• 5086 Citations
  • 34 h-Index
1973 …2018

Research output per year

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Research Output

2016

Expression, purification and enzymatic characterization of Brugia malayi dihydrofolate reductase

Perez-Abraham, R., Sanchez, K. G., Alfonso, M., Gubler, U., Siekierka, J. J. & Goodey, N. M., Dec 1 2016, In : Protein Expression and Purification. 128, p. 81-85 5 p.

Montclair State University

Research output: Contribution to journalArticle

1 Scopus citations
2011

Human p38 mitogen-activated protein kinase inhibitor drugs inhibit Plasmodium falciparum replication

Brumlik, M. J., Nkhoma, S., Kious, M. J., Thompson, G. R., Patterson, T. F., Siekierka, J. J., Anderson, T. J. C. & Curiel, T. J., Jun 1 2011, In : Experimental Parasitology. 128, 2, p. 170-175 6 p.

Montclair State University

Research output: Contribution to journalArticle

15 Scopus citations

The role of a Brugia malayi p38 MAP kinase ortholog (Bm-MPK1) in parasite anti-oxidative stress responses

Patel, A., Chojnowski, A. N., Gaskill, K., De Martini, W., Goldberg, R. L. & Siekierka, J. J., Apr 1 2011, In : Molecular and Biochemical Parasitology. 176, 2, p. 90-97 8 p.

Montclair State University

Research output: Contribution to journalArticle

11 Scopus citations
2010
15 Scopus citations
2006

Effects of drug combinations on smooth muscle cell proliferation: An isobolographic analysis

Parry, T. J., Thyagarajan, R., Argentieri, D., Falotico, R., Siekierka, J. & Tallarida, R. J., Feb 17 2006, In : European Journal of Pharmacology. 532, 1-2, p. 38-43 6 p.

Montclair State University

Research output: Contribution to journalArticle

6 Scopus citations

Inhibitors of unactivated p38 MAP kinase

Bullington, J., Argentieri, D., Averill, K., Carter, D., Cavender, D., Fahmy, B., Fan, X., Hall, D., Heintzelman, G., Jackson, P., Leung, W. P., Li, X., Ling, P., Olini, G., Razler, T., Reuman, M., Rupert, K., Russell, R., Siekierka, J., Wadsworth, S. & 3 others, Wolff, R., Xiang, B. & Zhang, Y. M., Dec 1 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 23, p. 6102-6106 5 p.

Montclair State University

Research output: Contribution to journalArticle

7 Scopus citations
2005

Drug-eluting stents: Sirolimus and paclitaxel differentially affect cultured cells and injured arteries

Parry, T. J., Brosius, R., Thyagarajan, R., Carter, D., Argentieri, D., Falotico, R. & Siekierka, J., Nov 7 2005, In : European Journal of Pharmacology. 524, 1-3, p. 19-29 11 p.

Montclair State University

Research output: Contribution to journalArticle

99 Scopus citations

HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation

Muthumani, K., Choo, A. Y., Hwang, D. S., Premkumar, A., Dayes, N. S., Harris, C., Green, D. R., Wadsworth, S. A., Siekierka, J. J. & Weiner, D. B., Sep 15 2005, In : Blood. 106, 6, p. 2059-2068 10 p.

Montclair State University

Research output: Contribution to journalArticle

39 Scopus citations
2004

Suppression of HIV-1 viral replication and cellular pathogenesis by a novel p38/JNK kinase inhibitor

Muthumani, K., Wadsworth, S. A., Dayes, N. S., Hwang, D. S., Choo, A. Y., Abeysinghe, H. R., Siekierka, J. & Weiner, D. B., Mar 26 2004, In : AIDS. 18, 5, p. 739-748 10 p.

Montclair State University

Research output: Contribution to journalArticle

31 Scopus citations
2003
197 Scopus citations
2002

Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells

Tao, L., Wadsworth, S., Mercer, J., Mueller, C., Lynn, K., Siekierka, J. & August, A., Apr 1 2002, In : Biochemical Journal. 363, 1, p. 175-182 8 p.

Montclair State University

Research output: Contribution to journalArticle

20 Scopus citations
2001
46 Scopus citations
1999

Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice

Kanakaraj, P., Ngo, K., Wu, Y., Angulo, A., Ghazal, P., Harris, C. A., Siekierka, J. J., Peterson, P. A. & Fung-Leung, W. P., Apr 5 1999, In : Journal of Experimental Medicine. 189, 7, p. 1129-1138 10 p.

Montclair State University

Research output: Contribution to journalArticle

137 Scopus citations
84 Scopus citations

RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase

Wadsworth, S. A., Cavender, D. E., Beers, S. A., Lalan, P., Schafer, P. H., Malloy, E. A., Wu, W., Fahmy, B., Olini, G. C., Davis, J. E., Pellegrino-Gensey, J. L., Wachter, M. P. & Siekierka, J. J., Nov 1 1999, In : Journal of Pharmacology and Experimental Therapeutics. 291, 2, p. 680-687 8 p.

