Huaye Zhang &ndash; Research Output

2019

Loss of Par1b/MARK2 primes microglia during brain development and enhances their sensitivity to injury 11 Medical and Health Sciences 1109 Neurosciences

Dibona, V. L., Zhu, W., Shah, M. K., Rafalia, A., Ben Cheikh, H., Crockett, D. & Zhang, H., Jan 17 2019, In : Journal of Neuroinflammation. 16, 1, 11.

Rutgers, The State University

Research output: Contribution to journal › Article

Microglia

Neurosciences

Health

Wounds and Injuries

Brain

Oxidation of KCNB1 potassium channels in the murine brain during aging is associated with cognitive impairment

Yu, W., Zhang, H., Shin, M. R. & Sesti, F., May 14 2019, In : Biochemical and Biophysical Research Communications. 512, 4, p. 665-669 5 p.

Rutgers, The State University

Research output: Contribution to journal › Article

Potassium Channels

Synapsins

Brain

Oligomerization

Aging of materials

Par3 regulates polarized convergence between APP and BACE1 in hippocampal neurons

Sun, M., Huang, C., Wang, H. & Zhang, H., May 1 2019, In : Neurobiology of Aging. 77, p. 87-93 7 p.

Rutgers, The State University

Research output: Contribution to journal › Article

Amyloid beta-Protein Precursor

Neurons

Amyloid

PDZ Domains

Amyloid Precursor Protein Secretases

2018

Introduction to the special issue on membrane trafficking in neurons

Zhang, H., Winckler, B. & Cai, Q., Mar 1 2018, In : Developmental Neurobiology. 78, 3, p. 167-169 3 p.

Rutgers, The State University

Research output: Contribution to journal › Editorial

6 Citations (Scopus)

Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains

Zhang, L., Zhang, P., Wang, G., Zhang, H., Zhang, Y., Yu, Y., Zhang, M., Xiao, J., Crespo, P., Hell, J. W., Lin, L., Huganir, R. L. & Zhu, J. J., May 16 2018, In : Neuron. 98, 4, p. 783-800.e4

Rutgers, The State University

Research output: Contribution to journal › Article

Neuronal Plasticity

Lysosomes

Endoplasmic Reticulum

Long-Term Synaptic Depression

Lipids

4 Citations (Scopus)

The endolysosomal system and proteostasis: From development to degeneration

Winckler, B., Faundez, V., Maday, S., Cai, Q., Almeida, C. G. & Zhang, H., Oct 31 2018, In : Journal of Neuroscience. 38, 44, p. 9364-9374 11 p.

Rutgers, The State University

Research output: Contribution to journal › Article

Autophagy

Neurons

Neurodegenerative Diseases

Cell Biology

Maintenance

4 Citations (Scopus)

The GluN2A Subunit Regulates Neuronal NMDA receptor-Induced Microglia-Neuron Physical Interactions

Eyo, U. B., Bispo, A., Liu, J., Sabu, S., Wu, R., Dibona, V. L., Zheng, J., Murugan, M., Zhang, H., Tang, Y. & Wu, L-J., Dec 1 2018, In : Scientific reports. 8, 1, 828.

Rutgers, The State University

Research output: Contribution to journal › Article

Microglia

N-Methyl-D-Aspartate Receptors

Neurons

Physical Phenomena

Photons

2017

7 Citations (Scopus)

BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method

Lim, C. S., Kang, X., Mirabella, V., Zhang, H., Bu, Q., Araki, Y., Hoang, E. T., Wang, S., Shen, Y., Choi, S., Kaang, B. K., Chang, Q., Pang, Z., Huganir, R. L. & Zhu, J. J., Mar 15 2017, In : Genes & development. 31, 6, p. 537-552 16 p.

Rutgers, The State University

Research output: Contribution to journal › Article

Lentivirus

Mutation

Precision Medicine

Genes

Neurons

5 Citations (Scopus)

Par3 and aPKC regulate BACE1 endosome-to-TGN trafficking through PACS1

Sun, M. & Zhang, H., Dec 1 2017, In : Neurobiology of Aging. 60, p. 129-140 12 p.

