• 4855 Citations
  • 37 h-Index
1976 …2020

Research output per year

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Research Output

2020

Alzheimer's/Vascular Spectrum Dementia: Classification in Addition to Diagnosis

Emrani, S., Lamar, M., Price, C. C., Wasserman, V., Matusz, E., Au, R., Swenson, R., Nagele, R., Heilman, K. M. & Libon, D. J., Jan 1 2020, In : Journal of Alzheimer's Disease. 73, 1, p. 63-71 9 p.

Rowan University

Research output: Contribution to journalArticle

1 Scopus citations
2019

Antibodies in the diagnosis, prognosis, and prediction of psychotic disorders

Pollak, T. A., Rogers, J. P., Nagele, R. G., Peakman, M., Stone, J. M., David, A. S. & McGuire, P., Jan 1 2019, In : Schizophrenia bulletin. 45, 1, p. 233-246 14 p.

Rowan University

Research output: Contribution to journalArticle

2 Scopus citations

Detection of early-stage Alzheimer’s pathology using blood-based autoantibody biomarkers in elderly hip fracture repair patients

DeMarshall, C., Oh, E., Kheirkhah, R., Sieber, F., Zetterberg, H., Blennow, K. & Nagele, R. G., Jan 1 2019, In : PLoS ONE. 14, 11, e0225178.

Rowan University

Research output: Contribution to journalArticle

Open Access

Harnessing neurovascular interaction to guide axon growth

Partyka, P. P., Jin, Y., Bouyer, J., DaSilva, A., Godsey, G. A., Nagele, R. G., Fischer, I. & Galie, P. A., Dec 1 2019, In : Scientific reports. 9, 1, 2190.

Rowan University

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2017

Autoantibodies as diagnostic biomarkers for the detection and subtyping of multiple sclerosis

DeMarshall, C., Goldwaser, E. L., Sarkar, A., Godsey, G. A., Acharya, N. K., Thayasivam, U., Belinka, B. A. & Nagele, R. G., Aug 15 2017, In : Journal of Neuroimmunology. 309, p. 51-57 7 p.

Rowan University

Research output: Contribution to journalArticle

6 Scopus citations

Mechanical stress regulates transport in a compliant 3D model of the blood-brain barrier

Partyka, P. P., Godsey, G. A., Galie, J. R., Kosciuk, M. C., Acharya, N. K., Nagele, R. G. & Galie, P. A., Jan 1 2017, In : Biomaterials. 115, p. 30-39 10 p.

Rowan University

Research output: Contribution to journalArticle

39 Scopus citations

Retinal pathology is associated with increased blood-retina barrier permeability in a diabetic and hypercholesterolaemic pig model: Beneficial effects of the LpPLA2 inhibitor Darapladib

Acharya, N. K., Qi, X., Goldwaser, E. L., Godsey, G. A., Wu, H., Kosciuk, M. C., Freeman, T. A., Macphee, C. H., Wilensky, R. L., Venkataraman, V. & Nagele, R. G., Jan 1 2017, In : Diabetes and Vascular Disease Research. 14, 3, p. 200-213 14 p.

Rowan University

Research output: Contribution to journalArticle

13 Scopus citations
2016

Age-dependent increase of blood-brain barrier permeability and neuron-binding autoantibodies in S100B knockout mice

Wu, H., Brown, E. V., Acharya, N. K., Appelt, D. M., Marks, A., Nagele, R. G. & Venkataraman, V., Apr 15 2016, In : Brain research. 1637, p. 154-167 14 p.

Rowan University

Research output: Contribution to journalArticle

11 Scopus citations

Breakdown of the Cerebrovasculature and Blood-Brain Barrier: A Mechanistic Link between Diabetes Mellitus and Alzheimer's Disease

Goldwaser, E. L., Acharya, N. K., Sarkar, A., Godsey, G. & Nagele, R. G., Sep 6 2016, In : Journal of Alzheimer's Disease. 54, 2, p. 445-456 12 p.

Rowan University

Research output: Contribution to journalReview article

15 Scopus citations
30 Scopus citations
2015
6 Scopus citations

Potential utility of autoantibodies as blood-based biomarkers for early detection and diagnosis of Parkinson's disease

The Parkinson's Study Group Investigators, Nov 1 2015, In : Immunology Letters. 168, 1, p. 80-88 9 p.

Rowan University

Research output: Contribution to journalArticle

18 Scopus citations

Sevoflurane and Isoflurane induce structural changes in brain vascular endothelial cells and increase blood-brain barrier permeability: Possible link to postoperative delirium and cognitive decline

Acharya, N. K., Goldwaser, E. L., Forsberg, M. M., Godsey, G. A., Johnson, C. A., Sarkar, A., DeMarshall, C., Kosciuk, M. C., Dash, J. M., Hale, C. P., Leonard, D. M., Appelt, D. M. & Nagele, R. G., Sep 16 2015, In : Brain research. 1620, p. 29-41 13 p., 44240.

Rowan University

Research output: Contribution to journalArticle

35 Scopus citations

Utility of Autoantibodies as Biomarkers for Diagnosis and Staging of Neurodegenerative Diseases

DeMarshall, C., Sarkar, A., Nagele, E. P., Goldwaser, E., Godsey, G., Acharya, N. K. & Nagele, R., Jan 1 2015, International Review of Neurobiology: Omic Studies of Neurodegenerative Disease: Part B, 2015. Hurley, M. J. (ed.). Academic Press Inc., p. 1-51 51 p. (International Review of Neurobiology; vol. 122).

