• 200 Citations
  • 4 h-Index
19982022

Research output per year

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Research Output

2020

Aging and longevity: Short and sweet

Murphy, C. T., Feb 2020, In : eLife. 9, e55220.

Princeton University

Research output: Contribution to journalArticle

Open Access

Novel High-Throughput Screening Method for Parkinson's Phenotypes Using C. elegans

Murphy, C., Sohrabi, S., Mor, D., Kaletsky, R. & Keyes, W., Feb 25 2020

Princeton University

Research output: Innovation

2019

A PBX/MEIS Complex Balances Reproduction and Somatic Resilience

Heimbucher, T. & Murphy, C. T., Apr 22 2019, In : Developmental cell. 49, 2, p. 157-158 2 p.

Princeton University

Research output: Contribution to journalShort survey

Being open to the unexpected

Murphy, C. T., Nov 1 2019, In : Molecular biology of the cell. 30, 23, p. 2862-2864 3 p.

Princeton University

Research output: Contribution to journalArticle

Open Access

Gut feelings: microRNAs tune protein quality control and ageing to odours

Kaletsky, R. & Murphy, C. T., Mar 1 2019, In : Nature Metabolism. 1, 3, p. 306-307 2 p.

Princeton University

Research output: Contribution to journalArticle

Open Access

Investigating mechanisms that control ubiquitin-mediated DAF-16/FOXO protein turnover

Heimbucher, T. & Murphy, C. T., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 41-49 9 p. (Methods in Molecular Biology; vol. 1890).

Princeton University

Research output: Chapter in Book/Report/Conference proceedingChapter

Nervous system-wide profiling of presynaptic mRNAs reveals regulators of associative memory

Arey, R. N., Kaletsky, R. & Murphy, C. T., Dec 1 2019, In : Scientific reports. 9, 1, 20314.

Princeton University

Research output: Contribution to journalArticle

Open Access

Piwi/PRG-1 Argonaute and TGF-β Mediate Transgenerational Learned Pathogenic Avoidance

Moore, R. S., Kaletsky, R. & Murphy, C. T., Jun 13 2019, In : Cell. 177, 7, p. 1827-1841.e12

Princeton University

Research output: Contribution to journalArticle

2018

Activation of G αq Signaling Enhances Memory Consolidation and Slows Cognitive Decline

Arey, R. N., Stein, G. M., Kaletsky, R., Kauffman, A. & Murphy, C. T., May 2 2018, In : Neuron. 98, 3, p. 562-574.e5

Princeton University

Research output: Contribution to journalArticle

An integrative tissue-network approach to identify and test human disease genes

Yao, V., Kaletsky, R., Keyes, W., Mor, D. E., Wong, A. K., Sohrabi, S., Murphy, C. T. & Troyanskaya, O. G., Dec 1 2018, In : Nature biotechnology. 36, 11, p. 1091-1105 15 p.

Princeton University

Research output: Contribution to journalArticle

Caenorhabditis elegans sperm carry a histone-based epigenetic memory of both spermatogenesis and oogenesis

Tabuchi, T. M., Rechtsteiner, A., Jeffers, T. E., Egelhofer, T. A., Murphy, C. T. & Strome, S., Dec 1 2018, In : Nature communications. 9, 1, 4310.

Princeton University

Research output: Contribution to journalArticle

Insulin Signaling Regulates Oocyte Quality Maintenance with Age via Cathepsin B Activity

Templeman, N. M., Luo, S., Kaletsky, R., Shi, C., Ashraf, J., Keyes, W. & Murphy, C. T., Mar 5 2018, In : Current Biology. 28, 5, p. 753-760.e4

Princeton University

Research output: Contribution to journalArticle

Regulation of reproduction and longevity by nutrient-sensing pathways

Templeman, N. M. & Murphy, C. T., Jan 1 2018, In : Journal of Cell Biology. 217, 1, p. 93-106 14 p.

Princeton University

Research output: Contribution to journalReview article

The nematode Caenorhabditis elegans as a model for aging research

Mack, H. I. D., Heimbucher, T. & Murphy, C. T., Mar 1 2018, In : Drug Discovery Today: Disease Models. 27, p. 3-13 11 p.

Princeton University

Research output: Contribution to journalReview article

Transcriptome analysis of adult Caenorhabditis elegans cells reveals tissue-specific gene and isoform expression

Kaletsky, R., Yao, V., Williams, A., Runnels, A. M., Tadych, A., Zhou, S., Troyanskaya, O. G. & Murphy, C. T., Aug 2018, In : PLoS genetics. 14, 8, e1007559.

Princeton University

Research output: Contribution to journalArticle

2017

Conserved regulators of cognitive aging: From worms to humans

Arey, R. N. & Murphy, C. T., Mar 30 2017, In : Behavioural Brain Research. 322, p. 299-310 12 p.

Princeton University

Research output: Contribution to journalArticle

Mating and male pheromone kill Caenorhabditis males through distinct mechanisms

Shi, C., Runnels, A. M. & Murphy, C. T., Mar 14 2017, In : eLife. 6, e23493.

