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Dr. John Siekierka's research interests deal with the biochemistry and molecular biology of parasite anti-oxidative stress responses. His group has been studying protein kinase signaling pathways important for parasite defense against host immune responses in the parasitic nematode, Brugia malayi, and the protozoal parasite, Leishmania mexicana. They have identified selective inhibitors of these protein kinases which may have therapeutic potential.
Scholarly Interests
Biochemistry of protein kinase signaling pathways. Protein kinase screening assays and drug development. Biochemistry of parasitic anti-stress responses.
Research interests
Research interests deal with the biochemistry and molecular biology of parasite anti-oxidative stress responses.
Faculty/Media Expert
Expert on biochemistry and molecular biology of parasites.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Increasing Access to Graduate Degrees, Professional Development, and Research Experiences: Pathways to Achievement in Chemical Industries
Goodey, N. (CoPI), Siekierka, J. (CoPI), O'Neil, G. (PI) & Rotella, D. (CoPI)
1/1/21 → 12/31/25
Project: Research
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Development of inhibitors of P. falciparum cGMP dependent protein kinase (PfPKG) for malaria chemoprevention
Bhanot, P. (PI), Rotella, D. (CoPI) & Siekierka, J. (CoPI)
National Institute of Allergy and Infectious Diseases
8/1/17 → 7/31/21
Project: Research project
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Opening Pathways, Engaging, and Networking in Chemistry in Northern New Jersey (OPEN-NJ)
Goodey, N. (PI), Herbert, K. (CoPI), Krumins, J. (CoPI) & Siekierka, J. (CoPI)
7/1/15 → 6/30/21
Project: Research project
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Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials
Gilleran, J. A., Ashraf, K., Delvillar, M., Eck, T., Fondekar, R., Miller, E. B., Hutchinson, A., Dong, A., Seitova, A., De Souza, M. L., Augeri, D., Halabelian, L., Siekierka, J., Rotella, D. P., Gordon, J., Childers, W. E., Grier, M. C., Staker, B. L., Roberge, J. Y. & Bhanot, P., Mar 14 2024, In: Journal of medicinal chemistry. 67, 5, p. 3467-3503 37 p.Rutgers, The State University, Montclair State University
Research output: Contribution to journal › Article › peer-review
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A novel series of putative Brugia malayi histone demethylase inhibitors as potential anti-filarial drugs
Kreiss, T., Eck, T., Hart, B., Tummalapalli, S., Rotella, D. & Siekierka, J., 2022, In: PLoS neglected tropical diseases. 16, 3, e0010216.Research output: Contribution to journal › Article › peer-review
Open Access -
Characterization of Competitive Inhibitors of Plasmodium falciparum cGMP-Dependent Protein Kinase**
Eck, T., Laureano de Souza, M., Delvillar, M., Ashraf, K., Yadav Bheemanaboina, R. R., Chakrasali, R., Kreiss, T., Siekierka, J. J., Rotella, D. P., Bhanot, P. & Goodey, N. M., Apr 5 2022, In: ChemBioChem. 23, 7, e202100704.Montclair State University, Rutgers, The State University
Research output: Contribution to journal › Article › peer-review
Open Access -
Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization
Hawryluk, N., Zhiru, L., Carlow, C., Gokool, S., Townson, S., Kreiss, T., Chojnowski, A., Prorok, M., Siekierka, J., Ehrens, A., Koschel, M., Lhermitte-Vallarino, N., Martin, C., Hoerauf, A., Hernandez, G., Canan, S., Khetani, V., Zeldis, J., Specht, S. & Hübner, M. P. & 1 others, , Aug 2022, In: International Journal for Parasitology: Drugs and Drug Resistance. 19, p. 89-97 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Discovery of Imidazole-Based Inhibitors of Plasmodium falciparum cGMP-Dependent Protein Kinase
Bheemanaboina, R. R. Y., De Souza, M. L., Gonzalez, M. L., Mahmood, S. U., Eck, T., Kreiss, T., Aylor, S. O., Roth, A., Lee, P., Pybus, B. S., Colussi, D. J., Childers, W. E., Gordon, J., Siekierka, J. J., Bhanot, P. & Rotella, D. P., Dec 9 2021, In: ACS Medicinal Chemistry Letters. 12, 12, p. 1962-1967 6 p.Rutgers, The State University, Montclair State University
Research output: Contribution to journal › Article › peer-review
Open Access