Mary Alpaugh

Associate Professor

    • 1418 Citations
    • 17 h-Index
    19942019
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    Personal profile

    Research interests

    Research Expertise:
    Cancer Biology | Tumor Progression | Metastasis | Intravasation

    My research focuses predominantly on the molecular mechanisms of intravasation, the rate-limiting step of metastasis, and resistance/susceptibility of lymphovascular emboli to therapeutics.

    Metastasis poses the single most difficult clinical challenge in the attempt to manage and treat cancer. In this effort, I have established patient-derived xenografts, signifcantly the first (and only) human transplantable inflammatory breast cancer xenograft, called MARY-X. Inflammatory breast cancer (IBC) is one of the most aggressive types of breast cancer; nearly 100% of all women with IBC have lymph node involvement and 25% have distant metastases upon diagnosis. The signature phenotype of IBC is florid lymphovascular invasion of cancer emboli. Whereas most human xenografts grow as a subcutaneous confluent cellular mass, MARY-X grows exclusively in the murine lymphatic and blood vessels, recapitulating the phenotype displayed in human IBC and in essence providing both a preclinical IBC model and a relevant model of metastasis. MARY-X, in vitro, is a primary cellular derivative from tumor explants. These tumor cells spontaneously form tight, compact aggregates of cells termed “MARY-X spheroids”. Comparable to human IBC emboli, a persistent, over-expression of an intact E-cadherin/α, β-catenin axis mediates the compaction of both in vitro and in vivo MARY-X spheroids and tumor emboli, respectively. The in vitro MARY-X spheroid has comparative 3-dimensional (3-D) architectural/pathophysiological features to the lymphovascular embolus. Therefore MARY-X provides a relevant 3D in vitro analysis platform for drug design and development of IBC and metastatic disease i.e. the lymphovascular embolus.

    Member of:
    American Association for Cancer Research

    Education/Academic qualification

    University of Houston

    Fingerprint Dive into the research topics where Mary Alpaugh is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

    • 1 Similar Profiles
    Inflammatory Breast Neoplasms Medicine & Life Sciences
    Embolism Medicine & Life Sciences
    Cadherins Medicine & Life Sciences
    Neoplasms Medicine & Life Sciences
    Breast Neoplasms Medicine & Life Sciences
    Heterografts Medicine & Life Sciences
    Neoplasm Metastasis Medicine & Life Sciences
    Phenotype Medicine & Life Sciences

    Network Recent external collaboration on country level. Dive into details by clicking on the dots.

    Projects 2016 2018

    Research Output 1994 2019

    • 1418 Citations
    • 17 h-Index
    • 28 Article
    • 1 Comment/debate
    • 1 Letter
    • 1 Review article

    Chiral resolution of a caged xanthone and evaluation across a broad spectrum of breast cancer subtypes

    Chantarasriwong, O., Dorwart, T. J., Morales, T. H., Maggio, S. F., Settle, A. L., Milcarek, A. T., Alpaugh, M. L., Theodoraki, M. A. & Theodorakis, E. A., Dec 2019, In : Bioorganic Chemistry. 93, 103303.

    Rowan University

    Research output: Contribution to journalArticle

    Enantiomers
    Cells
    Xanthones
    Breast Neoplasms
    Cytotoxicity

    Reply to ‘H-STS, L-STS and KRJ-I are not authentic GEPNET cell lines’

    Alvarez, M. J., Yan, P., Alpaugh, M. L., Bowden, M., Sicinska, E., Zhou, C. W., Karan, C., Realubit, R. B., Mundi, P. S., Grunn, A., Jäger, D., Chabot, J. A., Fojo, A. T., Oberstein, P. E., Hibshoosh, H., Milsom, J. W., Kulke, M. H., Loda, M., Chiosis, G., Reidy-Lagunes, D. L. & 1 others, Califano, A., Oct 1 2019, In : Nature genetics. 51, 10, p. 1427-1428 2 p.

    Rowan University

    Research output: Contribution to journalLetter

    2 Citations (Scopus)

    Synthesis, structure-activity relationship and in vitro pharmacodynamics of A-ring modified caged xanthones in a preclinical model of inflammatory breast cancer

    Chantarasriwong, O., Milcarek, A. T., Morales, T. H., Settle, A. L., Rezende, C. O., Althufairi, B. D., Theodoraki, M. A., Alpaugh, M. & Theodorakis, E. A., Apr 15 2019, In : European Journal of Medicinal Chemistry. 168, p. 405-413 9 p.

    Rowan University

    Research output: Contribution to journalArticle

    Inflammatory Breast Neoplasms
    Xanthones
    Pharmacodynamics
    Structure-Activity Relationship
    Cytotoxicity
    1 Citation (Scopus)

    HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons

    Kishinevsky, S., Wang, T., Rodina, A., Chung, S. Y., Xu, C., Philip, J., Taldone, T., Joshi, S., Alpaugh, M., Bolaender, A., Gutbier, S., Sandhu, D., Fattahi, F., Zimmer, B., Shah, S. K., Chang, E., Inda, C., Koren, J., Saurat, N. G., Leist, M. & 9 others, Gross, S. S., Seshan, V. E., Klein, C., Tomishima, M. J., Erdjument-Bromage, H., Neubert, T. A., Henrickson, R. C., Chiosis, G. & Studer, L., Dec 1 2018, In : Nature communications. 9, 1, 4345.

    Rowan University

    Research output: Contribution to journalArticle

    Dopaminergic Neurons
    Biosensing Techniques
    Mesencephalon
    Parkinson Disease
    Pluripotent Stem Cells
    1 Citation (Scopus)

    Erratum: HDAC6 activity is a non-oncogene addiction hub for inflammatory breast cancers[Breast Cancer Res,17 (2015)(149)] DOI:10.1186/s13058-015-0658-0

    Putcha, P., Yu, J., Rodriguez-Barrueco, R., Saucedo-Cuevas, L., Villagrasa, P., Murga-Penas, E., Quayle, S. N., Yang, M., Castro, V., Llobet-Navas, D., Birnbaum, D., Finetti, P., Woodward, W. A., Bertucci, F., Alpaugh, M., Califano, A. & Silva, J., Apr 19 2017, In : Breast Cancer Research. 19, 1, 49.

    Research output: Contribution to journalComment/debate

    Inflammatory Breast Neoplasms
    Publications
    Breast Neoplasms

    Press/Media