Projects per year
Personal profile
University profile
Medicinal chemistry research in Dr. David Rotella's lab is a collaborative exercise where we engage other scientists with complimentary interests. Currently, they are engaged in discovery of protein kinase inhibitors for anti infective and anti inflammatory applications, in the discovery of new agents useful for the potential treatment of neurodegenerative diseases and enzyme inhibitors that can be used to treat botulism poisoning. Dr. Rotella is working with others at MSU as well as scientists in other universities and research institutes.
Research interests
Focused on drug discovery for CNS and neglected diseases.
Scholarly Interests
Medicinal chemistry. Drug discovery, hit to lead and lead optimization, medicinal chemistry, CNS, cardiovascular and metabolic disease expertise, intellectual property and expert witness.
Faculty/Media Expert
Expert on Medicinal chemistry, pharmaceuticals, and drug discovery.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Pharmacologic Inhibition of PDE11A for Age-Related Memory Disorders
Rotella, D. (PI), Hoffman, C. S. (CoPI) & Kelly, M. (CoPI)
9/15/20 → 4/30/25
Project: Research project
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Development of inhibitors of P. falciparum cGMP dependent protein kinase (PfPKG) for malaria chemoprevention
Bhanot, P. (PI), Rotella, D. (CoPI) & Siekierka, J. (CoPI)
National Institute of Allergy and Infectious Diseases
8/1/17 → 7/31/21
Project: Research
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Comprehensive Medicinal Chemistry, Fourth Edition, Four Volume Set
Rotella, D. P. & Ward, S. E., Jan 1 2026, Comprehensive Medicinal Chemistry IV. Elsevier, p. 1-3150 3150 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Correction to “Potent, Selective Pyrrolopyrimidine PDE11A4 Inhibitors with Improved Pharmaceutical Properties”
Mahmood, S. U., Boddu, R. K., Eberhard, J., Hoffman, C. S., Gordon, J., Colussi, D., Childers, W., Amurrio, E., Danaher, M., Kelly, M. P. & Rotella, D. P., Apr 9 2026, In: ACS Medicinal Chemistry Letters. 17, 4, p. 952 1 p.Research output: Contribution to journal › Comment/debate
Open Access -
Introduction
Rotella, D. P. & Ward, S. E., Jan 1 2026, Comprehensive Medicinal Chemistry IV. Elsevier, p. xvii-xviiResearch output: Chapter in Book/Report/Conference proceeding › Foreword/postscript
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Potent, Selective Pyrrolopyrimidine PDE11A4 Inhibitors with Improved Pharmaceutical Properties
Mahmood, S. U., Boddu, R. K., Eberhard, J., Hoffman, C. S., Gordon, J., Colussi, D., Childers, W., Amurrio, E., Danaher, M., Kelly, M. P. & Rotella, D. P., Feb 12 2026, In: ACS Medicinal Chemistry Letters. 17, 2, p. 547-553 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Versatile Imidazole Scaffold with Potent Activity against Multiple Apicomplexan Parasites
Khim, M., Montgomery, J., Laureano De Souza, M., Delvillar, M., Weible, L. J., Prabakaran, M., Hulverson, M. A., Eck, T., Bheemanabonia, R. Y., Alday, P. H., Rotella, D. P., Doggett, J. S., Staker, B. L., Ojo, K. K. & Bhanot, P., Jun 13 2025, In: ACS infectious diseases. 11, 6, p. 1497-1507 11 p.Research output: Contribution to journal › Article › peer-review
Open Access