Research output per year
Research output per year
- 1 - 50 out of 66 results
Search results
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2024
Over-expression of N-acetylaspartate synthase exacerbates pathological energetic deficit and accelerates cognitive decline in the 5xFAD mouse
Francis, J. S., Nguyen, Q., Markov, V. & Leone, P., Feb 2024, In: Journal of neurochemistry. 168, 2, p. 69-82 14 p.Research output: Contribution to journal › Article › peer-review
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2021
Evidence that Maackia amurensis seed lectin (MASL) exerts pleiotropic actions on oral squamous cells with potential to inhibit SARS-CoV-2 infection and COVID-19 disease progression
Sheehan, S. A., Hamilton, K. L., Retzbach, E. P., Balachandran, P., Krishnan, H., Leone, P., Lopez-Gonzalez, M., Suryavanshi, S., Kumar, P., Russo, R. & Goldberg, G. S., Jun 1 2021, In: Experimental cell research. 403, 1, 112594.Research output: Contribution to journal › Article › peer-review
Open Access -
Preclinical biodistribution, tropism, and efficacy of oligotropic AAV/Olig001 in a mouse model of congenital white matter disease
Francis, J. S., Markov, V., Wojtas, I. D., Gray, S., McCown, T., Samulski, R. J., Figueroa, M. & Leone, P., Mar 12 2021, In: Molecular Therapy Methods and Clinical Development. 20, p. 520-534 15 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2020
Enhancement of behavioral and linguistic outcome measures in autism spectrum disorder through neuro-navigated transcranial magnetic stimulation: A pilot study
Assadi, M., Dave, J., Leone, P., Redjal, N. & Curtin, A., Apr 2020, In: Journal of Clinical Neuroscience. 74, p. 151-154 4 p.Research output: Contribution to journal › Article › peer-review
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2016
N-acetylaspartate supports the energetic demands of developmental myelination via oligodendroglial aspartoacylase
Francis, J. S., Wojtas, I., Markov, V., Gray, S. J., McCown, T. J., Samulski, R. J., Bilaniuk, L. T., Wang, D. J., De Vivo, D. C. & Leone, P., Dec 1 2016, In: Neurobiology of Disease. 96, p. 323-334 12 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
2015
Transcriptional regulation of N-acetylaspartate metabolism in the 5xFAD model of Alzheimer's disease: Evidence for neuron-glia communication during energetic crisis
Zaroff, S., Leone, P., Markov, V. & Francis, J. S., Mar 1 2015, In: Molecular and Cellular Neuroscience. 65, p. 143-152 10 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
2014
Clinical applications involving CNS gene transfer
Kantor, B., McCown, T., Leone, P. & Gray, S. J., 2014, Advances in Genetics. Academic Press Inc., p. 71-124 54 p. (Advances in Genetics; vol. 87).Research output: Chapter in Book/Report/Conference proceeding › Chapter
Open Access38 Scopus citations -
Comparison of endovascular and intraventricular gene therapy with adeno-associated virus-α-L-iduronidase for hurler disease
Romanova, L. G., Leone, P., Nan, Z., Belur, L., Scott Mclvor, R. & Low, W., Jan 2014, In: Neurosurgery. 74, 1, p. 99-111 13 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Dietary triheptanoin rescues oligodendrocyte loss, dysmyelination and motor function in the nur7 mouse model of Canavan disease
Francis, J. S., Markov, V. & Leone, P., May 2014, In: Journal of Inherited Metabolic Disease. 37, 3, p. 369-381 13 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival
Gautier, E. L., Ivanov, S., Williams, J. W., Huang, S. C. C., Marcelin, G., Fairfax, K., Wang, P. L., Francis, J. S., Leone, P., Wilson, D. B., Artyomov, M. N., Pearce, E. J. & Randolph, G. J., 2014, In: Journal of Experimental Medicine. 211, 8, p. 1525-1531 7 p.Research output: Contribution to journal › Article › peer-review
Open Access111 Scopus citations -
2013
Does the parental history of headaches influence the severity of migraine in the offspring?
