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Research Output

2020

Bile Acids and FXR: Novel Targets for Liver Diseases

Stofan, M. & Guo, G. L., Sep 11 2020, In : Frontiers in Medicine. 7, 544.

Rutgers, The State University

Research output: Contribution to journalReview article

Open Access

Developmental regulation of the gut–liver (FGF19-CYP7A1) axis in neonates

Memon, N., Griffin, I. J., Lee, C. W., Herdt, A., Weinberger, B. I., Hegyi, T., Carayannopoulos, M. O., Aleksunes, L. M. & Guo, G. L., Mar 18 2020, In : Journal of Maternal-Fetal and Neonatal Medicine. 33, 6, p. 987-992 6 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Direct and Indirect Effects of Fibroblast Growth Factor (FGF) 15 and FGF19 on Liver Fibrosis Development

Schumacher, J. D., Kong, B., Wu, J., Rizzolo, D., Armstrong, L. E., Chow, M. D., Goedken, M., Lee, Y. H. & Guo, G. L., Feb 1 2020, In : Hepatology. 71, 2, p. 670-685 16 p.

Rutgers, The State University

Research output: Contribution to journalArticle

5 Scopus citations

Effects of total parenteral nutrition on drug metabolism gene expression in mice

Ferrucci-Da Silva, C., Zhan, L., Shen, J., Kong, B., Campbell, M. J., Memon, N., Hegyi, T., Lu, L. & Guo, G. L., Jan 2020, In : Acta Pharmaceutica Sinica B. 10, 1, p. 153-158 6 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Enhanced alcoholic liver disease in mice with intestine-specific farnesoid X receptor deficiency

Huang, M., Kong, B., Zhang, M., Rizzolo, D., Armstrong, L. E., Schumacher, J. D., Chow, M. D., Lee, Y. H., Joseph, L. B., Stofan, M., Zhang, L. & Guo, G. L., Sep 1 2020, In : Laboratory Investigation. 100, 9, p. 1158-1168 11 p.

Rutgers, The State University

Research output: Contribution to journalArticle

Is CYP2C70 the key to new mouse models to understand bile acids in humans?

Guo, G. L. & Chiang, J. Y. L., Jan 1 2020, In : Journal of lipid research. 61, 3, p. 269-271 3 p.

Rutgers, The State University

Research output: Contribution to journalComment/debate

1 Scopus citations

Sex- and age-dependent effects of maternal organophosphate flame-retardant exposure on neonatal hypothalamic and hepatic gene expression

Adams, S., Wiersielis, K., Yasrebi, A., Conde, K., Armstrong, L., Guo, G. L. & Roepke, T. A., Jun 2020, In : Reproductive Toxicology. 94, p. 65-74 10 p.

Rutgers, The State University

Research output: Contribution to journalArticle

2 Scopus citations
2019
Open Access
4 Scopus citations

Age modulates liver responses to asparaginase-induced amino acid stress in mice

Nikonorova, I. A., Zhu, Q., Signore, C. C., Mirek, E. T., Jonsson, W. O., Kong, B., Guo, G. L., Belden, W. J. & Anthony, T. X. G., Sep 20 2019, In : Journal of Biological Chemistry. 294, 38, p. 12864-13875 1012 p.

Rutgers, The State University

Research output: Contribution to journalReview article

Open Access

Altered gut-liver axis in liver diseases

Zhou, H., Bajaj, J. S. & Guo, G. L., Mar 2019, In : Liver Research. 3, 1, p. 1-2 2 p.

Rutgers, The State University

Research output: Contribution to journalEditorial

Open Access

Bile Acid Homeostasis in a Cholesterol 7α-Hydroxylase and Sterol 27-Hydroxylase Double Knockout Mouse Model

Rizzolo, D., Buckley, K., Kong, B., Zhan, L., Shen, J., Stofan, M., Brinker, A., Goedken, M., Buckley, B. & Guo, G. L., Jul 2019, In : Hepatology. 70, 1, p. 389-402 14 p.

Rutgers, The State University

Research output: Contribution to journalArticle

3 Scopus citations

Epigenetic Regulation of the Ontogenic Expression of the Dopamine Transporter

Green, A. L., Eid, A., Zhan, L., Zarbl, H., Guo, G. L. & Richardson, J. R., Nov 4 2019, In : Frontiers in Genetics. 10, 1099.

Rutgers, The State University

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

FXR deficiency alters bile acid pool composition and exacerbates chronic alcohol induced liver injury

Kong, B., Zhang, M., Huang, M., Rizzolo, D., Armstrong, L. E., Schumacher, J. D., Chow, M. D., Lee, Y. H. & Guo, G. L., Apr 2019, In : Digestive and Liver Disease. 51, 4, p. 570-576 7 p.

