Research output per year
Research output per year
Research output
- 1 - 50 out of 153 results
Search results
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2023
Apoptosis, autophagy, and cancer: the critical role Genes & Development played in paradigm shifts
White, E., Jan 1 2023, In: Genes and Development. 37, 1-2, p. 59-62 4 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Autophagy in PDGFRA+ mesenchymal cells is required for intestinal homeostasis and mammalian survival
Yang, Y. & White, E., 2023, In: Autophagy. 19, 2, p. 726-728 3 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Decreased autophagosome biogenesis, reduced NRF2, and enhanced ferroptotic cell death are underlying molecular mechanisms of non-alcoholic fatty liver disease
Liu, P., Anandhan, A., Chen, J., Shakya, A., Dodson, M., Ooi, A., Chapman, E., White, E., Garcia, J. G. & Zhang, D. D., Feb 2023, In: Redox Biology. 59, 102570.Research output: Contribution to journal › Article › peer-review
Open Access -
Discovery and Targeting of a Noncanonical Mechanism of Sarcoma Resistance to ADI-PEG20 Mediated by the Microenvironment
Rogers, L. C., Kremer, J. C., Brashears, C. B., Lin, Z., Hu, Z., Bastos, A. C. S., Baker, A., Fettig, N., Zhou, D., Shoghi, K. I., Dehner, C. A., Chrisinger, J. S. A., Bomalaski, J. S., Garcia, B. A., Oyama, T., White, E. P. & Van Tine, B. A., Aug 15 2023, In: Clinical Cancer Research. 29, 16, p. 3189-3202 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Inhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors
Bhatt, V., Lan, T., Wang, W., Kong, J., Lopes, E. C., Wang, J., Khayati, K., Raju, A., Rangel, M., Lopez, E., Hu, Z. S., Luo, X., Su, X., Malhotra, J., Hu, W., White, E. & Guo, J. Y., Jan 2023, In: Cell Death and Disease. 14, 1, 61.Research output: Contribution to journal › Article › peer-review
Open Access -
Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia
Ferrer, M., Mourikis, N., Davidson, E. E., Kleeman, S. O., Zaccaria, M., Habel, J., Rubino, R., Gao, Q., Flint, T. R., Young, L., Connell, C. M., Lukey, M. J., Goncalves, M. D., White, E. P., Venkitaraman, A. R. & Janowitz, T., Jul 11 2023, In: Cell Metabolism. 35, 7, p. 1147-1162.e7Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Autophagy in PDGFRα+ mesenchymal cells is essential for intestinal stem cell survival
Yang, Y., Marsh, T., Poillet-Perez, L., Sawant, A., Chen, L., Park, N. R., RaElle Jackson, S., Hu, Z., Alon, N., Liu, C., Debnath, J., Guan, J. L., Davidson, S., Verzi, M. & White, E., May 24 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 21, e2202016119.Research output: Contribution to journal › Article › peer-review
Open Access -
Transient Systemic Autophagy Inhibition Is Selectively and Irreversibly Deleterious to Lung Cancer
Khayati, K., Bhatt, V., Lan, T., Alogaili, F., Wang, W., Lopez, E., Hu, Z. S., Gokhale, S., Cassidy, L., Narita, M., Xie, P., White, E. & Guo, J. Y., Dec 1 2022, In: Cancer Research. 82, 23, p. 4429-4443 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Tumor suppressor PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7/autophagy to suppress neurodegeneration
Huo, Y., Sawant, A., Tan, Y., Mahdi, A. H., Li, T., Ma, H., Bhatt, V., Yan, R., Coleman, J., Dreyfus, C. F., Guo, J. Y., Maral Mouradian, M., White, E. & Xia, B., Apr 11 2022, In: PLoS genetics. 18, 4, e1010138.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
MDVs to the rescue: How autophagy-deficient cancer cells adapt to defective mitophagy