Assadi, M. S., Zerafati, G., Velazquez-Rodriquez, Y., Contreras, L. & Leone, P., 2013, In: Journal of Pediatric Neurology. 11, 1, p. 15-21 7 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
The phenotypic differences between probable migraine and definite migraine in teenage girls
Assadi, M., Zerafati, G., Velazquez, Y. & Leone, P., 2013, In: Journal of Pediatric Neurology. 11, 3, p. 171-175 5 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
2012
Aspartoacylase supports oxidative energy metabolism during myelination
Francis, J. S., Strande, L., Markov, V. & Leone, P., Sep 2012, In: Journal of Cerebral Blood Flow and Metabolism. 32, 9, p. 1725-1736 12 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
Long-term follow-up after gene therapy for canavan disease
Leone, P., Shera, D., McPhee, S. W. J., Francis, J. S., Kolodny, E. H., Bilaniuk, L. T., Wang, D. J., Assadi, M., Goldfarb, O., Goldman, H. W., Freese, A., Young, D., During, M. J. & Samulski, R. J., Dec 19 2012, In: Science translational medicine. 4, 165, 165ra163.Research output: Contribution to journal › Article › peer-review
Open Access152 Scopus citations -
The prevalence, burden and cognizance of migraine in adolescent girls
Assadi, M., Zerafati, G., Dham, B. S., Contreras, L., Akbar, U., Zayas, L. & Leone, P., 2012, In: Journal of Pediatric Neurology. 10, 1, p. 29-34 6 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
2011
Endogenous aspartoacylase expression is responsive to glutamatergic activity in vitro and in vivo
Francis, J. S., Strande, L., Pu, A. & Leone, P., Oct 2011, In: Glia. 59, 10, p. 1435-1446 12 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
2010
Lithium citrate reduces excessive intra-cerebral N-acetyl aspartate in Canavan disease
Assadi, M., Wang, D. J., Goldfarb, O., Suri, N., Bilaniuk, L. & Leone, P., Jul 2010, In: European Journal of Paediatric Neurology. 14, 4, p. 354-359 6 p.Research output: Contribution to journal › Article › peer-review
33 Scopus citations -
2009
Myelin lipid abnormalities in the aspartoacylase-deficient tremor rat
Wang, J., Leone, P., Wu, G., Francis, J. S., Li, H., Jain, M. R., Serikawa, T. & Ledeen, R. W., Jan 2009, In: Neurochemical Research. 34, 1, p. 138-148 11 p.Rowan University, Rutgers, The State University
Research output: Contribution to journal › Article › peer-review
Open Access31 Scopus citations -
2008
Angiopoietin 2 concentrations in infants developing bronchopulmonary dysplasia: Attenuation by dexamethasone
Aghai, Z. H., Faqiri, S., Saslow, J. G., Nakhla, T., Farhath, S., Kumar, A., Eydelman, R., Strande, L., Stahl, G., Leone, P. & Bhandari, V., Feb 2008, In: Journal of Perinatology. 28, 2, p. 149-155 7 p.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
Serial 1H-MRS in GM2 gangliosidoses
Assadi, M., Baseman, S., Wang, D. J., Bilaniuk, L. & Leone, P., Mar 2008, In: European Journal of Pediatrics. 167, 3, p. 347-352 6 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Validating an Ataxia Functional Composite Scale in spinocerebellar ataxia
Assadi, M., Leone, P., Veloski, J. J., Schwartzman, R. J. & Campellone, J. V., May 15 2008, In: Journal of the Neurological Sciences. 268, 1-2, p. 136-139 4 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
2007
Azithromycin suppresses activation of nuclear factor-kappa B and synthesis of pro-inflammatory cytokines in tracheal aspirate cells from premature infants