Montclair State University

Research output: Contribution to journalArticle

148 Scopus citations
64 Scopus citations
1998

6-amino-2-(4-fluorophenyl)-4-methoxy-3-(4-pyridyl)-1H-pyrrolo[2,3- b]pyridine (RWJ 68354): A potent and selective p38 kinase inhibitor [4]

Henry, J. R., Rupert, K. C., Dodd, J. H., Turchi, I. J., Wadsworth, S. A., Cavender, D. E., Fahmy, B., Olini, G. C., Davis, J. E., Lee Pellegrino-Gensey, J., Schafer, P. H. & Siekierka, J., Oct 23 1998, In : Journal of medicinal chemistry. 41, 22, p. 4196-4198 3 p.

Montclair State University

Research output: Contribution to journalLetter

75 Scopus citations

Detergent-salt resistance of LAP2α in interphase nuclei and phosphorylation-dependent association with chromosomes early in nuclear assembly implies functions in nuclear structure dynamics

Dechat, T., Gotzmann, J., Stockinger, A., Harris, C. A., Talle, M. A., Siekierka, J. J. & Foisner, R., Aug 17 1998, In : EMBO Journal. 17, 16, p. 4887-4902 16 p.

Montclair State University

Research output: Contribution to journalArticle

115 Scopus citations

Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production

Kanakaraj, P., Schafer, P. H., Cavender, D. E., Wu, Y., Ngo, K., Grealish, P. F., Wadsworth, S. A., Peterson, P. A., Siekierka, J. J., Harris, C. A. & Fung-Leung, W. P., Jun 15 1998, In : Journal of Experimental Medicine. 187, 12, p. 2073-2079 7 p.

Montclair State University

Research output: Contribution to journalArticle

170 Scopus citations

Potent inhibitors of the MAP kinase p38

Henry, J. R., Rupert, K. C., Dodd, J. H., Turchi, I. J., Wadsworth, S. A., Cavender, D. E., Schafer, P. H. & Siekierka, J., Dec 1 1998, In : Bioorganic and Medicinal Chemistry Letters. 8, 23, p. 3335-3340 6 p.

Montclair State University

Research output: Contribution to journalArticle

45 Scopus citations

The development of novel and selective p56(lck) tyrosine kinase inhibitors

Bullington, J. L., Cameron, J. C., Davis, J. E., Dodd, J. H., Harris, C. A., Henry, J. R., Pellegrino-Gensey, J. L., Rupert, K. C. & Siekierka, J. J., Sep 22 1998, In : Bioorganic and Medicinal Chemistry Letters. 8, 18, p. 2489-2494 6 p.

Montclair State University

Research output: Contribution to journalArticle

17 Scopus citations

Yeast immunophilins: Purification and assay of yeast FKBP12

Wiederrecht, G. & Siekierka, J., Jan 1 1998, In : Methods in enzymology. 290, p. 74-84 11 p.

Montclair State University

Research output: Contribution to journalArticle

1997

T cell activation signals upregulate p38 map k1nase activity

Wang, L., Schäfer, P. H., Davis, J. K., Wads Worth, S. A. & Siekierka, J. J., Dec 1 1997, In : FASEB Journal. 11, 9, p. A1167

Montclair State University

Research output: Contribution to journalArticle

1996

Editorial

Siekierka, J., Apr 1 1996, In : Methods. 9, 2, 1 p.

Montclair State University

Research output: Contribution to journalEditorial

1 Scopus citations
1995

Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO β to rat lamin-associated polypeptide 2

Harris, C. A., Andryuk, P. J., Cline, S. W., Mathew, S., Siekierka, J. J. & Goldstein, G., Jul 20 1995, In : Genomics. 28, 2, p. 198-205 8 p.

Montclair State University

Research output: Contribution to journalArticle

71 Scopus citations
1994
8 Scopus citations

Three distinct human thymopoietins are derived from alternatively spliced mRNAs

Harris, C. A., Andryuk, P. J., Cline, S., Karen Chan, H., Natarajan, A., Siekierka, J. J. & Goldstein, G., Jul 5 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 14, p. 6283-6287 5 p.

Montclair State University

Research output: Contribution to journalArticle

98 Scopus citations
1993

Rapamycin-induced inhibition of p34(cdc2) kinase activation is associated with G1/S-phase growth arrest in T lymphocytes

Morice, W. G., Brunn, G. J., Wiederrecht, G., Siekierka, J. J. & Abraham, R. T., Jan 1 1993, In : Journal of Biological Chemistry. 268, 5, p. 3734-3738 5 p.