Princeton University

Research output: Contribution to journalArticle

RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. Elegans

Son, H. G., Seo, M., Ham, S., Hwang, W., Lee, D., An, S. W. A., Artan, M., Seo, K., Kaletsky, R., Arey, R. N., Ryu, Y., Ha, C. M., Kim, Y. K., Murphy, C. T., Roh, T. Y., Nam, H. G. & Lee, S. J. V., Mar 9 2017, In : Nature communications. 8, 14749.

Princeton University

Research output: Contribution to journalArticle

2016

Cell-Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expression

Crocker, A., Guan, X. J., Murphy, C. T. & Murthy, M., May 17 2016, In : Cell Reports. 15, 7, p. 1580-1596 17 p.

Princeton University

Research output: Contribution to journalArticle

30 Scopus citations

Feeding the germline

Shi, C. & Murphy, C. T., Feb 1 2016, In : Genes and Development. 30, 3, p. 249-250 2 p.

Princeton University

Research output: Contribution to journalArticle

The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators

Kaletsky, R., Lakhina, V., Arey, R., Williams, A., Landis, J., Ashraf, J. & Murphy, C. T., Jan 7 2016, In : Nature. 529, 7584, p. 92-96 5 p.

Princeton University

Research output: Contribution to journalArticle

62 Scopus citations

The Neuronal Kinesin UNC-104/KIF1A is a Key Regulator of Synaptic Aging and Insulin Signaling-Regulated Memory

Li, L. B., Lei, H., Arey, R. N., Li, P., Liu, J., Murphy, C. T., Xu, X. Z. S. & Shen, K., Mar 7 2016, In : Current Biology. 26, 5, p. 605-615 11 p.

Princeton University

Research output: Contribution to journalArticle

2015

A microfluidic device and automatic counting system for the study of C. elegans reproductive aging

Li, S., Stone, H. A. & Murphy, C. T., Jan 21 2015, In : Lab on a chip. 15, 2, p. 524-531 8 p.

Princeton University

Research output: Contribution to journalArticle

C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation

Hahm, J. H., Kim, S., Diloreto, R., Shi, C., Lee, S. J. V., Murphy, C. T. & Nam, H. G., Nov 20 2015, In : Nature communications. 6, 8919.

Princeton University

Research output: Contribution to journalArticle

54 Scopus citations

Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity

Ewald, C. Y., Landis, J. N., Abate, J. P., Murphy, C. T. & Blackwell, T. K., Mar 5 2015, In : Nature. 519, 7541, p. 97-101 5 p.

Princeton University

Research output: Contribution to journalArticle

For longevity, perception is everything

Lakhina, V. & Murphy, C. T., Feb 26 2015, In : Cell. 160, 5, p. 807-809 3 p.

Princeton University

Research output: Contribution to journalShort survey

Genome Sequencing Fishes out Longevity Genes

Lakhina, V. & Murphy, C. T., Dec 3 2015, In : Cell. 163, 6, p. 1312-1313 2 p.

Princeton University

Research output: Contribution to journalShort survey

Genome-wide functional analysis of CREB/Long-term memory-dependent transcription reveals distinct basal and memory gene expression programs

Lakhina, V., Arey, R. N., Kaletsky, R., Kauffman, A., Stein, G., Keyes, W., Xu, D. & Murphy, C. T., Jan 21 2015, In : Neuron. 85, 2, p. 330-345 16 p.

Princeton University

Research output: Contribution to journalArticle

54 Scopus citations

The cell biology of aging

DiLoreto, R. & Murphy, C. T., Dec 15 2015, In : Molecular biology of the cell. 26, 25, p. 4524-4531 8 p.

Princeton University

Research output: Contribution to journalReview article

2014

An Insulin-to-Insulin Regulatory Network Orchestrates Phenotypic Specificity in Development and Physiology

Fernandes de Abreu, D. A., Caballero, A., Fardel, P., Stroustrup, N., Chen, Z., Lee, K. H., Keyes, W. D., Nash, Z. M., López-Moyado, I. F., Vaggi, F., Cornils, A., Regenass, M., Neagu, A., Ostojic, I., Liu, C., Cho, Y., Sifoglu, D., Shen, Y., Fontana, W., Lu, H. & 8 others, Csikasz-Nagy, A., Murphy, C. T., Antebi, A., Blanc, E., Apfeld, J., Zhang, Y., Alcedo, J. & Ch'ng, Q. L., Mar 2014, In : PLoS genetics. 10, 3, e1004225.

Princeton University

Research output: Contribution to journalArticle

DAF-16 and PQM-1: Partners in longevity

Tepper, R. G., Murphy, C. T. & Bussemaker, H. J., Jan 2014, In : Aging. 6, 1, p. 5-6 2 p.

Princeton University

Research output: Contribution to journalEditorial

Mating induces shrinking and death in Caenorhabditis mothers

Shi, C. & Murphy, C. T., Jan 1 2014, In : Science. 343, 6170, p. 536-540 5 p.