Aghai, Z. H., Kode, A., Saslow, J. G., Nakhla, T., Farhath, S., Stahl, G. E., Eydelman, R., Strande, L., Leone, P. & Rahman, I., Oct 2007, In: Pediatric Research. 62, 4, p. 483-488 6 p.Research output: Contribution to journal › Article › peer-review
Open Access98 Scopus citations -
GFP-transgenic Lewis rats as a cell source for oligodendrocyte replacement
Francis, J. S., Olariu, A., Kobayashi, E. & Leone, P., May 2007, In: Experimental Neurology. 205, 1, p. 177-189 13 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Treatment of spinocerebellar ataxia with buspirone
Assadi, M., Campellone, J. V., Veloski, J. J., Schwartzman, R. J. & Leone, P., Sep 15 2007, In: Journal of the Neurological Sciences. 260, 1-2, p. 143-146 4 p.Research output: Contribution to journal › Article › peer-review
22 Scopus citations -
2006
Immune responses to AAV in a phase I study for Canavan disease
McPhee, S. W. J., Li, C., Samulski, R. J., Camp, A. S., Francis, J., Shera, D., Lioutermann, L., Feely, M., Freese, A. & Leone, P., May 2006, In: Journal of Gene Medicine. 8, 5, p. 577-588 12 p.Research output: Contribution to journal › Article › peer-review
178 Scopus citations -
Mild-onset presentation of Canavan's disease associated with novel G212A point mutation in aspartoacylase gene
Kolodny, E. H., Zeng, B. J., Raghavan, S., Pastures, G., Torres, P., Assadi, M., McPhee, S., Goldfarb, O., Saslow, B., Freese, A., Wang, D. J., Bilaniuk, L., Shera, D. & Leone, P., Feb 2006, In: Annals of Neurology. 59, 2, p. 428-431 4 p.Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
Mutation analysis of the aspartoacylase gene in non-Jewish patients with Canavan disease
Zeng, B. J., Pastores, G. M., Leone, P., Raghavan, S., Wang, Z. H., Ribeiro, L. A., Torres, P., Ong, E. & Kolodny, E. H., 2006, N-Acetylaspartate: A Unique Neuronal Molecule in the Central Nervous System. Springer New York, p. 165-173 9 p. (Advances in Experimental Medicine and Biology; vol. 576).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
13 Scopus citations -
Natural history of Canavan disease revealed by proton magnetic resonance spectroscopy (1H-MRS) and diffusion-weighted MRI
McPhee, S. W. J., Francis, J., Shera, D., Assadi, M., Freese, A., Hurh, P., Haselgrove, J., Wang, D. J., Bilaniuk, L. & Leone, P., Aug 2006, In: Neuropediatrics. 37, 4, p. 209-221 13 p.Research output: Contribution to journal › Article › peer-review
58 Scopus citations -
Novel role for aspartoacylase in regulation of BDNF and timing of postnatal oligodendrogenesis
Francis, J. S., Olariu, A., McPhee, S. W. & Leone, P., Jul 2006, In: Journal of Neuroscience Research. 84, 1, p. 151-169 19 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Rapid detection of three large novel deletions of the aspartoacylase gene in non-Jewish patients with Canavan disease
Zeng, B. J., Wang, Z. H., Torres, P. A., Pastores, G. M., Leone, P., Raghavan, S. S. & Kolodny, E. H., Sep 2006, In: Molecular Genetics and Metabolism. 89, 1-2, p. 156-163 8 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
2005
Development of new inbred transgenic strains of rats with LacZ or GFP
Inoue, H., Ohsawa, I., Murakami, T., Kimura, A., Hakamata, Y., Sato, Y., Takahashi, M., Okada, T., Ozawa, K., Francis, J., Leone, P. & Kobayashi, E., Apr 1 2005, In: Biochemical and Biophysical Research Communications. 329, 1, p. 288-295 8 p.Research output: Contribution to journal › Article › peer-review
103 Scopus citations -