Poillet-Perez, L. & White, E., Jul 26 2021, In: Developmental cell. 56, 14, p. 2010-2012 3 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Mitochondrial Fission Factor Is a Novel Interacting Protein of the Critical B Cell Survival Regulator TRAF3 in B Lymphocytes
Liu, Y., Gokhale, S., Jung, J., Zhu, S., Luo, C., Saha, D., Guo, J. Y., Zhang, H., Kyin, S., Zong, W. X., White, E. & Xie, P., Oct 20 2021, In: Frontiers in immunology. 12, 670338.Research output: Contribution to journal › Article › peer-review
Open Access -
Non-canonical NRF2 activation promotes a pro-diabetic shift in hepatic glucose metabolism
Liu, P., Dodson, M., Li, H., Schmidlin, C. J., Shakya, A., Wei, Y., Garcia, J. G. N., Chapman, E., Kiela, P. R., Zhang, Q. Y., White, E., Ding, X., Ooi, A. & Zhang, D. D., Sep 2021, In: Molecular Metabolism. 51, 101243.Research output: Contribution to journal › Article › peer-review
Open Access -
SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer
Wang, X., Zhang, H., Sapio, R., Yang, J., Wong, J., Zhang, X., Guo, J. Y., Van Remmen, H., Li, H., White, E., Liu, C., Kiledjian, M., Pestov, D. G., Steven Zheng, X. F. & Pine, S., Dec 1 2021, In: Nature communications. 12, 1, 2259.Rutgers, The State University, Rowan University
Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response
Poillet-Perez, L., Sharp, D. W., Yang, Y., Laddha, S. V., Ibrahim, M., Bommareddy, P. K., Hu, Z. S., Vieth, J., Haas, M., Bosenberg, M. W., Rabinowitz, J. D., Cao, J., Guan, J. L., Ganesan, S., Chan, C. S., Mehnert, J. M., Lattime, E. C. & White, E., Sep 1 2020, In: Nature Cancer. 1, 9, p. 923-934 12 p.Princeton University, Rutgers, The State University
Research output: Contribution to journal › Article › peer-review
Open Access -
Autophagy promotes mammalian survival by suppressing oxidative stress and p53
Yang, Y., Karsli-Uzunbas, G., Poillet-Perez, L., Sawant, A., Hu, Z. S., Zhao, Y., Moore, D., Hu, W. & White, E., May 1 2020, In: Genes and Development. 34, 9-10, p. 688-700 13 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Autophagy suppresses TRP53/p53 and oxidative stress to enable mammalian survival
Yang, Y. & White, E., Jul 2 2020, In: Autophagy. 16, 7, p. 1355-1357 3 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Glucose-6-phosphate dehydrogenase is not essential for K-ras-driven tumor growth or metastasis
Ghergurovich, J. M., Esposito, M., Chen, Z., Wang, J. Z., Bhatt, V., Lan, T., White, E., Kang, Y., Guo, J. Y. & Rabinowitz, J. D., Sep 15 2020, In: Cancer Research. 80, 18, p. 3820-3829 10 p.Rutgers, The State University, Princeton University
Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression
Liu, J., Zhang, C., Wu, H., Sun, X. X., Li, Y., Huang, S., Yue, X., Lu, S. E., Shen, Z., Su, X., White, E., Haffty, B. G., Hu, W. & Feng, Z., Jun 1 2020, In: Journal of Clinical Investigation. 130, 6, p. 3253-3269 17 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Serine Catabolism Feeds NADH when Respiration Is Impaired
Yang, L., Garcia Canaveras, J. C., Chen, Z., Wang, L., Liang, L., Jang, C., Mayr, J. A., Zhang, Z., Ghergurovich, J. M., Zhan, L., Joshi, S., Hu, Z., McReynolds, M. R., Su, X., White, E., Morscher, R. J. & Rabinowitz, J. D., Apr 7 2020, In: Cell Metabolism. 31, 4, p. 809-821.e6Rutgers, The State University, Princeton University
Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
2019
A phase I trial of MK-2206 and hydroxychloroquine in patients with advanced solid tumors
