Princeton Branch of the Ludwig Institute for Cancer Research

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74139 Citations
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2025

A meta-analysis of the gut microbiome in inflammatory bowel disease patients identifies disease-associated small molecules
Elmassry, M. M., Sugihara, K., Chankhamjon, P., Kim, Y., Camacho, F. R., Wang, S., Sugimoto, Y., Chatterjee, S., Chen, L. A., Kamada, N. & Donia, M. S., Feb 12 2025, In: Cell Host and Microbe. 33, 2, p. 218-234.e12
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Aminoalkylation of Alkenes Enabled by Triple Radical Sorting
Lyon, W. L., Wang, J. Z., Alcázar, J. & MacMillan, D. W. C., Jan 22 2025, In: Journal of the American Chemical Society. 147, 3, p. 2296-2302 7 p.
Princeton University
Research output: Contribution to journal › Article › peer-review
Bacterial species with different nanocolony morphologies have distinct flow-dependent colonization behaviors
Hallinen, K. M., Bodine, S. P., Stone, H. A., Muir, T. W., Wingreen, N. S. & Gitai, Z., Feb 19 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 7, e2419899122.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Characterizing the evolution of defense in a tripartite marine symbiosis using adaptive dynamics
Singh, P., Bruijning, M., Carver, G. D., Donia, M. S. & Metcalf, C. J. E., Feb 1 2025, In: Evolution Letters. 9, 1, p. 105-114 10 p.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Macromolecular interactions and geometrical confinement determine the 3D diffusion of ribosome-sized particles in live Escherichia coli cells
Valverde-Mendez, D., Sunol, A. M., Bratton, B. P., Delarue, M., Hofmann, J. L., Sheehan, J. P., Gitai, Z., Holt, L. J., Shaevitz, J. W. & Zia, R. N., Jan 28 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 4, e2406340121.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Terminal differentiation and persistence of effector regulatory T cells essential for preventing intestinal inflammation
Dikiy, S., Ghelani, A. P., Levine, A. G., Martis, S., Giovanelli, P., Wang, Z. M., Beroshvili, G., Pritykin, Y., Krishna, C., Huang, X., Glasner, A., Greenbaum, B. D., Leslie, C. S. & Rudensky, A. Y., 2025, (Accepted/In press) In: Nature Immunology. e40553.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
2024
A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting
Chain, C., Sheehan, J. P., Xu, X., Ghaffari, S., Godbole, A., Kim, H., Freundlich, J. S., Rabinowitz, J. D. & Gitai, Z., May 2024, In: Nature Microbiology. 9, 5, p. 1207-1219 13 p.
Princeton University, Rutgers, The State University
Research output: Contribution to journal › Article › peer-review

Open Access
Alcohol-alcohol cross-coupling enabled by S_H2 radical sorting
Chen, R., Intermaggio, N. E., Xie, J., Rossi-Ashton, J. A., Gould, C. A., Martin, R. T., Alcázar, J. & MacMillan, D. W. C., Mar 22 2024, In: Science. 383, 6689, p. 1350-1357 8 p.
Princeton University
Research output: Contribution to journal › Article › peer-review
Alkene dialkylation by triple radical sorting
Wang, J. Z., Lyon, W. L. & MacMillan, D. W. C., Apr 4 2024, In: Nature. 628, 8006, p. 104-109 6 p.
Princeton University
Research output: Contribution to journal › Article › peer-review
A natural bacterial pathogen of C. elegans uses a small RNA to induce transgenerational inheritance of learned avoidance
Sengupta, T., Ange, J. S., Kaletsky, R., Moore, R. S., Seto, R. J., Marogi, J., Myhrvold, C., Gitai, Z. & Murphy, C. T., Mar 28 2024, In: PLoS genetics. 20, 3, e1011178.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Bioelectric stimulation controls tissue shape and size
Shim, G., Breinyn, I. B., Martínez-Calvo, A., Rao, S. & Cohen, D. J., Dec 2024, In: Nature communications. 15, 1, 2938.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Biophysics of morphogenesis in the vertebrate lung
Banavar, S. P., Fowler, E. W. & Nelson, C. M., Jan 2024, In: Current topics in developmental biology. 160, p. 65-86 22 p.
