Benjamin Carone

Personal profile

Research interests

Research Expertise:
Epigenetics | Genomics | Histone modifications

My research interests are in the field of Epigenetics, which I approach by working to identify the epigenetic marks and molecular mechanisms responsible for causing and maintaining the inheritance of acquired states.

Investigating the capacity of conserved protein catalytic domains to establish and maintain epigenetic modifications in S. cerevisiae with the ultimate goal establishing the causal role of histone packaging in regulating gene expression.

Specifically, my laboratory has created a suite of fusion proteins using CRISPR technology to target H3K9me to eGFP tagged endogenous S. cerevisiae genes which we interrogate expression levels using qRT-PCR as flow cytometry.

Testing the hypothesis that mammalian spermatic chromatin is highly organized and that this patterning can function to drive Transgenerational Epigenetic Inheritance. Determining the genome-wide organization of chromatin in germ cells using genomic and bioinformatics approaches. We are currently working with previously/externally generated datasets but will also be investigating spermatic chromatin in the context of Ctcf mutant mice at Rowan University as this project matures.

Member of:
American Society for Biochemistry and Molecular Biology (www.asbmb.org)
Genetics Society of America (www.genetics-gsa.org)
Sigma Xi (www.sigmaxi.org)

Education/Academic qualification

Doctor of Philosophy, doctorate

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Projects

1 Active

The role of CTCF in establishing and maintaining chromatin architecture during M. musculus spermatogenesis

Carone, B.

National Institutes of Health

9/19/19 → 11/30/22

Rowan University

Project: Other project

Research Output

1684 Citations
10 h-Index
15 Article
1 Short survey
1 Review article

Cationic Molecular Umbrellas as Antibacterial Agents with Remarkable Cell-Type Selectivity

Chen, A., Karanastasis, A., Casey, K. R., Necelis, M., Carone, B. R., Caputo, G. A. & Palermo, E. F., Jan 1 2020, (Accepted/In press) In : ACS Applied Materials and Interfaces.

Rowan University

Research output: Contribution to journal › Review article

1 Scopus citations

Correlating lipid membrane permeabilities of imidazolium ionic liquids with their cytotoxicities on yeast, bacterial, and mammalian cells

Cook, K., Tarnawsky, K., Swinton, A. J., Yang, D. D., Senetra, A. S., Caputo, G. A., Carone, B. R. & Vaden, T. D., Jun 2019, In : Biomolecules. 9, 6, 251.

Rowan University

Research output: Contribution to journal › Article

Open Access

2 Scopus citations

Sequence and Dispersity Are Determinants of Photodynamic Antibacterial Activity Exerted by Peptidomimetic Oligo(thiophene)s

Zhou, Z., Ergene, C., Lee, J. Y., Shirley, D. J., Carone, B. R., Caputo, G. A. & Palermo, E. F., Jan 16 2019, In : ACS Applied Materials and Interfaces. 11, 2, p. 1896-1906 11 p.

Rowan University

Research output: Contribution to journal › Article

7 Scopus citations

Antimicrobial activity of a porphyrin binding peptide

Shirley, D. J., Chrom, C. L., Richards, E. A., Carone, B. R. & Caputo, G. A., Jul 2018, In : Peptide Science. 110, 4, e24074.

Rowan University

Research output: Contribution to journal › Article

4 Scopus citations

Role of cationic side chains in the antimicrobial activity of C18G

Kohn, E. M., Shirley, D. J., Arotsky, L., Picciano, A. M., Ridgway, Z., Urban, M. W., Carone, B. R. & Caputo, G. A., Jan 1 2018, In : Molecules. 23, 2, 329.

Rowan University

Research output: Contribution to journal › Article

13 Scopus citations

Press / Media

INTERDISCIPLINARY RESEARCH AWARDED AT INTEL INTERNATIONAL SCIENCE AND ENGINEERING FAIR

Benjamin Carone

5/18/18

1 item of Media coverage

Rowan University

Press/Media: Press / Media