2993 17 p.

Rutgers, The State University

Research output: Contribution to journalArticle

11 Scopus citations

Connexin-43 reduction prevents muscle defects in a mouse model of manifesting Duchenne muscular dystrophy female carriers

Nouet, J., Himelman, E., Lahey, K. C., Zhao, Q. & Fraidenraich, D., Dec 1 2020, In : Scientific reports. 10, 1, 5683.

Rutgers, The State University

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

HIF1α Regulates Early Metabolic Changes due to Activation of Innate Immunity in Nuclear Reprogramming

Liu, C., Ruan, H., Himmati, F., Zhao, M. T., Chen, C. C., Makar, M., Chen, I. Y., Sallam, K., Mocarski, E. S., Sayed, D. & Sayed, N., Feb 11 2020, In : Stem Cell Reports. 14, 2, p. 192-200 9 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Host genotype and exercise exhibit species-level selection for members of the gut bacterial communities in the mouse digestive system

Dowden, R. A., McGuinness, L. R., Wisniewski, P. J., Campbell, S. C., Guers, J. J., Oydanich, M., Vatner, S. F., Häggblom, M. M. & Kerkhof, L. J., Dec 1 2020, In : Scientific reports. 10, 1, 8984.

Rutgers, The State University

Research output: Contribution to journalArticle

Open Access

Interaction between the autophagy protein Beclin 1 and Na+,K+-ATPase during starvation, exercise, and ischemia

Fernández, Á. F., Liu, Y., Ginet, V., Shi, M., Nah, J., Zou, Z., Zhou, A., Posner, B. A., Xiao, G., Tanguy, M., Paradis, V., Sadoshima, J., Rautou, P. E., Puyal, J., Hu, M. C. & Levine, B., Jan 16 2020, In : JCI Insight. 5, 1, e133282.

Rutgers, The State University

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Iron overload, oxidative stress and calcium mishandling in cardiomyocytes: Role of the mitochondrial permeability transition pore

Gordan, R., Fefelova, N., Gwathmey, J. K. & Xie, L. H., Aug 2020, In : Antioxidants. 9, 8, p. 1-15 15 p., 758.

Rutgers, The State University

Research output: Contribution to journalArticle

Open Access

Mechanisms of increased vascular stiffness down the aortic tree in aging, premenopausal female monkeys

Babici, D., Kudej, R. K., McNulty, T., Zhang, J., Oydanich, M., Berkman, T., Nishimura, K., Bishop, S. P., Vatner, D. E. & Vatner, S. F., Jul 2020, In : American Journal of Physiology - Heart and Circulatory Physiology. 319, 1, p. H222-H234

Rutgers, The State University

Research output: Contribution to journalArticle

Multiple Levels of PGC-1α Dysregulation in Heart Failure

Oka, S. I., Sabry, A. D., Cawley, K. M. & Warren, J. S., Jan 30 2020, In : Frontiers in Cardiovascular Medicine. 7, 2.

Rutgers, The State University

Research output: Contribution to journalReview article

Open Access
2 Scopus citations

Perm1 regulates cardiac energetics as a downstream target of the histone methyltransferase Smyd1

Oka, S. I., Sabry, A. D., Horiuchi, A. K., Cawley, K. M., O'Very, S. A., Zaitsev, M. A., Shankar, T. S., Byun, J., Mukai, R., Xu, X., Torres, N. S., Kumar, A., Yazawa, M., Ling, J., Taleb, I., Saijoh, Y., Drakos, S. G., Sadoshima, J. & Warren, J. S., Jun 2020, In : PLoS ONE. 15, 6, e0234913.

Rutgers, The State University

Research output: Contribution to journalArticle

Open Access
Open Access
Open Access
1 Scopus citations

Single SERCA2a Therapy Ameliorated Dilated Cardiomyopathy for 18 Months in a Mouse Model of Duchenne Muscular Dystrophy

Wasala, N. B., Yue, Y., Lostal, W., Wasala, L. P., Niranjan, N., Hajjar, R. J., Babu, G. J. & Duan, D., Mar 4 2020, In : Molecular Therapy. 28, 3, p. 845-854 10 p.

Rutgers, The State University

Research output: Contribution to journalArticle

1 Scopus citations

Sirt1–nox4 signaling axis regulates cancer cachexia

Dasgupta, A., Shukla, S. K., Vernucci, E., King, R. J., Abrego, J., Mulder, S. E., Mullen, N. J., Graves, G., Buettner, K., Thakur, R., Murthy, D., Attri, K. S., Wang, D., Chaika, N. V., Pacheco, C. G., Rai, I., Engle, D. D., Grandgenett, P. M., Punsoni, M., Reames, B. N. & 10 others, Teoh-Fitzgerald, M., Oberley-Deegan, R., Yu, F., Klute, K. A., Hollingsworth, M. A., Zimmerman, M. C., Mehla, K., Sadoshima, J., Tuveson, D. A. & Singh, P. K., Jul 6 2020, In : Journal of Experimental Medicine. 217, 7, e20190745.