Effects of AAV-2-mediated aspartoacylase gene transfer in the tremor rat model of Canavan disease
McPhee, S. W. J., Francis, J., Serikawa, T., Hyland, K., Ong, E. O., Raghavan, S. S., Freese, A. & Leone, P., Apr 27 2005, In: Molecular Brain Research. 135, 1-2, p. 112-121 10 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
Lithium citrate for Canavan disease
Assadi, M., Francis, J., Bilaniuk, L., Shera, D. & Leone, P., Oct 2005, In: Pediatric Neurology. 33, 4, p. 235-243 9 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
Simultaneous high performance liquid chromatographic separation of purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemical diagnosis of inborn errors of metabolism
Tavazzi, B., Lazzarino, G., Leone, P., Amorini, A. M., Bellia, F., Di Pietro, V., Ceccarelli, L., Donzelli, S., Francis, J. S. & Giardina, B., Nov 2005, In: Clinical Biochemistry. 38, 11, p. 997-1008 12 p.Research output: Contribution to journal › Article › peer-review
79 Scopus citations -
2003
Adeno-associated viral vector gene expression in the adult rat spinal cord following remote vector delivery
Boulis, N. M., Noordmans, A. J., Song, D. K., Imperiale, M. J., Rubin, A., Leone, P., During, M. & Feldman, E. L., Dec 2003, In: Neurobiology of Disease. 14, 3, p. 535-541 7 p.Research output: Contribution to journal › Article › peer-review
46 Scopus citations -
Transcriptional activation of human CREB gene promoter using bis-PNA (peptide nucleic acid)
During, M., Shifman, Y. & Leone, P., 2003, In: Letters in Peptide Science. 10, 3-4, p. 373-376 4 p.Research output: Contribution to journal › Article › peer-review
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2002
Gene therapy of Canavan disease: AAV-2 vector for neurosurgical delivery of aspartoacylase gene (ASPA) to the human brain
McPhee, S., Bilaniuk, L., Haselgrove, J., Testaiuti, M., Freese, A., Wang, D. J., Shera, D., Hurh, P., Rupin, J., Saslow, E., Goldfarb, O., Goldberg, M., Larijani, G., Sharrar, W., Liouterman, L., Camp, A., Kolodny, E., Samulski, J. & Leone, P., Jul 20 2002, In: Human gene therapy. 13, 11, p. 1391-1412 22 p.Research output: Contribution to journal › Article › peer-review
187 Scopus citations -
Indentification and characterization of novel mutations of the aspartoacylase gene in non-Jewish patients with Canavan disease
Zeng, B. J., Wang, Z. H., Ribeiro, L. A., Leone, P., De Gasperi, R., Kim, S. J., Raghavan, S., Ong, E., Pastores, G. M. & Kolodny, E. H., Nov 2002, In: Journal of Inherited Metabolic Disease. 25, 7, p. 557-570 14 p.Research output: Contribution to journal › Review article › peer-review
56 Scopus citations -
Striking differences in glucose and lactate levels between brain extracellular fluid and plasma in conscious human subjects: Effects of hyperglycemia and hypoglycemia
Abi-Saab, W. M., Maggs, D. G., Jones, T., Jacob, R., Srihari, V., Thompson, J., Kerr, D., Leone, P., Krystal, J. H., Spencer, D. D., During, M. J. & Sherwin, R. S., 2002, In: Journal of Cerebral Blood Flow and Metabolism. 22, 3, p. 271-279 9 p.Research output: Contribution to journal › Article › peer-review
Open Access156 Scopus citations -
2001
Human intrathecal transplantation of peripheral blood stem cells in amyotrophic lateral sclerosis
Ramesh, T. M., During, M. J., Leone, P. & Heywood, J., 2001, In: Journal of Hematotherapy and Stem Cell Research. 10, 6, p. 913-915 3 p.Research output: Contribution to journal › Article › peer-review