Princeton University
Research output: Contribution to journal › Article › peer-review
Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance
Lee, H., Horbath, A., Kondiparthi, L., Meena, J. K., Lei, G., Dasgupta, S., Liu, X., Zhuang, L., Koppula, P., Li, M., Mahmud, I., Wei, B., Lorenzi, P. L., Keyomarsi, K., Poyurovsky, M. V., Olszewski, K. & Gan, B., Dec 2024, In: Nature communications. 15, 1, 79.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defence in KRAS-mutant lung cancer
Lee, H. M., Muhammad, N., Lieu, E. L., Cai, F., Mu, J., Ha, Y. S., Cao, G., Suchors, C., Joves, K., Chronis, C., Li, K., Ducker, G. S., Olszewski, K., Cai, L., Allison, D. B., Bachert, S. E., Ewing, W. R., Wong, H., Seo, H. & Kim, I. Y. & 3 others, Faubert, B., Kim, J. & Kim, J., Jul 2024, In: Nature Metabolism. 6, 7, p. 1310-1328 19 p.
Princeton University
Research output: Contribution to journal › Article › peer-review
Couple-close construction of polycyclic rings from diradicals
Long, A., Oswood, C. J., Kelly, C. B., Bryan, M. C. & MacMillan, D. W. C., Apr 11 2024, In: Nature. 628, 8007, p. 326-332 7 p.
Princeton University
Research output: Contribution to journal › Article › peer-review
Development of a dual channel detection system for pan-genotypic simultaneous quantification of hepatitis B and delta viruses
Liu, Y., Maya, S., Carver, S., O’Connell, A. K., Tseng, A. E., Gertje, H. P., Seneca, K., Nahass, R. G., Crossland, N. A. & Ploss, A., 2024, In: Emerging Microbes and Infections. 13, 1, 2350167.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Development of a General Organophosphorus Radical Trap: Deoxyphosphonylation of Alcohols
Bissonnette, N. B., Bisballe, N., Tran, A. V., Rossi-Ashton, J. A. & MacMillan, D. W. C., Mar 27 2024, In: Journal of the American Chemical Society. 146, 12, p. 7942-7949 8 p.
Princeton University
Research output: Contribution to journal › Article › peer-review
Direct Bioisostere Replacement Enabled by Metallaphotoredox Deoxydifluoromethylation
Mao, E., Prieto Kullmer, C. N., Sakai, H. A. & MacMillan, D. W. C., Feb 28 2024, In: Journal of the American Chemical Society. 146, 8, p. 5067-5073 7 p.
Princeton University
Research output: Contribution to journal › Article › peer-review
E-cadherin biomaterials reprogram collective cell migration and cell cycling by forcing homeostatic conditions
Suh, K., Cho, Y. K., Breinyn, I. B. & Cohen, D. J., Feb 27 2024, In: Cell Reports. 43, 2, 113743.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Emx2 underlies the development and evolution of marsupial gliding membranes
Moreno, J. A., Dudchenko, O., Feigin, C. Y., Mereby, S. A., Chen, Z., Ramos, R., Almet, A. A., Sen, H., Brack, B. J., Johnson, M. R., Li, S., Wang, W., Gaska, J. M., Ploss, A., Weisz, D., Omer, A. D., Yao, W., Colaric, Z., Kaur, P. & Leger, J. S. & 10 others, Nie, Q., Mena, A., Flanagan, J. P., Keller, G., Sanger, T., Ostrow, B., Plikus, M. V., Kvon, E. Z., Aiden, E. L. & Mallarino, R., May 2 2024, In: Nature. 629, 8010, p. 127-135 9 p.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Engaging Alkenes in Metallaphotoredox: A Triple Catalytic, Radical Sorting Approach to Olefin-Alcohol Cross-Coupling
Cai, Q., McWhinnie, I. M., Dow, N. W., Chan, A. Y. & MacMillan, D. W. C., May 8 2024, In: Journal of the American Chemical Society. 146, 18, p. 12300-12309 10 p.
