Projects per year
Personal profile
University profile
Dr. David Talaga received his undergraduate degree in chemistry and mathematics from Occidental College and supplemented his interests with graduate courses from Caltech. He started a volunteer tutoring program that significantly increased the number of students show could receive extra help in chemistry and biology. These efforts also enhanced the interaction between student in the earlier and later years of their undergraduate experience. These experiences cemented his interest in research and teaching in physical chemistry.
Dr. Talaga's research program focuses on the heterogeneity in protein conformation, particularly as proteins aggregate into various intermediates that lead to amyloid formation. His research group develops measurements that can distinguish protein conformation through different aggregation states. A significant part of their efforts includes solving experimental and theoretical challenges that arise in measuring and interpreting such heterogeneous systems. These problems not only confound characterization of amyloidogenesis, but also appear in most protein systems, making these ancillary developments important to many other fields.
Research Interests
Protein Folding, Protein and Peptide Conformational Dynamics, Protein Aggregation, Amyloid, Parkinson’s Disease, Amyloidoses, Nanopores, Single Molecule Fluorescence, Ultrafast Spectroscopy, Information Theory, Bayesian Statistics, Global Data Analysis, Statistical Mechanics.
Teaching
General Chemistry, Analytical Chemistry, Physical Chemistry, Spectroscopy, Group Theory, Statistical Mechanics, Statistical Thermodynamics, Biophysical Chemistry, General Education Chemistry.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Projects
- 8 Finished
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INTERFACIALLY ACTIVATED AGGREGATION OF ALPHA-SYNUCLEIN
Talaga, D. (PI)
National Institute of Health (NIH)
3/15/15 → 2/28/18
Project: Research project
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NIRT: Ligand Nanodisplay for Cellular Internalization and Super-Activation
Moghe, P. (PI), Talaga, D. (CoPI), Tsakalakos, T. (CoPI), Roth, C. (CoPI) & Schwarzbauer, J. E. (CoPI)
9/1/06 → 8/31/12
Project: Research project
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NIRT: Ligand Nanodisplay for Cellular Internalization and Super-Activation
Moghe, P. (PI), Talaga, D. (CoPI), Tsakalakos, T. (CoPI), Roth, C. (CoPI) & Schwarzbauer, J. E. (CoPI)
9/1/06 → 8/31/12
Project: Research project
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New statistical tools for single molecule experiments
Talaga, D. (CoPI)
National Institute of General Medical Sciences
8/1/04 → 1/31/11
Project: Research
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EVENTS IN DNA 2 STRUCTURAL CHANGES BY TIME-RESOLVED IR
Talaga, D. (PI)
National Institute of General Medical Sciences
1/1/97 → 12/31/99
Project: Research project
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Aggregation and Oligomerization Characterization of ß-Lactoglobulin Protein Using a Solid-State Nanopore Sensor
Acharjee, M. C., Ledden, B., Thomas, B., He, X., Messina, T., Giurleo, J., Talaga, D. & Li, J., Jan 2024, In: Sensors (Switzerland). 24, 1, 81.Research output: Contribution to journal › Article › peer-review
Open Access -
Erratum: Single-molecule protein unfolding in solid state nanopores (Journal of the American Chemical Society (2009) 131 (9287-9297) DOI: 10.1021/ja901088b)
Talaga, D. S. & Li, J., Sep 4 2013, In: Journal of the American Chemical Society. 135, 35, p. 13220 1 p.Research output: Contribution to journal › Comment/debate
Open Access3 Scopus citations -
Erratum: Determining nanocapillary geometry from electrochemical impedance spectroscopy using a variable topology network circuit model (Analytical Chemistry (2011) 83:2 (533-541) DOI: 10.1021/ac102236k)
Vitarelli, M. J., Prakash, S. & Talaga, D. S., Jul 2 2013, In: Analytical Chemistry. 85, 13, p. 6544 1 p.Rutgers, The State University, Montclair State University
Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Erratum: The distribution of DNA translocation times in solid-state nanopores(Journal of Physics Condensed Matter (2010)22 (454129))
Li, J. & Talaga, D. S., Dec 11 2013, In: Journal of Physics Condensed Matter. 25, 49, 499502.Research output: Contribution to journal › Comment/debate
2 Scopus citations -
Theoretical models for electrochemical impedance spectroscopy and local ζ-potential of unfolded proteins in nanopores
Vitarelli, M. J. & Talaga, D. S., Sep 14 2013, In: Journal of Chemical Physics. 139, 10, 105101.Rutgers, The State University, Montclair State University
Research output: Contribution to journal › Article › peer-review
Open Access