Princeton University

Research output: Contribution to journalArticle

2013

A new system for comparative functional genomics of Saccharomyces yeasts

Caudy, A. A., Guan, Y., Jia, Y., Hansen, C., DeSevo, C., Hayes, A. P., Agee, J., Alvarez-Dominguez, J. R., Arellano, H., Barrett, D., Bauerle, C., Bisaria, N., Bradley, P. H., Scott Breunig, J., Bush, E., Cappel, D., Capra, E., Chen, W., Clore, J., Combs, P. A. & 54 others, Doucette, C., Demuren, O., Fellowes, P., Freeman, S., Frenkel, E., Gadala-Maria, D., Gawande, R., Glass, D., Grossberg, S., Gupta, A., Hammonds-Odie, L., Hoisos, A., Hsi, J., Hsu, Y. H. H., Inukai, S., Karczewski, K. J., Ke, X., Kojima, M., Leachman, S., Lieber, D., Liebowitz, A., Liu, J., Liu, Y., Martin, T., Mena, J., Mendoza, R., Myhrvold, C., Millian, C., Pfau, S., Raj, S., Rich, M., Rokicki, J., Rounds, W., Salazar, M., Salesi, M., Sharma, R., Silverman, S., Singer, C., Sinha, S., Staller, M., Stern, P., Tang, H., Weeks, S., Weidmann, M., Wolf, A., Young, C., Yuan, J., Crutchfield, C., McClean, M., Murphy, C. T., Llinás, M., Botstein, D., Troyanskaya, O. G. & Dunham, M. J., Sep 17 2013, In : Genetics. 195, 1, p. 275-287 13 p.

Princeton University

Research output: Contribution to journalArticle

Insulin/insulin-like growth factor signaling in C. elegans

Murphy, C. T. & Hu, P. J., Jan 1 2013, In : WormBook : the online review of C. elegans biology. p. 1-43 43 p.

Princeton University

Research output: Contribution to journalReview article

PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity

Tepper, R. G., Ashraf, J., Kaletsky, R., Kleemann, G., Murphy, C. T. & Bussemaker, H. J., Aug 1 2013, In : Cell. 154, 3, p. 676-690 15 p.

Princeton University

Research output: Contribution to journalArticle

2012

Cell biology of disease and aging: A two-way street

Blackstone, C. & Murphy, C. T., Mar 15 2012, In : Molecular biology of the cell. 23, 6, 1 p.

Princeton University

Research output: Contribution to journalArticle

Coleen Murphy: How to stay young at heart, body, and mind

Murphy, C., Apr 30 2012, In : Journal of Cell Biology. 197, 3, p. 342-343 2 p.

Princeton University

Research output: Contribution to journalArticle

The intersection of aging, longevity pathways, and learning and memory in C. elegans

Stein, G. M. & Murphy, C. T., Dec 1 2012, In : Frontiers in Genetics. 3, NOV, Article 259.

Princeton University

Research output: Contribution to journalArticle

2011

C. elegans positive butanone learning, short-term, and long-term associative memory assays

Kauffman, A., Parsons, L., Stein, G., Wills, A., Kaletsky, R. & Murphy, C., Mar 2011, In : Journal of Visualized Experiments. 49, e2490.

Princeton University

Research output: Contribution to journalArticle

Caenorhabditis elegans reproductive aging: Regulation and underlying mechanisms

Luo, S. & Murphy, C. T., Feb 1 2011, In : Genesis. 49, 2, p. 53-65 13 p.

Princeton University

Research output: Contribution to journalReview article

The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO

Rizki, G., Iwata, T. N., Li, J., Riedel, C. G., Picard, C. L., Jan, M., Murphy, C. T. & Lee, S. S., Sep 1 2011, In : PLoS genetics. 7, 9, e1002235.

Princeton University

Research output: Contribution to journalArticle

2010

Aging: MiRacles of longevity?

Murphy, C. T., Dec 21 2010, In : Current Biology. 20, 24, p. R1076-R1078

Princeton University

Research output: Contribution to journalShort survey

Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age

Kauffman, A. L., Ashraf, J. M., orces-Zimmerman, M. R., Landis, J. N. & Murphy, C. T., May 1 2010, In : PLoS biology. 8, 5

Princeton University

Research output: Contribution to journalArticle

Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO

Landis, J. N. & Murphy, C. T., May 1 2010, In : Developmental Dynamics. 239, 5, p. 1405-1412 8 p.

Princeton University

Research output: Contribution to journalReview article

TGF-β and Insulin Signaling Regulate Reproductive Aging via Oocyte and Germline Quality Maintenance

Luo, S., Kleemann, G. A., Ashraf, J. M., Shaw, W. M. & Murphy, C. T., Oct 15 2010, In : Cell. 143, 2, p. 299-312 14 p.

Princeton University

Research output: Contribution to journalArticle

The role of insulin/IGF-like signaling in C. elegans longevity and aging

Kaletsky, R. & Murphy, C. T., Jan 1 2010, In : DMM Disease Models and Mechanisms. 3, 7-8, p. 415-419 5 p.

Princeton University

Research output: Contribution to journalReview article