Princeton University
Research output: Contribution to journal › Article › peer-review
Ensemble Detection of DNA Engineering Signatures
Adler, A., Bader, J. S., Basnight, B., Booth, B. W., Cai, J., Cho, E., Collins, J. H., Ge, Y., Grothendieck, J., Keating, K., Marshall, T., Persikov, A., Scott, H., Siegelmann, R., Singh, M., Taggart, A., Toll, B., Wan, K. H., Wyschogrod, D. & Yaman, F. & 3 others, Young, E. M., Celniker, S. E. & Roehner, N., Apr 19 2024, In: ACS Synthetic Biology. 13, 4, p. 1105-1115 11 p.
Princeton University
Research output: Contribution to journal › Article › peer-review
Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses
Hartmann, J. A., Cardoso, M. R., Talarico, M. C. R., Kenney, D. J., Leone, M. R., Reese, D. C., Turcinovic, J., O'Connell, A. K., Gertje, H. P., Marino, C., Ojeda, P. E., De Paula, E. V., Orsi, F. A., Velloso, L. A., Cafiero, T. R., Connor, J. H., Ploss, A., Hoelzemer, A., Carrington, M. & Barczak, A. K. & 4 others, Crossland, N. A., Douam, F., Boucau, J. & Garcia-Beltran, W. F., May 9 2024, In: Cell. 187, 10, p. 2393-2410.e14
Princeton University
Research output: Contribution to journal › Article › peer-review
Free-Radical Deoxygenative Amination of Alcohols via Copper Metallaphotoredox Catalysis
Carson, W. P., Tsymbal, A. V., Pipal, R. W., Edwards, G. A., Martinelli, J. R., Cabré, A. & MacMillan, D. W. C., Jun 12 2024, In: Journal of the American Chemical Society. 146, 23, p. 15681-15687 7 p.
Princeton University
Research output: Contribution to journal › Article › peer-review
Genetic determinants of host- and virus-derived insertions for hepatitis E virus replication
Wißing, M. H., Meister, T. L., Nocke, M. K., Gömer, A., Masovic, M., Knegendorf, L., Brüggemann, Y., Bader, V., Siddharta, A., Bock, C. T., Ploss, A., Kenney, S. P., Winklhofer, K. F., Behrendt, P., Wedemeyer, H., Steinmann, E. & Todt, D., Dec 2024, In: Nature communications. 15, 1, 4855.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Global protein turnover quantification in Escherichia coli reveals cytoplasmic recycling under nitrogen limitation
Gupta, M., Johnson, A. N. T., Costa, E. J., Guest, R. L., Li, S. H. J., Hart, E. M., Nguyen, T., Stadlmeier, M., Bratton, B. P., Silhavy, T. J., Wingreen, N. S., Gitai, Z. & Wühr, M., Dec 2024, In: Nature communications. 15, 1, 5890.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Glucose-6-phosphate dehydrogenase maintains redox homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung cancer
Lan, T., Arastu, S., Lam, J., Kim, H., Wang, W., Wang, S., Bhatt, V., Lopes, E. C., Hu, Z., Sun, M., Luo, X., Ghergurovich, J. M., Su, X., Rabinowitz, J. D., White, E. & Guo, J. Y., Dec 2024, In: Nature communications. 15, 1, 5857.
Rutgers, The State University, Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Glycine homeostasis requires reverse SHMT flux
McBride, M. J., Hunter, C. J., Zhang, Z., TeSlaa, T., Xu, X., Ducker, G. S. & Rabinowitz, J. D., Jan 2 2024, In: Cell Metabolism. 36, 1, p. 103-115.e4
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Heavy Metal Contamination in Birds from Protected Regions in the Amazon
Loera, Y., Gruppi, C., Swing, K., Campbell-Staton, S. C., Milá, B. & Smith, T. B., Dec 2024, In: Environmental Toxicology and Chemistry. 43, 12, p. 2601-2607 7 p.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
How important is EMT for cancer metastasis?