Rutgers, The State University

Research output: Contribution to journal › Article

trans-Golgi Network

Endosomes

Enzymes

Alzheimer Disease

Amyloid beta-Protein Precursor

1 Citation (Scopus)

Piconewton-Scale Analysis of Ras-BRaf Signal Transduction with Single-Molecule Force Spectroscopy

Lim, C. S., Wen, C., Sheng, Y., Wang, G., Zhou, Z., Wang, S., Zhang, H., Ye, A. & Zhu, J. J., Oct 25 2017, In : Small. 13, 40, 1701972.

Rutgers, The State University

Research output: Contribution to journal › Article

Signal transduction

Signal Transduction

Spectroscopy

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid

Molecules

9 Citations (Scopus)

Postsynaptic density 95 (PSD-95) serine 561 phosphorylation regulates a conformational switch and bidirectional dendritic spine structural plasticity

Wu, Q., Sun, M., Bernard, L. P. & Zhang, H., Jan 1 2017, In : Journal of Biological Chemistry. 292, 39, p. 16150-16160 11 p.

Rutgers, The State University

Research output: Contribution to journal › Article

Post-Synaptic Density

Dendritic Spines

Phosphorylation

Serine

Plasticity

2016

2 Citations (Scopus)

Polarity determinants in dendritic spine development and plasticity

Zhang, H., Jan 1 2016, In : Neural Plasticity. 2016, 3145019.

Rutgers, The State University

Research output: Contribution to journal › Review article

Dendritic Spines

Proteins

Spine

Cell Polarity

Morphogenesis

10 Citations (Scopus)

The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb

Sun, M., Asghar, S. Z. & Zhang, H., Sep 1 2016, In : Neurobiology of Disease. 93, p. 1-11 11 p.

Rutgers, The State University

Research output: Contribution to journal › Article

Amyloid beta-Protein Precursor

Protein Transport

Amyloid

Proteins

Alzheimer Disease

2015

2 Citations (Scopus)

Dendritic spine morphology and dynamics in health and disease

Lee, S., Zhang, H. & Webb, D. J., Jun 3 2015, In : Cell Health and Cytoskeleton. 7, p. 121-131 11 p.

Rutgers, The State University

Research output: Contribution to journal › Review article

Dendritic Spines

Spine

Health

Defects

Plasticity

14 Citations (Scopus)

MARK/Par1 kinase is activated downstream of NMDA receptors through a PKA-dependent mechanism

Bernard, L. P. & Zhang, H., May 1 2015, In : PLoS ONE. 10, 5, e0124816.

Rutgers, The State University

Research output: Contribution to journal › Article

cAMP-dependent protein kinase

Cyclic AMP-Dependent Protein Kinases

N-Methyl-D-Aspartate Receptors

Microtubules

microtubules

2013

14 Citations (Scopus)

Calcium phosphate transfection of primary hippocampal neurons.

Sun, M., Bernard, L. P., Dibona, V. L., Wu, Q. & Zhang, H., Jan 1 2013, In : Journal of visualized experiments : JoVE. 81

Rutgers, The State University

Research output: Contribution to journal › Article

Calcium phosphate

Neurons

Transfection

Cultured Cells

Cells

71 Citations (Scopus)

The RNA-binding protein Fus directs translation of localized mrnas in APC-RNP granules

Yasuda, K., Zhang, H., Loiselle, D., Haystead, T., Macara, I. G. & Mili, S., Dec 9 2013, In : Journal of Cell Biology. 203, 5, p. 737-746 10 p.

Rutgers, The State University

Research output: Contribution to journal › Article

Adenomatous Polyposis Coli

RNA-Binding Proteins

Amyotrophic Lateral Sclerosis

RNA

Physiological Phenomena

2012

16 Citations (Scopus)

The polarity protein partitioning-defective 1 (PAR-1) regulates dendritic spine morphogenesis through phosphorylating postsynaptic density protein 95 (PSD-95)

Wu, Q., DiBona, V. L., Bernard, L. P. & Zhang, H., Aug 31 2012, In : Journal of Biological Chemistry. 287, 36, p. 30781-30788 8 p.

