Projects per year
Personal profile
Research interests
Research Expertise:
Epigenetics | Genomics | Histone modifications
My research interests are in the field of Epigenetics, which I approach by working to identify the epigenetic marks and molecular mechanisms responsible for causing and maintaining the inheritance of acquired states.
Investigating the capacity of conserved protein catalytic domains to establish and maintain epigenetic modifications in S. cerevisiae with the ultimate goal establishing the causal role of histone packaging in regulating gene expression.
Specifically, my laboratory has created a suite of fusion proteins using CRISPR technology to target H3K9me to eGFP tagged endogenous S. cerevisiae genes which we interrogate expression levels using qRT-PCR as flow cytometry.
Testing the hypothesis that mammalian spermatic chromatin is highly organized and that this patterning can function to drive Transgenerational Epigenetic Inheritance. Determining the genome-wide organization of chromatin in germ cells using genomic and bioinformatics approaches. We are currently working with previously/externally generated datasets but will also be investigating spermatic chromatin in the context of Ctcf mutant mice at Rowan University as this project matures.
Member of:
American Society for Biochemistry and Molecular Biology (www.asbmb.org)
Genetics Society of America (www.genetics-gsa.org)
Sigma Xi (www.sigmaxi.org)
Education/Academic qualification
Doctor of Philosophy, doctorate, University of Connecticut
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Collaborations and top research areas from the last five years
Projects
- 2 Finished
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Andor Dragonfly 201 Spinning Disk Confocal Microscope System
Carone, B. (PI)
4/15/22 → 4/14/23
Project: Other project
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The role of CTCF in establishing and maintaining chromatin architecture during M. musculus spermatogenesis
Carone, B. (PI)
9/19/19 → 8/31/23
Project: Other project
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Lipid bilayer permeabilities and antibiotic effects of tetramethylguanidinium and choline fatty acid ionic liquids
Dutta, A., Burrell, B., Prajapati, E., Cottle, S., Maurer, H. Y., Urban, M. J., Pennock, S. R., Muhamed, A. M., Harris, J., Flores, Y., Staman, L., Carone, B. R., Caputo, G. A. & Vaden, T. D., Jan 2025, In: Biochimica et Biophysica Acta - Biomembranes. 1867, 1, 184393.Research output: Contribution to journal › Article › peer-review
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MNase-seq to Identify Genome-Wide DNA-Protein Interactions
Carone, B. R., 2025, Methods in Molecular Biology. Humana Press Inc., p. 99-109 11 p. (Methods in Molecular Biology; vol. 2866).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Locus-specific differential expression of human satellite sequences in the nuclei of cancer cells and heat-shocked cells
Rabeler, C., Paterna, N., Potluri, R., D’Alessandro, L. R., Bhatia, A., Chen, S. Y., Lee, J., Abeje, B., Lipchin, B., Carone, B. R. & Carone, D. M., 2024, In: Nucleus. 15, 1, 2431239.Research output: Contribution to journal › Article › peer-review
Open Access -
Trehalose enhances mitochondria deficits in human NPC1 mutant fibroblasts but disrupts mouse Purkinje cell dendritic growth ex vivo
MacLeod, C. M., Yousufzai, F. A. K., Spencer, L. T., Kim, S., Rivera-Rosario, L. A., Barrera, Z. D., Walsh, L., Krummenacher, C., Carone, B. & Soto, I., Nov 2023, In: PLoS One. 18, 11 November, e0294312.Research output: Contribution to journal › Article › peer-review
Open Access -
Detecting Fear-Memory-Related Genes from Neuronal scRNA-seq Data by Diverse Distributions and Bhattacharyya Distance
Zhang, S., Xie, L., Cui, Y., Carone, B. R. & Chen, Y., Aug 2022, In: Biomolecules. 12, 8, 1130.Research output: Contribution to journal › Article › peer-review
Open Access