Celià-Terrassa, T. & Kang, Y., Feb 2024, In: PLoS Biology. 22, 2 February, e3002487.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Intracellular Delivery of Stabilized Peptide Blocking MTDH-SND1 Interaction for Breast Cancer Suppression
Chen, H., Zhan, M., Zhang, Y., Liu, J., Wang, R., An, Y., Gao, Z., Jiang, L., Xing, Y., Kang, Y., Li, Z. & Yin, F., Jan 22 2024, In: JACS Au. 4, 1, p. 139-149 11 p.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Mathematical Models of Early Hepatitis B Virus Dynamics in Humanized Mice
Ciupe, S. M., Dahari, H. & Ploss, A., May 2024, In: Bulletin of Mathematical Biology. 86, 5, 53.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex
Paramore, S. V., Goodwin, K., Fowler, E. W., Devenport, D. & Nelson, C. M., Aug 2024, In: Development (Cambridge). 151, 16, dev202692.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Mitochondrial ATP generation is more proteome efficient than glycolysis
Shen, Y., Dinh, H. V., Cruz, E. R., Chen, Z., Bartman, C. R., Xiao, T., Call, C. M., Ryseck, R. P., Pratas, J., Weilandt, D., Baron, H., Subramanian, A., Fatma, Z., Wu, Z. Y., Dwaraknath, S., Hendry, J. I., Tran, V. G., Yang, L., Yoshikuni, Y. & Zhao, H. & 3 others, Maranas, C. D., Wühr, M. & Rabinowitz, J. D., Sep 2024, In: Nature Chemical Biology. 20, 9, p. 1123-1132 10 p.
Princeton University
Research output: Contribution to journal › Article › peer-review
mTORC1 controls murine postprandial hepatic glycogen synthesis via Ppp1r3b
Uehara, K., Lee, W. D., Stefkovich, M., Biswas, D., Santoleri, D., Whitlock, A. G., Quinn, W., Coopersmith, T., Creasy, K. T., Rader, D. J., Sakamoto, K., Rabinowitz, J. D. & Titchenell, P. M., Apr 1 2024, In: Journal of Clinical Investigation. 134, 7, e173782.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Multicenter integrated analysis of noncoding CRISPRi screens
Yao, D., Tycko, J., Oh, J. W., Bounds, L. R., Gosai, S. J., Lataniotis, L., Mackay-Smith, A., Doughty, B. R., Gabdank, I., Schmidt, H., Guerrero-Altamirano, T., Siklenka, K., Guo, K., White, A. D., Youngworth, I., Andreeva, K., Ren, X., Barrera, A., Luo, Y. & Yardımcı, G. G. & 14 others, Tewhey, R., Kundaje, A., Greenleaf, W. J., Sabeti, P. C., Leslie, C., Pritykin, Y., Moore, J. E., Beer, M. A., Gersbach, C. A., Reddy, T. E., Shen, Y., Engreitz, J. M., Bassik, M. C. & Reilly, S. K., Apr 2024, In: Nature Methods. 21, 4, p. 723-734 12 p.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
One-carbon unit supplementation fuels purine synthesis in tumor-infiltrating T cells and augments checkpoint blockade
Xu, X., Chen, Z., Bartman, C. R., Xing, X., Olszewski, K. & Rabinowitz, J. D., May 16 2024, In: Cell Chemical Biology. 31, 5, p. 932-943.e8
Princeton University
Research output: Contribution to journal › Article › peer-review
Parallel Proteomic and Transcriptomic Microenvironment Mapping (μMap) of Nuclear Condensates in Living Cells
Knutson, S. D., Pan, C. R., Bisballe, N., Bloomer, B. J., Raftopolous, P., Saridakis, I. & MacMillan, D. W. C., 2024, (Accepted/In press) In: Journal of the American Chemical Society.