Mehnert, J., Kaveney, A. D., Malhotra, J., Spencer, K., Portal, D., Tan, A. R., Moss, R. A., Lin, H., Bertino, J., Gibbon, D., Doyle, L. A., White, E. P. & Stein, M., Oct 1 2019, In: Cancer chemotherapy and pharmacology. 84, 4, p. 899-907 9 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells
Wang, Y., Xiong, H., Liu, D., Hill, C., Ertay, A., Li, J., Zou, Y., Miller, P., White, E., Downward, J., Goldin, R. D., Yuan, X. & Lu, X., May 4 2019, In: Autophagy. 15, 5, p. 886-899 14 p.Research output: Contribution to journal › Article › peer-review
Open Access30 Scopus citations -
Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism
Bott, A. J., Shen, J., Tonelli, C., Zhan, L., Sivaram, N., Jiang, Y. P., Yu, X., Bhatt, V., Chiles, E., Zhong, H., Maimouni, S., Dai, W., Velasquez, S., Pan, J. A., Muthalagu, N., Morton, J., Anthony, T. G., Feng, H., Lamers, W. H. & Murphy, D. J. & 9 others, , Oct 29 2019, In: Cell Reports. 29, 5, p. 1287-1298.e6Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids
Neinast, M. D., Jang, C., Hui, S., Murashige, D. S., Chu, Q., Morscher, R. J., Li, X., Zhan, L., White, E., Anthony, T. G., Rabinowitz, J. D. & Arany, Z., Feb 5 2019, In: Cell Metabolism. 29, 2, p. 417-429.e4Rutgers, The State University, Princeton University
Research output: Contribution to journal › Article › peer-review
Open Access98 Scopus citations -
2018
Autophagy maintains tumour growth through circulating arginine
Poillet-Perez, L., Xie, X., Zhan, L., Yang, Y., Sharp, D. W., Hu, Z. S., Su, X., Maganti, A., Jiang, C., Lu, W., Zheng, H., Bosenberg, M. W., Mehnert, J. M., Guo, J. Y., Lattime, E., Rabinowitz, J. D. & White, E., Nov 22 2018, In: Nature. 563, 7732, p. 569-573 5 p.Rutgers, The State University, Princeton University
Research output: Contribution to journal › Article › peer-review
Open Access119 Scopus citations -
Four Key Steps Control Glycolytic Flux in Mammalian Cells
Tanner, L. B., Goglia, A. G., Wei, M. H., Sehgal, T., Parsons, L. R., Park, J. O., White, E., Toettcher, J. E. & Rabinowitz, J. D., Jul 25 2018, In: Cell Systems. 7, 1, p. 49-62.e8Rutgers, The State University, Princeton University
Research output: Contribution to journal › Article › peer-review
Open Access83 Scopus citations -
Immune activation and benefit from avelumab in EBV-positive gastric cancer
Panda, A., Mehnert, J. M., Hirshfield, K. M., Riedlinger, G., Damare, S., Saunders, T., Kane, M., Sokol, L., Stein, M. N., Poplin, E., Rodriguez-Rodriguez, L., Silk, A. W., Chan, N., Malhotra, J., Frankel, M., Kaufman, H. L., Ali, S., Ross, J. S., White, E. P. & Bhanot, G. & 1 others, , Mar 1 2018, In: Journal of the National Cancer Institute. 110, 3, p. 316-320 5 p.Research output: Contribution to journal › Article › peer-review
Open Access65 Scopus citations -
Quantitative Analysis of NAD Synthesis-Breakdown Fluxes
Liu, L., Su, X., Quinn, W. J., Hui, S., Krukenberg, K., Frederick, D. W., Redpath, P., Zhan, L., Chellappa, K., White, E., Migaud, M., Mitchison, T. J., Baur, J. A. & Rabinowitz, J. D., May 1 2018, In: Cell Metabolism. 27, 5, p. 1067-1080.e5Rutgers, The State University, Princeton University
Research output: Contribution to journal › Article › peer-review
Open Access115 Scopus citations -
SMAD4 suppresses WNt-driven dedifferentiation and oncogenesis in the differentiated gut epithelium
Perekatt, A. O., Shah, P. P., Cheung, S., Jariwala, N., Wu, A., Gandhi, V., Kumar, N., Feng, Q., Patel, N., Chen, L., Joshi, S., Zhou, A., Taketo, M. M., Xing, J., White, E., Gao, N., Gatza, M. L. & Verzi, M. P., Sep 1 2018, In: Cancer Research. 78, 17, p. 4878-4890 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2017