Rutgers, The State University

Research output: Contribution to journal › Article

Dendritic Spines

Morphogenesis

Neurons

Phosphorylation

Proteins

2011

33 Citations (Scopus)

The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons

Kim, J. Y., Oh, M. H., Bernard, L. P., Macara, I. G. & Zhang, H., Oct 28 2011, In : Journal of Biological Chemistry. 286, 43, p. 37615-37624 10 p.

Rutgers, The State University

Research output: Contribution to journal › Article

Rho Guanine Nucleotide Exchange Factors

Morphogenesis

Neurons

Spine

Plasticity

2009

Rho GTPases and Spines

Zhang, H., Jan 1 2009, Encyclopedia of Neuroscience. Elsevier Ltd, p. 357-364 8 p.

Rutgers, The State University

Research output: Chapter in Book/Report/Conference proceeding › Chapter

rho GTP-Binding Proteins

Actins

Spine

Dendritic Spines

Morphogenesis

2008

105 Citations (Scopus)

The PAR-6 Polarity Protein Regulates Dendritic Spine Morphogenesis through p190 RhoGAP and the Rho GTPase

Zhang, H. & Macara, I. G., Feb 12 2008, In : Developmental cell. 14, 2, p. 216-226 11 p.

Research output: Contribution to journal › Article

rho GTP-Binding Proteins

Dendritic Spines

Morphogenesis

Spine

Proteins

2007

56 Citations (Scopus)

α5 integrin signaling regulates the formation of spines and synapses in hippocampal neurons

Webb, D. J., Zhang, H., Majumdar, D. & Horwitz, A. F., Mar 2 2007, In : Journal of Biological Chemistry. 282, 10, p. 6929-6935 7 p.

Research output: Contribution to journal › Article

Integrins

Synapses

Neurons

Dendritic Spines

Spine

2006

152 Citations (Scopus)

The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesis

Zhang, H. & Macara, I. G., Mar 1 2006, In : Nature Cell Biology. 8, 3, p. 227-237 11 p.

Research output: Contribution to journal › Article

Dendritic Spines

Morphogenesis

Pseudopodia

Spine

Genes

2005

239 Citations (Scopus)

A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC

Zhang, H., Webb, D. J., Asmussen, H., Niu, S. & Horwitz, A. F., Mar 30 2005, In : Journal of Neuroscience. 25, 13, p. 3379-3388 10 p.

Research output: Contribution to journal › Article

Morphogenesis

Synapses

Spine

Phosphotransferases

Dendritic Spines

31 Citations (Scopus)

Cell migration: an overview.

Webb, D. J., Zhang, H. & Horwitz, A. F., Jan 1 2005, In : Methods in molecular biology (Clifton, N.J.). 294, p. 3-11 9 p.

Research output: Contribution to journal › Review article

Cell Movement

Homeostasis

Pathology

Technology

2003

143 Citations (Scopus)

Synapse formation is regulated by the signaling adaptor GIT1

Zhang, H., Webb, D. J., Asmussen, H. & Horwitz, A. F., Apr 14 2003, In : Journal of Cell Biology. 161, 1, p. 131-142 12 p.

Research output: Contribution to journal › Article

Synapses

Actins

Spine

G-Protein-Coupled Receptor Kinases

Receptor-Interacting Protein Serine-Threonine Kinases

2001

142 Citations (Scopus)

The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL)

West, K. A., Zhang, H., Brown, M. L. C., Nikolopoulos, S. N., Riedy, M. C., Horwitz, A. F. & Turner, C. E., Jul 9 2001, In : Journal of Cell Biology. 154, 1, p. 161-176 16 p.

Rutgers, The State University

Research output: Contribution to journal › Article

Paxillin

Cell Movement

Phosphotransferases

Focal Adhesion Protein-Tyrosine Kinases

Actin Cytoskeleton