Projects per year
Personal profile
Research interests
Research Expertise:
Epigenetics | Genomics | Histone modifications
My research interests are in the field of Epigenetics, which I approach by working to identify the epigenetic marks and molecular mechanisms responsible for causing and maintaining the inheritance of acquired states.
Investigating the capacity of conserved protein catalytic domains to establish and maintain epigenetic modifications in S. cerevisiae with the ultimate goal establishing the causal role of histone packaging in regulating gene expression.
Specifically, my laboratory has created a suite of fusion proteins using CRISPR technology to target H3K9me to eGFP tagged endogenous S. cerevisiae genes which we interrogate expression levels using qRT-PCR as flow cytometry.
Testing the hypothesis that mammalian spermatic chromatin is highly organized and that this patterning can function to drive Transgenerational Epigenetic Inheritance. Determining the genome-wide organization of chromatin in germ cells using genomic and bioinformatics approaches. We are currently working with previously/externally generated datasets but will also be investigating spermatic chromatin in the context of Ctcf mutant mice at Rowan University as this project matures.
Member of:
American Society for Biochemistry and Molecular Biology (www.asbmb.org)
Genetics Society of America (www.genetics-gsa.org)
Sigma Xi (www.sigmaxi.org)
Education/Academic qualification
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Projects
- 1 Active
Research Output
Cationic Molecular Umbrellas as Antibacterial Agents with Remarkable Cell-Type Selectivity
Chen, A., Karanastasis, A., Casey, K. R., Necelis, M., Carone, B. R., Caputo, G. A. & Palermo, E. F., Jan 1 2020, (Accepted/In press) In : ACS Applied Materials and Interfaces.Research output: Contribution to journal › Review article
Correlating lipid membrane permeabilities of imidazolium ionic liquids with their cytotoxicities on yeast, bacterial, and mammalian cells
Cook, K., Tarnawsky, K., Swinton, A. J., Yang, D. D., Senetra, A. S., Caputo, G. A., Carone, B. R. & Vaden, T. D., Jun 2019, In : Biomolecules. 9, 6, 251.Research output: Contribution to journal › Article
Open Access
1
Scopus
citations
Sequence and Dispersity Are Determinants of Photodynamic Antibacterial Activity Exerted by Peptidomimetic Oligo(thiophene)s
Zhou, Z., Ergene, C., Lee, J. Y., Shirley, D. J., Carone, B. R., Caputo, G. A. & Palermo, E. F., Jan 16 2019, In : ACS Applied Materials and Interfaces. 11, 2, p. 1896-1906 11 p.Research output: Contribution to journal › Article
6
Scopus
citations
Antimicrobial activity of a porphyrin binding peptide
Shirley, D. J., Chrom, C. L., Richards, E. A., Carone, B. R. & Caputo, G. A., Jul 2018, In : Peptide Science. 110, 4, e24074.Research output: Contribution to journal › Article
4
Scopus
citations
Role of cationic side chains in the antimicrobial activity of C18G
Kohn, E. M., Shirley, D. J., Arotsky, L., Picciano, A. M., Ridgway, Z., Urban, M. W., Carone, B. R. & Caputo, G. A., Jan 1 2018, In : Molecules. 23, 2, 329.Research output: Contribution to journal › Article
11
Scopus
citations
Press / Media
INTERDISCIPLINARY RESEARCH AWARDED AT INTEL INTERNATIONAL SCIENCE AND ENGINEERING FAIR
5/18/18
1 item of Media coverage
Press/Media: Press / Media