BRAF fusion as a novel mechanism of acquired resistance to vemurafenib in BRAFV600E mutant melanoma
Kulkarni, A., Al-Hraishawi, H., Simhadri, S., Hirshfield, K. M., Chen, S., Jeyamohan, C., Sokol, L., Ali, S., Teo, M. L., White, E., Rodriguez-Rodriguez, L., Mehnert, J. M. & Ganesan, S., Sep 15 2017, In: Clinical Cancer Research. 23, 18, p. 5631-5638 8 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
Glucose feeds the TCA cycle via circulating lactate
Hui, S., Ghergurovich, J. M., Morscher, R. J., Jang, C., Teng, X., Lu, W., Esparza, L. A., Reya, T., Zhan, L., Yanxiang Guo, J., White, E. & Rabinowitz, J. D., Nov 2 2017, In: Nature. 551, 7678, p. 115-118 4 p.Rutgers, The State University, Princeton University
Research output: Contribution to journal › Article › peer-review
Open Access443 Scopus citations -
Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression
Liu, J., Zhang, C., Zhao, Y., Yue, X., Wu, H., Huang, S., Chen, J., Tomsky, K., Xie, H., Khella, C. A., Gatza, M. L., Xia, D., Gao, J., White, E., Haffty, B. G., Hu, W. & Feng, Z., Dec 1 2017, In: Nature communications. 8, 1, 1823.Research output: Contribution to journal › Article › peer-review
Open Access68 Scopus citations -
Regulation of spindle integrity and mitotic fidelity by BCCIP
Huhn, S. C., Liu, J., Ye, C., Lu, H., Jiang, X., Feng, X., Ganesan, S., White, E. & Shen, Z., Aug 17 2017, In: Oncogene. 36, 33, p. 4750-4766 17 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
2016
Atg7 cooperates with Pten loss to drive prostate cancer tumor growth
Banach-Petrosky, W., Abate-Shen, C., Shen, M. M., White, E. & Dipaola, R. S., Feb 15 2016, In: Genes and Development. 30, 4, p. 399-407 9 p.Research output: Contribution to journal › Article › peer-review
Open Access54 Scopus citations -
Autophagy, metabolism, and cancer
Guo, J. Y. & White, E., 2016, In: Cold Spring Harbor symposia on quantitative biology. 81, 1, p. 73-78 6 p.Research output: Contribution to journal › Article › peer-review
Open Access86 Scopus citations -
Autophagy and p53
White, E., Apr 2016, In: Cold Spring Harbor Perspectives in Medicine. 6, 4, a026120.Research output: Contribution to journal › Article › peer-review
Open Access118 Scopus citations -
Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells
Guo, J. Y., Teng, X., Laddha, S. V., Ma, S., Van Nostrand, S. C., Yang, Y., Khor, S., Chan, C. S., Rabinowitz, J. D. & White, E., Aug 1 2016, In: Genes and Development. 30, 15, p. 1704-1717 14 p.Rutgers, The State University, Princeton University
Research output: Contribution to journal › Article › peer-review
Open Access151 Scopus citations -
AYY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis
Kumar, N., Srivillibhuthur, M., Joshi, S., Walton, K. D., Zhou, A., Faller, W. J., Perekatt, A. O., Sansom, O. J., Gumucio, D. L., Xing, J., Bonder, E. M., Gao, N., White, E. & Verzi, M. P., Oct 15 2016, In: Development (Cambridge). 143, 20, p. 3711-3722 12 p.Rutgers, The State University, Stevens Institute of Technology
Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Elevated p62/SQS TM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide
Wang, C., Yeo, S., Karsli-Uzunbas, G., White, E., Mizushima, N., Virgin, H. W. & Guan, J. L., 2016, In: Journal of Cell Biology. 212, 5, p. 545-560 16 p.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
Paradoxical roles of elongation factor-2 kinase in stem cell survival