Rutgers, The State University

Research output: Contribution to journalArticle

1 Scopus citations

The role of Drp1 in mitophagy and cell death in the heart

Tong, M., Zablocki, D. & Sadoshima, J., May 2020, In : Journal of Molecular and Cellular Cardiology. 142, p. 138-145 8 p.

Rutgers, The State University

Research output: Contribution to journalArticle

5 Scopus citations

Thioredoxin-1maintainsmitochondrial function viamechanistic target of rapamycin signalling in the heart

Oka, S. I., Chin, A., Park, J. Y., Ikeda, S., Mizushima, W., Ralda, G., Zhai, P., Tong, M., Byun, J., Tang, F., Einaga, Y., Huang, C. Y., Kashihara, T., Zhao, M., Nah, J., Tian, B., Hirabayashi, Y., Yodoi, J. & Sadoshima, J., Aug 1 2020, In : Cardiovascular research. 116, 10, p. 1742-1755 14 p.

Rutgers, The State University

Research output: Contribution to journalArticle

3 Scopus citations

Upregulation of Rubicon promotes autosis during myocardial ischemia/reperfusion injury

Nah, J., Zhai, P., Huang, C. Y., Fernández, Á. F., Mareedu, S., Levine, B. & Sadoshima, J., Jun 1 2020, In : Journal of Clinical Investigation. 130, 6, p. 2978-2991 14 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB

Chen, G., Xie, W., Nah, J., Sauvat, A., Liu, P., Pietrocola, F., Sica, V., Carmona-Gutierrez, D., Zimmermann, A., Pendl, T., Tadic, J., Bergmann, M., Hofer, S. J., Domuz, L., Lachkar, S., Markaki, M., Tavernarakis, N., Sadoshima, J., Madeo, F., Kepp, O. & 1 others, Kroemer, G., Nov 7 2019, In : EMBO Molecular Medicine. 11, 11, e10469.

Rutgers, The State University

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia

Saito, T., Nah, J., Oka, S. I., Mukai, R., Monden, Y., Maejima, Y., Ikeda, Y., Sciarretta, S., Liu, T., Li, H., Baljinnyam, E., Fraidenraich, D., Fritzky, L., Zhai, P., Ichinose, S., Isobe, M., Hsu, C. P., Kundu, M. & Sadoshima, J., Feb 1 2019, In : Journal of Clinical Investigation. 129, 2, p. 802-819 18 p.

Rutgers, The State University

Research output: Contribution to journalArticle

43 Scopus citations

A Spatiotemporal Ventricular Myocyte Model Incorporating Mitochondrial Calcium Cycling

Song, Z., Xie, L. H., Weiss, J. N. & Qu, Z., Dec 17 2019, In : Biophysical journal. 117, 12, p. 2349-2360 12 p.

Rutgers, The State University

Research output: Contribution to journalArticle

2 Scopus citations

Both gain and loss of Nampt function promote pressure overload-induced heart failure

Byun, J., Oka, S. I., Imai, N., Huang, C. Y., Ralda, G., Zhai, P., Ikeda, Y., Ikeda, S. & Sadoshima, J., 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 317, 4, p. H711-H725

Rutgers, The State University

Research output: Contribution to journalArticle

3 Scopus citations

Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration

Abdullah, C. S., Alam, S., Aishwarya, R., Miriyala, S., Bhuiyan, M. A. N., Panchatcharam, M., Pattillo, C. B., Orr, A. W., Sadoshima, J., Hill, J. A. & Bhuiyan, M. S., Dec 1 2019, In : Scientific reports. 9, 1, 2002.

Rutgers, The State University

Research output: Contribution to journalArticle

18 Scopus citations

Dual PPARα/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction

Kalliora, C., Kyriazis, I. D., Oka, S. I., Lieu, M. J., Yue, Y., Area-Gomez, E., Pol, C. J., Tian, Y., Mizushima, W., Chin, A., Scerbo, D., Schulze, P. C., Civelek, M., Sadoshima, J., Madesh, M., Goldberg, I. J. & Drosatos, K., Sep 5 2019, In : JCI Insight. 4, 17, e129556.

