Nathaniel Nucci

Rowan University

    • 1012 Citations
    • 16 h-Index
    20042025

    Research output per year

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    Personal profile

    Research interests

    Research Expertise:
    NMR Spectroscopy | Reverse Micelle Technology | Protein Biophysics

    Nuclear Magnetic Resonance (NMR) is a state-of-the-art spectroscopic method that provides both spatial and temporal information on the atomic level. This technology is especially insightful when examining macromolecules, but various technical challenges limit the size of the molecules that can be easily studied. I have unique expertise in the application of reverse micelle technology to the NMR-based investigation of macromolecular structure and dynamics. This special skill set allows my research group to ask a range of innovative questions about the ways biological systems function at the molecular level. In addition to NMR, we utilize UV/Visible absorption and fluorescence spectroscopy to investigate biomolecular structure and function. We are also developing an apparatus that combined fluorescence correlation microscopy with microfluidics to study chemical dynamics and the impacts of macromolecular crowding on protein function. Present projects include study of antifreeze protein function, nanoscale confinement effects on protein structure and function, structure/function studies of the hypoxia-inducible factor prolyl hydroxylases, and applications of reverse micelles such as drug delivery and manufacture of quantum dots.

    Honors and Awards:  
    New Jersey Health Foundation Research Grant 2016-2017

    Member of:
    American Association for the Advancement of Science
    Biophysical Society
    American Chemical Society

    Education/Academic qualification

    University of Pennsylvania

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    Projects

    Research Output

    • 1012 Citations
    • 16 h-Index
    • 22 Article
    • 2 Review article
    • 1 Letter

    Toward comprehensive measurement of protein hydration dynamics: Facilitation of NMR-based methods by reverse micelle encapsulation

    Gallo, P. N., Iovine, J. C. & Nucci, N., Sep 15 2018, In : Methods. 148, p. 146-153 8 p.

    Rowan University

    Research output: Contribution to journalReview article

  • 6 Scopus citations
  • 1 Scopus citations

    Defining the apoptotic trigger: The interaction of cytochrome c and cardiolipin

    O'Brien, E. S., Nucci, N. V., Fuglestad, B., Tommos, C. & Wand, A. J., Dec 25 2015, In : Journal of Biological Chemistry. 290, 52, p. 30879-30887 9 p.

    Rowan University

    Research output: Contribution to journalArticle

  • 32 Scopus citations

    High-resolution NMR spectroscopy of encapsulated proteins dissolved in low-viscosity fluids

    Nucci, N. V., Valentine, K. G. & Wand, A. J., Apr 2014, In : Journal of Magnetic Resonance. 241, 1, p. 137-147 11 p.

    Rowan University

    Research output: Contribution to journalArticle

  • 30 Scopus citations