Montclair State University

Research output: Contribution to journalArticle

162 Scopus citations

Rapamycin inhibition of interleukin-2-dependent p33(cdk2) and p34(cdc2) kinase activation in T lymphocytes

Morice, W. G., Wiederrecht, G., Brunn, G. J., Siekierka, J. J. & Abraham, R. T., Jan 1 1993, In : Journal of Biological Chemistry. 268, 30, p. 22737-22745 9 p.

Montclair State University

Research output: Contribution to journalArticle

130 Scopus citations
1992

Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506-binding protein as well as a protein complex

Wiederrecht, G., Hung, S., Chan, H. K., Marcy, A., Martin, M., Calaycay, J., Boulton, D., Sigal, N., Kincaid, R. L. & Siekierka, J. J., Nov 11 1992, In : Journal of Biological Chemistry. 267, 30, p. 21753-21760 8 p.

Montclair State University

Research output: Contribution to journalArticle

89 Scopus citations

FK-506 and cyclosporin A: immunosuppressive mechanism of action and beyond

Siekierka, J. J. & Sigal, N. H., 1992, In : Current Opinion in Immunology. 4, 5, p. 548-552 5 p.

Montclair State University

Research output: Contribution to journalArticle

73 Scopus citations

Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin binding protein

Wiederrecht, G., Martin, M. M., Sigal, N. H. & Siekierka, J. J., May 29 1992, In : Biochemical and Biophysical Research Communications. 185, 1, p. 298-303 6 p.

Montclair State University

Research output: Contribution to journalArticle

20 Scopus citations

The immunosuppressive and toxic effects of FK-506 are mechanistically related: Pharmacology of a novel antagonist of FK-506 and rapamycin

Dumont, F. J., Staruch, M. J., Koprak, S. L., Siekierka, J. J., Lin, C. S., Harrison, R., Sewell, T., Kindt, V. M., Beattie, T. R., Wyvratt, M. & Sigal, N. H., Sep 1 1992, In : Journal of Experimental Medicine. 176, 3, p. 751-760 10 p.

Montclair State University

Research output: Contribution to journalArticle

221 Scopus citations

FK-506 and cyclosporin A inhibit highly similar signal transduction pathways in human T lymphocytes

Lin, C. S., Boltz, R. C., Siekierka, J. J. & Sigal, N. H., Apr 1 1991, In : Cellular Immunology. 133, 2, p. 269-284 16 p.

Montclair State University

Research output: Contribution to journalArticle

106 Scopus citations
76 Scopus citations

FKBP, the binding protein for the immunosuppressive drug, FK-506, is not an inhibitor of protein kinase C activity

Cryan, J., Hung, S. H. Y., Wiederrecht, G., Sigal, N. H. & Siekierka, J. J., Oct 31 1991, In : Biochemical and Biophysical Research Communications. 180, 2, p. 846-852 7 p.

Montclair State University

Research output: Contribution to journalArticle

9 Scopus citations

Inhibition of human T-cell activation by FK 506, rapamycin, and cyclosporine A

Sigal, N. H., Lin, C. S. & Siekierka, J. J., May 17 1991, In : Transplantation Proceedings. 23, 2 SUPPL. 2, p. 1-5 5 p.

Montclair State University

Research output: Contribution to journalArticle

57 Scopus citations

Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?

Sigal, N. H., Dumont, F., Durette, P., Siekierka, J. J., Peterson, L., Rich, D. H., Dunlap, B. E., Staruch, M. J., Melino, M. R., Koprak, S. L., Williams, D., Witzel, B. & Pisano, J. M., Jan 1 1991, In : Journal of Experimental Medicine. 173, 3, p. 619-628 10 p.

Montclair State University

Research output: Contribution to journalArticle

217 Scopus citations

Is FKBP involved in the immunosuppressive and/or toxic mechanism of action of FK 506?

Sigal, N. H., Dumont, F. J., Siekierka, J., Wiederrecht, G., Parent, S. A. & Brizuela, L., Dec 1 1991, In : Transplantation Proceedings. 23, 6, p. 2846-2849 4 p.

Montclair State University

Research output: Contribution to journalArticle

14 Scopus citations

Potential roles of other FK 506-binding proteins in mediating the effects of FK 506

Siekierka, J. J., Wiederrecht, G., Cryan, J., Hung, S. H. Y., Comisky, M. & Sigal, N. H., Dec 1 1991, In : Transplantation Proceedings. 23, 6, p. 2720-2721 2 p.

Montclair State University

Research output: Contribution to journalArticle

7 Scopus citations
1990

Observations on the mechanism of action of FK-506. A pharmacologic probe of lymphocyte signal transduction

Sigal, N. H., Siekierka, J. J. & Dumont, F. J., Nov 15 1990, In : Biochemical Pharmacology. 40, 10, p. 2201-2208 8 p.

Montclair State University

Research output: Contribution to journalArticle

25 Scopus citations