Rutgers, The State University

Research output: Contribution to journalArticle

6 Scopus citations

Endogenous muscle atrophy F-box is involved in the development of cardiac rupture after myocardial infarction

Usui, S., Chikata, A., Takatori, O., Takashima, S. I., Inoue, O., Kato, T., Murai, H., Furusho, H., Nomura, A., Zablocki, D., Kaneko, S., Sadoshima, J. & Takamura, M., Jan 2019, In : Journal of Molecular and Cellular Cardiology. 126, p. 1-12 12 p.

Rutgers, The State University

Research output: Contribution to journalArticle

2 Scopus citations

Fundamental mechanisms of regulated cell death and implications for heart disease

Del Re, D. P., Amgalan, D., Linkermann, A., Liu, Q. & Kitsis, R. N., Jul 2019, In : Physiological reviews. 99, 4, p. 1765-1817 53 p.

Rutgers, The State University

Research output: Contribution to journalArticle

37 Scopus citations

Galectin-3 deficiency ameliorates fibrosis and remodeling in dilated cardiomyopathy mice with enhanced mst1 signaling

Nguyen, M. N., Ziemann, M., Kiriazis, H., Su, Y., Thomas, Z., Lu, Q., Donner, D. G., Zhao, W. B., Rafehi, H., Sadoshima, J., McMullen, J. R., El-Osta, A. & Du, X. J., Jan 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 316, 1, p. H45-H60

Rutgers, The State University

Research output: Contribution to journalArticle

12 Scopus citations

Glucocorticoid Receptor-Binding and Transcriptome Signature in Cardiomyocytes

Severinova, E., Alikunju, S., Deng, W., Dhawan, P., Sayed, N. & Sayed, D., Mar 19 2019, In : Journal of the American Heart Association. 8, 6, e011484.

Rutgers, The State University

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Glycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy

Nakamura, M., Liu, T., Husain, S., Zhai, P., Warren, J. S., Hsu, C. P., Matsuda, T., Phiel, C. J., Cox, J. E., Tian, B., Li, H. & Sadoshima, J., May 7 2019, In : Cell Metabolism. 29, 5, p. 1119-1134.e12

Rutgers, The State University

Research output: Contribution to journalArticle

7 Scopus citations

Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation during Pressure Overload

Ikeda, S., Mizushima, W., Sciarretta, S., Abdellatif, M., Zhai, P., Mukai, R., Fefelova, N., Oka, S. I., Nakamura, M., Del Re, D. P., Farrance, I., Park, J. Y., Tian, B., Xie, L. H., Kumar, M., Hsu, C. P., Sadayappan, S., Shimokawa, H., Lim, D. S. & Sadoshima, J., Jan 18 2019, In : Circulation research. 124, 2, p. 292-305 14 p.

Rutgers, The State University

Research output: Contribution to journalArticle

15 Scopus citations

Hsp22 overexpression induces myocardial hypertrophy, senescence and reduced life span through enhanced oxidative stress

Morin, D., Long, R., Panel, M., Laure, L., Taranu, A., Gueguen, C., Pons, S., Leoni, V., Caccia, C., Vatner, S. F., Vatner, D. E., Qiu, H., Depre, C., Berdeaux, A. & Ghaleh, B., Jun 2019, In : Free Radical Biology and Medicine. 137, p. 194-200 7 p.

Rutgers, The State University

Research output: Contribution to journalArticle

2 Scopus citations

Intermittent fasting reverses an advanced form of cardiomyopathy

Mukai, R., Zablocki, D. & Sadoshima, J., 2019, In : Journal of the American Heart Association. 8, 4, e011863.

Rutgers, The State University

Research output: Contribution to journalEditorial

Open Access
1 Scopus citations

Ketone body can be a fuel substrate for failing heart

Nakamura, M. & Sadoshima, J., Sep 1 2019, In : Cardiovascular research. 115, 11, p. 1567-1569 3 p.

Rutgers, The State University

Research output: Contribution to journalEditorial

Open Access
3 Scopus citations

Mechanisms of sex differences in exercise capacity

Oydanich, M., Babici, D., Zhang, J., Rynecki, N., Vatner, D. E. & Vatner, S. F., 2019, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 316, 6, p. R832-R838

Rutgers, The State University

Research output: Contribution to journalArticle

7 Scopus citations

Mitochondrial LonP1 protects cardiomyocytes from ischemia/reperfusion injury in vivo

Venkatesh, S., Li, M., Saito, T., Tong, M., Rashed, E., Mareedu, S., Zhai, P., Bárcena, C., López-Otín, C., Yehia, G., Sadoshima, J. & Suzuki, C. K., Mar 2019, In : Journal of Molecular and Cellular Cardiology. 128, p. 38-50 13 p.

