• 1824 Citations
  • 20 h-Index
20022020

Research output per year

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Personal profile

Research interests

Research Expertise: 
Neurodegeneration | Mouse Genetics | Neuroinflammation

My primary research focus is on the role of inflammation in neurodegenerative diseases such as Niemann Pick Type-C disease. In particular, emerging evidence suggests that neuroinflammation, a carefully controlled infiltration of specific immune cells into the tissue, may be critical for neuronal damage. The interplay between neurons, resident support, endothelial cell and infiltrating immune cells (particularly monocytes) is complex. Therefore I will apply cellular and genetic approaches to critically assess the role of the different cell types in neurodegenerative diseases.

Honors and Awards:
The Jackson Laboratory Postdoctoral Fellowship, NIH T32 training grant, 2009-2011

Member of:
Society for Neuroscience (SFN.org)
American Society for Cell Biology (ASCB)

Education/Academic qualification

Doctor of Philosophy, doctorate

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Research Output

  • 1824 Citations
  • 20 h-Index
  • 31 Article
  • 2 Review article

Deficiency of complement component c1q prevents cerebrovascular damage and white matter loss in a mouse model of chronic obesity

Graham, L. C., Kocalis, H. E., Soto, I. & Howell, G. R., May 1 2020, In : eNeuro. 7, 3, p. 1-12 12 p., ENEURO.0057-20.2020.

Rowan University

Research output: Contribution to journalArticle

Open Access
  • NPC1 deficiency impairs cerebellar postnatal development of microglia and climbing fiber refinement in a mouse model of Niemann-Pick disease type C

    Boyle, B. R., Melli, S. E., Altreche, R. S., Padron, Z. M., Yousufzai, F. A. K., Kim, S., Vasquez, M. D., Carone, D. M., Carone, B. R. & Soto, I., Aug 3 2020, In : Development (Cambridge). 147, 21

    Rowan University

    Research output: Contribution to journalArticle

    Open Access
  • Enhancing face validity of mouse models of Alzheimer’s disease with natural genetic variation

    Onos, K. D., Uyar, A., Keezer, K. J., Jackson, H. M., Preuss, C., Acklin, C. J., O’Rourke, R., Buchanan, R., Cossette, T. L., Sukoff Rizzo, S. J., Soto, I., Carter, G. W. & Howell, G. R., May 2019, In : PLoS genetics. 15, 5, e1008155.

    Rowan University

    Research output: Contribution to journalArticle

    Open Access
  • 8 Scopus citations

    Increased interactions and engulfment of dendrites by microglia precede Purkinje cell degeneration in a mouse model of Niemann Pick Type-C

    Kavetsky, L., Green, K. K., Boyle, B. R., Yousufzai, F. A. K., Padron, Z. M., Melli, S. E., Kuhnel, V. L., Jackson, H. M., Blanco, R. E., Howell, G. R. & Soto, I., Dec 1 2019, In : Scientific reports. 9, 1, 14722.

    Rowan University

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Meox2 haploinsufficiency accelerates axonal degeneration in DBA/2J glaucoma

    Buchanan, R. A., Foley, K. E., Pepper, K. W., Reagan, A. M., Keezer, K. J., Hewes, A. A., Diemler, C. A., Preuss, C., Soto, I., John, S. W. M. & Howell, G. R., Aug 2019, In : Investigative Ophthalmology and Visual Science. 60, 10, p. 3283-3296 14 p.

    Rowan University

    Research output: Contribution to journalArticle

    Open Access
  • Press / Media

    Aerobics can keep Alzheimer’s at bay

    Ileana Soto Reyes

    10/30/1510/31/15

    3 items of Media coverage

    Rowan University

    Press/Media: Press / Media

    Aerobics can keep Alzheimer's at bay

    Ileana Soto Reyes

    10/30/15

    5 items of Media coverage

    Rowan University

    Press/Media: Press / Media