Nathaniel Nucci

Rowan University

    • 893 Citations
    • 16 h-Index
    20042020
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    Personal profile

    Research interests

    Research Expertise:
    NMR Spectroscopy | Reverse Micelle Technology | Protein Biophysics

    Nuclear Magnetic Resonance (NMR) is a state-of-the-art spectroscopic method that provides both spatial and temporal information on the atomic level. This technology is especially insightful when examining macromolecules, but various technical challenges limit the size of the molecules that can be easily studied. I have unique expertise in the application of reverse micelle technology to the NMR-based investigation of macromolecular structure and dynamics. This special skill set allows my research group to ask a range of innovative questions about the ways biological systems function at the molecular level. In addition to NMR, we utilize UV/Visible absorption and fluorescence spectroscopy to investigate biomolecular structure and function. We are also developing an apparatus that combined fluorescence correlation microscopy with microfluidics to study chemical dynamics and the impacts of macromolecular crowding on protein function. Present projects include study of antifreeze protein function, nanoscale confinement effects on protein structure and function, structure/function studies of the hypoxia-inducible factor prolyl hydroxylases, and applications of reverse micelles such as drug delivery and manufacture of quantum dots.

    Honors and Awards:  
    New Jersey Health Foundation Research Grant 2016-2017

    Member of:
    American Association for the Advancement of Science
    Biophysical Society
    American Chemical Society

    Education/Academic qualification

    University of Pennsylvania

    Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

    Micelles Chemical Compounds
    Water Chemical Compounds
    Proteins Chemical Compounds
    Biomolecular Nuclear Magnetic Resonance Medicine & Life Sciences
    Viscosity Medicine & Life Sciences
    Encapsulation Chemical Compounds
    Nuclear magnetic resonance Chemical Compounds
    Glycerol Chemical Compounds

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    Projects 2016 2020

    Research Output 2004 2018

    • 893 Citations
    • 16 h-Index
    • 22 Article
    • 2 Review article
    • 1 Letter
    1 Citation (Scopus)

    Toward comprehensive measurement of protein hydration dynamics: Facilitation of NMR-based methods by reverse micelle encapsulation

    Gallo, P. N., Iovine, J. C. & Nucci, N., Sep 15 2018, In : Methods. 148, p. 146-153 8 p.

    Rowan University

    Research output: Contribution to journalReview article

    Micelles
    Encapsulation
    Hydration
    Nuclear magnetic resonance
    Water
    Phosphoproteins
    Entropy
    Calcium Signaling
    S100 Proteins
    Proteins
    21 Citations (Scopus)

    Defining the apoptotic trigger: The interaction of cytochrome c and cardiolipin

    O'Brien, E. S., Nucci, N., Fuglestad, B., Tommos, C. & Wand, A. J., Dec 25 2015, In : Journal of Biological Chemistry. 290, 52, p. 30879-30887 9 p.

    Rowan University

    Research output: Contribution to journalArticle

    Cardiolipins
    Cytochromes c
    Apoptosis
    Protein Unfolding
    Micelles
    21 Citations (Scopus)

    High-resolution NMR spectroscopy of encapsulated proteins dissolved in low-viscosity fluids

    Nucci, N., Valentine, K. G. & Wand, A. J., Jan 1 2014, In : Journal of Magnetic Resonance. 241, 1, p. 137-147 11 p.

    Rowan University

    Research output: Contribution to journalArticle

    Biomolecular Nuclear Magnetic Resonance
    Macromolecules
    macromolecules
    Viscosity
    Nuclear magnetic resonance spectroscopy