Rutgers, The State University

Research output: Contribution to journalArticle

14 Scopus citations

Mitophagy Is Essential for Maintaining Cardiac Function during High Fat Diet-Induced Diabetic Cardiomyopathy

Tong, M., Saito, T., Zhai, P., Oka, S. I., Mizushima, W., Nakamura, M., Ikeda, S., Shirakabe, A. & Sadoshima, J., Apr 26 2019, In : Circulation research. 124, 9, p. 1360-1371 12 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Open Access
40 Scopus citations

Nuclear miR-320 Controls Lipotoxicity

Tong, M. & Sadoshima, J., Dec 6 2019, In : Circulation research. 125, 12, p. 1121-1123 3 p.

Rutgers, The State University

Research output: Contribution to journalReview article

2 Scopus citations

Recruitment of RNA Polymerase II to Metabolic Gene Promoters Is Inhibited in the Failing Heart Possibly Through PGC-1α (Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α) Dysregulation

Bhat, S., Chin, A., Shirakabe, A., Ikeda, Y., Ikeda, S., Zhai, P., Hsu, C. P., Sayed, D., Abdellatif, M., Byun, J., Schesing, K., Tang, F., Tian, Y., Babu, G., Ralda, G., Warren, J. S., Cho, J., Sadoshima, J. & Oka, S. I., Mar 1 2019, In : Circulation: Heart Failure. 12, 3, e005529.

Rutgers, The State University

Research output: Contribution to journalArticle

3 Scopus citations

Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca2+-ATPase in Heart Failure

Gorski, P. A., Jang, S. P., Jeong, D., Lee, A., Lee, P., Oh, J. G., Chepurko, V., Yang, D. K., Kwak, T. H., Eom, S. H., Park, Z. Y., Yoo, Y. J., Kim, D. H., Kook, H., Sunagawa, Y., Morimoto, T., Hasegawa, K., Sadoshima, J., Vangheluwe, P., Hajjar, R. J. & 2 others, Park, W. J. & Kho, C., Apr 26 2019, In : Circulation research. 124, 9, p. e63-e80

Rutgers, The State University

Research output: Contribution to journalArticle

12 Scopus citations

Role of YAP/TAZ in Energy Metabolism in the Heart

Kashihara, T. & Sadoshima, J., 2019, In : Journal of cardiovascular pharmacology. 74, 6, p. 483-490 8 p.

Rutgers, The State University

Research output: Contribution to journalReview article

1 Scopus citations

Sarcolipin overexpression impairs myogenic differentiation in Duchenne muscular dystrophy

Niranjan, N., Mareedu, S., Tian, Y., Kodippili, K., Fefelova, N., Voit, A., Xie, L. H., Duan, D. & Babu, G. J., 2019, In : American Journal of Physiology - Cell Physiology. 317, 4, p. C813-C824

Rutgers, The State University

Research output: Contribution to journalArticle

1 Scopus citations

Scientists on the Spot: Autophagy and heart disease

Voigt, N. & Sadoshima, J., Jan 1 2019, In : Cardiovascular research. 115, 10, p. E91-E92

Rutgers, The State University

Research output: Contribution to journalReview article

Open Access
Open Access
4 Scopus citations

Stimulation of β-adrenoceptors up-regulates cardiac expression of galectin-3 and BIM through the Hippo signalling pathway

Zhao, W. B., Lu, Q., Nguyen, M. N., Su, Y., Ziemann, M., Wang, L. N., Kiriazis, H., Puthalakath, H., Sadoshima, J., Hu, H. Y. & Du, X. J., Jul 2019, In : British Journal of Pharmacology. 176, 14, p. 2465-2481 17 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
Open Access
2 Scopus citations

The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species

Carmona-Gutierrez, D., Zimmermann, A., Kainz, K., Pietrocola, F., Chen, G., Maglioni, S., Schiavi, A., Nah, J., Mertel, S., Beuschel, C. B., Castoldi, F., Sica, V., Trausinger, G., Raml, R., Sommer, C., Schroeder, S., Hofer, S. J., Bauer, M. A., Pendl, T., Tadic, J. & 21 others, Dammbrueck, C., Hu, Z., Ruckenstuhl, C., Eisenberg, T., Durand, S., Bossut, N., Aprahamian, F., Abdellatif, M., Sedej, S., Enot, D. P., Wolinski, H., Dengjel, J., Kepp, O., Magnes, C., Sinner, F., Pieber, T. R., Sadoshima, J., Ventura, N., Sigrist, S. J., Kroemer, G. & Madeo, F., Dec 1 2019, In : Nature communications. 10, 1, 651.

Rutgers, The State University

Research output: Contribution to journalArticle

Open Access
29 Scopus citations