Rutgers, The State University

Research output: Contribution to journalArticle

6 Scopus citations

Is This the Time to Reconsider the Names for Xenobiotic Nuclear Receptors?

Kong, B. & Guo, G. L., Jan 2019, In : Hepatology. 69, 1, p. 16-18 3 p.

Rutgers, The State University

Research output: Contribution to journalEditorial

1 Scopus citations

Pharmacologic Modulation of Bile Acid-FXR-FGF15/FGF19 Pathway for the Treatment of Nonalcoholic Steatohepatitis

Schumacher, J. D. & Guo, G. L., 2019, Handbook of Experimental Pharmacology. Springer New York LLC, p. 325-357 33 p. (Handbook of Experimental Pharmacology; vol. 256).

Rutgers, The State University

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Phosphorylation of hepatic farnesoid X receptor by FGF19 signaling–activated Src maintains cholesterol levels and protects from atherosclerosis

Byun, S., Jung, H., Chen, J., Kim, Y. C., Kim, D. H., Kong, B., Guo, G., Kemper, B. & Kemper, J. K., Jan 1 2019, In : Journal of Biological Chemistry. 294, 22, p. 8732-8744 13 p.

Rutgers, The State University

Research output: Contribution to journalArticle

5 Scopus citations

Small Heterodimer Partner and Fibroblast Growth Factor 19 Inhibit Expression of NPC1L1 in Mouse Intestine and Cholesterol Absorption

Kim, Y. C., Byun, S., Seok, S., Guo, G., Xu, H. E., Kemper, B. & Kemper, J. K., Mar 2019, In : Gastroenterology. 156, 4, p. 1052-1065 14 p.

Rutgers, The State University

Research output: Contribution to journalArticle

7 Scopus citations
6 Scopus citations
2018

AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle

Kim, Y. C., Seok, S., Byun, S., Kong, B., Zhang, Y., Guo, G., Xie, W., Ma, J., Kemper, B. & Kemper, J. K., Dec 1 2018, In : Nature communications. 9, 1, 540.

Rutgers, The State University

Research output: Contribution to journalArticle

12 Scopus citations

Diminished gallbladder filling, increased fecal bile acids, and promotion of colon epithelial cell proliferation and neoplasia in fibroblast growth factor 15-deficient mice

Cheng, K., Metry, M., Felton, J., Shang, A. C., Drachenberg, C. B., Xu, S., Zhan, M., Schumacher, J., Guo, G. L., Polli, J. E. & Raufman, J. P., May 22 2018, In : Oncotarget. 9, 39, p. 25572-25585 14 p.

Rutgers, The State University

Research output: Contribution to journalArticle

7 Scopus citations

Farnesoid X receptor signaling activates the hepatic X-box binding protein 1 pathway in vitro and in mice

Liu, X., Guo, G. L., Kong, B., Hilburn, D. B., Hubchak, S. C., Park, S., LeCuyer, B., Hsieh, A., Wang, L., Fang, D. & Green, R. M., Jul 2018, In : Hepatology. 68, 1, p. 304-316 13 p.

Rutgers, The State University

Research output: Contribution to journalArticle

6 Scopus citations

Fetal minamata disease: A human episode of congenital methylmercury poisoning

Dos Santos, A. A., Chang, L. W., Guo, G. L. & Aschner, M., Jan 1 2018, Handbook of Developmental Neurotoxicology. Elsevier, p. 399-406 8 p.

Rutgers, The State University

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Fibroblast growth factor 15 deficiency increases susceptibility but does not improve repair to acetaminophen-induced liver injury in mice

Huang, M., Williams, J., Kong, B., Zhu, Y., Li, G., Zhu, Z. & Guo, G. L., Feb 1 2018, In : Digestive and Liver Disease. 50, 2, p. 175-180 6 p.

Rutgers, The State University

Research output: Contribution to journalArticle

5 Scopus citations

Fibroblast Growth Factor 15–Dependent and Bile Acid–Independent Promotion of Liver Regeneration in Mice

Kong, B., Sun, R., Huang, M., Chow, M. D., Zhong, X. B., Xie, W., Lee, Y. H. & Guo, G. L., Nov 2018, In : Hepatology. 68, 5, p. 1961-1976 16 p.

Rutgers, The State University

Research output: Contribution to journalArticle

10 Scopus citations

FXR deletion in hepatocytes does not affect the severity of alcoholic liver disease in mice

Zhang, M., Kong, B., Huang, M., Wan, R., Armstrong, L. E., Schumacher, J. D., Rizzolo, D., Chow, M. D., Lee, Y. H. & Guo, G. L., Oct 2018, In : Digestive and Liver Disease. 50, 10, p. 1068-1075 8 p.