Princeton University
Research output: Contribution to journal › Article › peer-review
Parameter identifiability and model selection for partial differential equation models of cell invasion
Liu, Y., Suh, K., Maini, P. K., Cohen, D. J. & Baker, R. E., Mar 6 2024, In: Journal of the Royal Society Interface. 21, 212, 20230607.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Phenotypic plasticity – Implications for tumours in bone
Han, Y. & Kang, Y., Apr 2024, In: Journal of Bone Oncology. 45, 100592.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction
Amor, C., Fernández-Maestre, I., Chowdhury, S., Ho, Y. J., Nadella, S., Graham, C., Carrasco, S. E., Nnuji-John, E., Feucht, J., Hinterleitner, C., Barthet, V. J. A., Boyer, J. A., Mezzadra, R., Wereski, M. G., Tuveson, D. A., Levine, R. L., Jones, L. W., Sadelain, M. & Lowe, S. W., Mar 2024, In: Nature Aging. 4, 3, p. 336-349 14 p.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis
Liu, X., Chen, Z., Yan, Y., Zandkarimi, F., Nie, L., Li, Q., Horbath, A., Olszewski, K., Kondiparthi, L., Mao, C., Lee, H., Zhuang, L., Poyurovsky, M., Stockwell, B. R., Chen, J. & Gan, B., Sep 1 2024, In: Protein and Cell. 15, 9, p. 686-703 18 p.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Pseudomonas aeruginosa modulates both Caenorhabditis elegans attraction and pathogenesis by regulating nitrogen assimilation
Marogi, J. G., Murphy, C. T., Myhrvold, C. & Gitai, Z., Dec 2024, In: Nature communications. 15, 1, 7927.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Redefining the Synthetic Logic of Medicinal Chemistry. Photoredox-Catalyzed Reactions as a General Tool for Aliphatic Core Functionalization
Fernández, D. F., González-Esguevillas, M., Keess, S., Schäfer, F., Mohr, J., Shavnya, A., Knauber, T., Blakemore, D. C. & MacMillan, D. W. C., Apr 12 2024, In: Organic letters. 26, 14, p. 2702-2707 6 p.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Relatively Rare Populations of Invasive Cells Drive Progression of Heterogeneous Tumors
Leggett, S. E., Brennan, M. C., Martinez, S., Tien, J. & Nelson, C. M., Feb 2024, In: Cellular and Molecular Bioengineering. 17, 1, p. 7-24 18 p.
Princeton University
Research output: Contribution to journal › Article › peer-review
Removal of Pseudomonas type IV pili by a small RNA virus
Thongchol, J., Yu, Z., Harb, L., Lin, Y., Koch, M., Theodore, M., Narsaria, U., Shaevitz, J., Gitai, Z., Wu, Y., Zhang, J. & Zeng, L., Apr 5 2024, In: Science. 384, 6691, eadl0635.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Selected Ion Monitoring for Orbitrap-Based Metabolomics
Lu, W., McBride, M. J., Lee, W. D., Xing, X., Xu, X., Li, X., Oschmann, A. M., Shen, Y., Bartman, C. & Rabinowitz, J. D., Apr 2024, In: Metabolites. 14, 4, 184.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
Single-cell multi-ome regression models identify functional and disease-associated enhancers and enable chromatin potential analysis
Mitra, S., Malik, R., Wong, W., Rahman, A., Hartemink, A. J., Pritykin, Y., Dey, K. K. & Leslie, C. S., Apr 2024, In: Nature genetics. 56, 4, p. 627-636 10 p.
Princeton University
Research output: Contribution to journal › Article › peer-review

Open Access
TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models
Wilson, E. N., Wang, C., Swarovski, M. S., Zera, K. A., Ennerfelt, H. E., Wang, Q., Chaney, A., Gauba, E., Ramos Benitez, J. A., Le Guen, Y., Minhas, P. S., Panchal, M., Tan, Y. J., Blacher, E., A. Iweka, C., Cropper, H., Jain, P., Liu, Q., Mehta, S. S. & Zuckerman, A. J. & 12 others, Xin, M., Umans, J., Huang, J., Durairaj, A. S., Serrano, G. E., Beach, T. G., Greicius, M. D., James, M. L., Buckwalter, M. S., McReynolds, M. R., Rabinowitz, J. D. & Andreasson, K. I., May 2024, In: Nature neuroscience. 27, 5, p. 873-885 13 p.
Princeton University
Research output: Contribution to journal › Article › peer-review
Triple Radical Sorting: Aryl-Alkylation of Alkenes
Wang, J. Z., Mao, E., Nguyen, J. A., Lyon, W. L. & MacMillan, D. W. C., Jun 12 2024, In: Journal of the American Chemical Society. 146, 23, p. 15693-15700 8 p.
Princeton University
Research output: Contribution to journal › Article › peer-review