Liao, Y., Chu, H. P., Hu, Z., Merkin, J. J., Chen, J., Liu, Z., Degenhardt, K., White, E. & Ryazanov, A. G., Sep 9 2016, In: Journal of Biological Chemistry. 291, 37, p. 19545-19557 13 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
2015
Aneuploidy-induced cellular stresses limit autophagic degradation
Santaguida, S., Vasile, E., White, E. & Amon, A., Oct 1 2015, In: Genes and Development. 29, 19, p. 2010-2021 12 p.Research output: Contribution to journal › Article › peer-review
Open Access69 Scopus citations -
Atg7 overcomes senescence and promotes growth of BrafV600E-driven melanoma
Xie, X., Koh, J. Y., Price, S., White, E. & Mehnert, J. M., Apr 1 2015, In: Cancer Discovery. 5, 4, p. 410-423 14 p.Research output: Contribution to journal › Article › peer-review
Open Access106 Scopus citations -
Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening
Strohecker, A. M., Joshi, S., Possemato, R., Abraham, R. T., Sabatini, D. M. & White, E., Nov 5 2015, In: Oncogene. 34, 45, p. 5662-5676 15 p.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer
Zhang, Y., Wang, X., Qin, X., Liu, F., White, E. & Zheng, X. F. S., Dec 1 2015, In: EBioMedicine. 2, 12, p. 1944-1956 13 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis
Joshi, S., Tolkunov, D., Aviv, H., Hakimi, A. A., Yao, M., Hsieh, J. J., Ganesan, S., Chan, C. S. & White, E., Dec 1 2015, In: Cell Reports. 13, 9, p. 1895-1908 14 p.Research output: Contribution to journal › Article › peer-review
Open Access82 Scopus citations -
2014
An autophagy-dependent anticancer immune response determines the efficacy of melanoma chemotherapy
Michaud, M., Xie, X., Pedro, J. M. B. S., Zitvogel, L., White, E. & Kroemer, G., 2014, In: OncoImmunology. 3, 7, e944047.Research output: Contribution to journal › Article › peer-review
Open Access54 Scopus citations -
Autophagy is required for glucose homeostasis and lung tumor maintenance
Karsli-Uzunbas, G., Guo, J. Y., Price, S., Teng, X., Laddha, S. V., Khor, S., Kalaany, N. Y., Jacks, T., Chan, C. S., Rabinowitz, J. D. & White, E., Aug 2014, In: Cancer Discovery. 4, 8, p. 915-927 13 p.Rutgers, The State University, Princeton University
Research output: Contribution to journal › Article › peer-review
Open Access281 Scopus citations -
Functional Role of Autophagy-Mediated Proteome Remodeling in Cell Survival Signaling and Innate Immunity
Mathew, R., Khor, S., Hackett, S. R., Rabinowitz, J. D., Perlman, D. H. & White, E., Sep 18 2014, In: Molecular cell. 55, 6, p. 916-930 15 p.Rutgers, The State University, Princeton University
Research output: Contribution to journal › Article › peer-review
Open Access67 Scopus citations -
Mode of action of diterpene and characterization of related metabolites from the soft coral, Xeniaelongata
Andrianasolo, E. H., Haramaty, L., White, E., Lutz, R. & Falkowski, P., Feb 2014, In: Marine Drugs. 12, 2, p. 1102-1115 14 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Mutational landscape of the essential autophagy gene BECN1 in human cancers
Laddha, S. V., Ganesan, S., Chan, C. S. & White, E., Apr 2014, In: Molecular Cancer Research. 12, 4, p. 485-490 6 p.Research output: Contribution to journal › Article › peer-review
Open Access119 Scopus citations -
Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression
Liu, Z., Chen, P., Gao, H., Gu, Y., Yang, J., Peng, H., Xu, X., Wang, H., Yang, M., Liu, X., Fan, L., Chen, S., Zhou, J., Sun, Y., Ruan, K., Cheng, S., Komatsu, M., White, E., Li, L. & Ji, H. & 2 others, , Jul 14 2014, In: Cancer Cell. 26, 1, p. 106-120 15 p.Research output: Contribution to journal › Article › peer-review
Open Access126 Scopus citations