Rutgers, The State University

Research output: Contribution to journalArticle

5 Scopus citations

Intake of stigmasterol and β-sitosterol alters lipid metabolism and alleviates NAFLD in mice fed a high-fat western-style diet

Feng, S., Dai, Z., Liu, A. B., Huang, J., Narsipur, N., Guo, G., Kong, B., Reuhl, K., Lu, W., Luo, Z. & Yang, C. S., Oct 2018, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1863, 10, p. 1274-1284 11 p.

Rutgers, The State University

Research output: Contribution to journalArticle

21 Scopus citations

Liver metabolomics in a mouse model of erythropoietic protoporphyria

Wang, P., Sachar, M., Guo, G. L., Shehu, A. I., Lu, J., Zhong, X. B. & Ma, X., Aug 2018, In : Biochemical Pharmacology. 154, p. 474-481 8 p.

Rutgers, The State University

Research output: Contribution to journalArticle

2 Scopus citations

Metformin action through the microbiome and bile acids

Guo, G. L. & Xie, W., Dec 1 2018, In : Nature medicine. 24, 12, p. 1789-1790 2 p.

Rutgers, The State University

Research output: Contribution to journalComment/debate

2 Scopus citations

Organophosphate Flame-Retardants Alter Adult Mouse Homeostasis and Gene Expression in a Sex-Dependent Manner Potentially Through Interactions With ERα

Krumm, E. A., Patel, V. J., Tillery, T. S., Yasrebi, A., Shen, J., Guo, G. L., Marco, S. M., Buckley, B. T. & Roepke, T. A., Mar 1 2018, In : Toxicological sciences : an official journal of the Society of Toxicology. 162, 1, p. 212-224 13 p.

Rutgers, The State University

Research output: Contribution to journalArticle

14 Scopus citations

Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis

Byun, S., Kim, D. H., Ryerson, D., Kim, Y. C., Sun, H., Kong, B., Yau, P., Guo, G., Eric Xu, H., Kemper, B. & Kemper, J. K., Dec 1 2018, In : Nature communications. 9, 1, 2590.

Rutgers, The State University

Research output: Contribution to journalArticle

10 Scopus citations
2017

Altenusin, a nonsteroidal microbial metabolite, attenuates nonalcoholic fatty liver disease by activating the farnesoid X receptor

Zheng, Z., Zhao, Z., Li, S., Lu, X., Jiang, M., Lin, J., An, Y., Xie, Y., Xu, M., Shen, W., Guo, G. L., Huang, Y., Li, S., Zhang, X. & Xie, W., Oct 2017, In : Molecular pharmacology. 92, 4, p. 425-436 12 p.

Rutgers, The State University

Research output: Contribution to journalArticle

16 Scopus citations

A postprandial FGF19-SHP-LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy

Byun, S., Kim, Y. C., Zhang, Y., Kong, B., Guo, G., Sadoshima, J., Ma, J., Kemper, B. & Kemper, J. K., Jun 14 2017, In : EMBO Journal. 36, 12, p. 1755-1769 15 p.

Rutgers, The State University

Research output: Contribution to journalArticle

21 Scopus citations

Differential regulation of intestinal efflux transporters by pregnancy in mice

Moscovitz, J. E., Yarmush, G., Herrera-Garcia, G., Guo, G. L. & Aleksunes, L. M., 2017, In : Xenobiotica. 47, 11, p. 989-997 9 p.

Rutgers, The State University

Research output: Contribution to journalArticle

5 Scopus citations

Endoplasmic Reticulum Stress Emerges as Novel Regulator for Bile Acid Synthesis

Guo, G., Mar 1 2017, In : CMGH. 3, 2, p. 135 1 p.

Rutgers, The State University

Research output: Contribution to journalEditorial

Farnesoid X receptor ablation sensitizes mice to hepatitis b virus X protein–induced hepatocarcinogenesis

Niu, Y., Xu, M., Slagle, B. L., Huang, H., Li, S., Guo, G. L., Shi, G., Qin, W. & Xie, W., Mar 1 2017, In : Hepatology. 65, 3, p. 893-906 14 p.