70 Scopus citations -
Quantitative comparison of expression with adeno-associated virus (AAV-2) brain-specific gene cassettes
Xu, R., Mastakov, M., Lawlor, P., Young, D., Mouravlev, A., Fitzsimons, H., Choi, K. L., Ma, H., Dragunow, M., Leone, P., Chen, Q., Dicker, B. & During, M. J., 2001, In: Gene therapy. 8, 17, p. 1323-1332 10 p.Research output: Contribution to journal › Article › peer-review
144 Scopus citations -
Viral-based gene transfer to the mammalian CNS for functional genomic studies
McPhee, S. W. J., Leone, P., Freese, A. & During, M. J., Dec 1 2001, In: Trends in Neurosciences. 24, 12, p. 706-712 7 p.Research output: Contribution to journal › Review article › peer-review
41 Scopus citations -
2000
An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy
During, M. J., Symes, C. W., Lawlor, P. A., Lin, J., Dunning, J., Fitzsimons, H. L., Poulsen, D., Leone, P., Xu, R., Dicker, B. L., Lipski, J. & Young, D., Feb 25 2000, In: Science. 287, 5457, p. 1453-1460 8 p.Research output: Contribution to journal › Article › peer-review
189 Scopus citations -
Aspartoacylase gene transfer to the mammalian central nervous system with therapeutic implications for Canavan disease
Leone, P., Bilianuk, L., Wang, Z., Sorgi, F., Huang, L., Matalon, R., Kaul, R., Zeng, Z., Freese, A., McPhee, S. W., Mee, E. & During, M. J., 2000, In: Annals of Neurology. 48, 1, p. 27-38 12 p.Research output: Contribution to journal › Article › peer-review
125 Scopus citations -
Erratum: (Annals of Neurology (2000) 48 (27-38))
Leone, P., Bilianuk, L., Wang, Z., Sorgi, F., Huang, L., Matalon, R., Kaul, R., Zeng, Z., Freese, A., McPhee, S. W., Mee, E. & During, M. J., 2000, In: Annals of Neurology. 48, 3, p. 398 1 p.Research output: Contribution to journal › Comment/debate › peer-review
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Multi-site partitioned delivery of human tyrosine hydroxylase gene with phenotypic recovery in Parkinsonian rats
Leone, P., McPhee, S. W. J., Davidson, B. L., Freese, A. & During, M. J., Apr 27 2000, In: NeuroReport. 11, 6, p. 1145-1151 7 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
Overexpression of GluR6 in rat hippocampus produces seizures and spontaneous nonsynaptic bursting in vitro
Telfeian, A. E., Federoff, H. J., Leone, P., During, M. J. & Williamson, A., 2000, In: Neurobiology of Disease. 7, 4, p. 362-374 13 p.Research output: Contribution to journal › Article › peer-review
40 Scopus citations -
1999
Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective
Young, D., Lawlor, P. A., Leone, P., Dragunow, M. & During, M. J., Apr 1999, In: Nature medicine. 5, 4, p. 448-453 6 p.Research output: Contribution to journal › Article › peer-review
619 Scopus citations -
Erratum: Global CNS gene transfer for a childhood neurogenetic enzyme deficiency: Canavan disease (Current Opinion in Molecular Therapeutics (1999) 1:4 (487-491))
Leone, P., McPhee, S. J. & During, M. J., 1999, In: Current Opinion in Molecular Therapeutics. 1, 5, p. 658 1 p.Research output: Contribution to journal › Comment/debate › peer-review
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Global CNS gene transfer for a childhood neurogenetic enzyme deficiency: Canavan disease
Leone, P., McPhee, S. J. & During, M. J., 1999, In: Current Opinion in Molecular Therapeutics. 1, 4, p. 487-492 6 p.Research output: Contribution to journal › Review article › peer-review
40 Scopus citations