Rutgers, The State University

Research output: Contribution to journalArticle

10 Scopus citations

Orally administered berberine modulates hepatic lipid metabolism by altering microbial bile acid metabolism and the intestinal FXR signaling pathway

Sun, R., Yang, N., Kong, B., Cao, B., Feng, D., Yu, X., Ge, C., Huang, J., Shen, J., Wang, P., Feng, S., Fei, F., Guo, J., He, J., Aa, N., Chen, Q., Pan, Y., Schumacher, J. D., Yang, C. S., Guo, G. L. & 2 others, Aa, J. & Wang, G., Feb 2017, In : Molecular pharmacology. 91, 2, p. 110-122 13 p.

Rutgers, The State University

Research output: Contribution to journalArticle

36 Scopus citations

Role of FXR in Liver Inflammation During Nonalcoholic Steatohepatitis

Armstrong, L. E. & Guo, G. L., Apr 1 2017, In : Current Pharmacology Reports. 3, 2, p. 92-100 9 p.

Rutgers, The State University

Research output: Contribution to journalReview article

15 Scopus citations

The effect of fibroblast growth factor 15 deficiency on the development of high fat diet induced non-alcoholic steatohepatitis

Schumacher, J. D., Kong, B., Pan, Y., Zhan, L., Sun, R., Aa, J., Rizzolo, D., Richardson, J. R., Chen, A., Goedken, M., Aleksunes, L. M., Laskin, D. L. & Guo, G. L., Sep 1 2017, In : Toxicology and applied pharmacology. 330, p. 1-8 8 p.

Rutgers, The State University

Research output: Contribution to journalArticle

16 Scopus citations
37 Scopus citations

Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1

Green, A. L., Zhan, L., Eid, A., Zarbl, H., Guo, G. L. & Richardson, J. R., Oct 2017, In : Neuropharmacology. 125, p. 189-196 8 p.

Rutgers, The State University

Research output: Contribution to journalArticle

9 Scopus citations
2016

Dysregulation of bile acid homeostasis in parenteral nutrition mouse model

Zhan, L., Yang, I., Kong, B., Shen, J., Gorczyca, L., Memon, N., Buckley, B. T. & Guo, G. L., 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 310, 2, p. G93-G102

Rutgers, The State University

Research output: Contribution to journalArticle

18 Scopus citations

Fatty liver diseases, bile acids, and FXR

Zhu, Y., Liu, H., Zhang, M. & Guo, G. L., Sep 1 2016, In : Acta Pharmaceutica Sinica B. 6, 5, p. 409-412 4 p.

Rutgers, The State University

Research output: Contribution to journalReview article

40 Scopus citations

Mice with hepatocyte-specific FXR deficiency are resistant to spontaneous but susceptible to cholic acid-induced hepatocarcinogenesis

Kong, B., Zhu, Y., Li, G., Williams, J. A., Buckley, K., Tawfik, O., Luyendyk, J. P. & Guo, G. L., Mar 1 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 310, 5, p. G295-G302

Rutgers, The State University

Research output: Contribution to journalArticle

13 Scopus citations

Regulation of Hepatic Stellate Cells and Fibrogenesis by Fibroblast Growth Factors

Schumacher, J. D. & Guo, G. L., 2016, In : BioMed Research International. 2016, 8323747.

Rutgers, The State University

Research output: Contribution to journalReview article

27 Scopus citations

Restoration of enterohepatic bile acid pathways in pregnant mice following short term activation of Fxr by GW4064

Moscovitz, J. E., Kong, B., Buckley, K., Buckley, B., Guo, G. L. & Aleksunes, L. M., Nov 1 2016, In : Toxicology and applied pharmacology. 310, p. 60-67 8 p.

Rutgers, The State University

Research output: Contribution to journalArticle

16 Scopus citations

Role of farnesoid X receptor in establishment of ontogeny of phase-I drug metabolizing enzyme genes in mouse liver

Peng, L., Piekos, S., Guo, G. L. & Zhong, X. B., Sep 1 2016, In : Acta Pharmaceutica Sinica B. 6, 5, p. 453-459 7 p.

Rutgers, The State University

Research output: Contribution to journalArticle

7 Scopus citations
2015

Chronic activation of FXR in transgenic mice caused perinatal toxicity and sensitized mice to cholesterol toxicity

Cheng, Q., Inaba, Y., Lu, P., Xu, M., He, J., Zhao, Y., Guo, G. L., Kuruba, R., De La Vega, R., Evans, R. W., Li, S. & Xie, W., 2015, In : Molecular Endocrinology. 29, 4, p. 571-582 12 p.

Rutgers, The State University

Research output: Contribution to journalArticle

11 Scopus citations

Editorial

Guo, G. L. & Zhou, H., Jan 1 2015, In : Acta Pharmaceutica Sinica B. 5, 2, 1 p.

Rutgers, The State University

Research output: Contribution to journalEditorial