Rowan University

Research output: Chapter in Book/Report/Conference proceedingConference contribution

22 Scopus citations
2013

Autoantibodies: Double agents in human disease

Acharya, N. K., Nagele, E. P., Han, M. & Nagele, R., May 22 2013, In : Science translational medicine. 5, 186, 186fs19.

Research output: Contribution to journalComment/debate

6 Scopus citations

Diabetes and hypercholesterolemia increase blood-brain barrier permeability and brain amyloid deposition: Beneficial effects of the LpPLA2 inhibitor darapladib

Acharya, N. K., Levin, E. C., Clifford, P. M., Han, M., Tourtellotte, R., Chamberlain, D., Pollaro, M., Coretti, N. J., Kosciuk, M. C., Nagele, E. P., Demarshall, C., Freeman, T., Shi, Y., Guan, C., MacPhee, C. H., Wilensky, R. L. & Nagele, R. G., 2013, In : Journal of Alzheimer's Disease. 35, 1, p. 179-198 20 p.

Rowan University

Research output: Contribution to journalArticle

61 Scopus citations

Natural IgG Autoantibodies Are Abundant and Ubiquitous in Human Sera, and Their Number Is Influenced By Age, Gender, and Disease

Nagele, E. P., Han, M., Acharya, N. K., DeMarshall, C., Kosciuk, M. C. & Nagele, R. G., Apr 2 2013, In : PLoS ONE. 8, 4, e60726.

Rowan University

Research output: Contribution to journalArticle

124 Scopus citations
2012

Diagnosis of parkinson's disease based on disease-specific autoantibody profiles in human sera

Han, M., Nagele, E., DeMarshall, C., Acharya, N. & Nagele, R., Feb 22 2012, In : PLoS ONE. 7, 2, e32383.

Rowan University

Research output: Contribution to journalArticle

59 Scopus citations

Neuronal PAD4 expression and protein citrullination: Possible role in production of autoantibodies associated with neurodegenerative disease

Acharya, N. K., Nagele, E. P., Han, M., Coretti, N. J., DeMarshall, C., Kosciuk, M. C., Boulos, P. A. & Nagele, R., Jun 1 2012, In : Journal of Autoimmunity. 38, 4, p. 369-380 12 p.

Research output: Contribution to journalArticle

49 Scopus citations

Plant lectin can target receptors containing sialic acid, exemplified by podoplanin, to inhibit transformed cell growth and migration

Ochoa-Alvarez, J. A., Krishnan, H., Shen, Y., Acharya, N. K., Han, M., McNulty, D. E., Hasegawa, H., Hyodo, T., Senga, T., Geng, J. G., Kosciuk, M., Shin, S. S., Temiakov, D., Nagele, R. G., Goldberg, G. S. & Goydos, J. S., Jul 23 2012, In : PLoS ONE. 7, 7, e41845.

Rutgers, The State University, Rowan University

Research output: Contribution to journalArticle

2011

Brain-reactive autoantibodies prevalent in human sera increase intraneuronal amyloid-β1-42 deposition

Nagele, R. G., Clifford, P. M., Siu, G., Levin, E. C., Acharya, N. K., Han, M., Kosciuk, M. C., Venkataraman, V., Zavareh, S., Zarrabi, S., Kinsler, K., Thaker, N. G., Nagele, E. P., Dash, J., Wang, H. Y. & Levitas, A., 2011, In : Journal of Alzheimer's Disease. 25, 4, p. 605-622 18 p.

Rowan University

Research output: Contribution to journalArticle

43 Scopus citations

Diagnosis of Alzheimer's disease based on disease-specific autoantibody profiles in human sera

Nagele, E., Han, M., DeMarshall, C., Belinka, B. & Nagele, R., Aug 8 2011, In : PLoS ONE. 6, 8, e23112.

Rowan University

Research output: Contribution to journalArticle

95 Scopus citations

Prenatal cocaine exposure increases synaptic localization of a neuronal RasGEF, GRASP-1 via hyperphosphorylation of AMPAR anchoring protein, GRIP

Bakshi, K., Kosciuk, M., Nagele, R. G., Friedman, E. & Wang, H. Y., Sep 27 2011, In : PLoS ONE. 6, 9, e25019.

Rowan University

Research output: Contribution to journalArticle

8 Scopus citations
2010

Brain-reactive autoantibodies are nearly ubiquitous in human sera and may be linked to pathology in the context of blood-brain barrier breakdown

Levin, E. C., Acharya, N. K., Han, M., Zavareh, S. B., Sedeyn, J. C., Venkataraman, V. & Nagele, R. G., Jul 23 2010, In : Brain research. 1345, p. 221-232 12 p.

Rowan University

Research output: Contribution to journalArticle

73 Scopus citations
20 Scopus citations

Simultaneous PCNA and TUNEL labeling for testicular toxicity evaluation suggests that detection of apoptosis may be more sensitive than proliferation

D'andrea, M. R., Alicknavitch, M., Nagele, R. & Damiano, B. P., May 10 2010, In : Biotechnic and Histochemistry. 85, 3, p. 195-204 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
2009

Neuronal expression of vimentin in the Alzheimer's disease brain may be part of a generalized dendritic damage-response mechanism

Levin, E. C., Acharya, N. K., Sedeyn, J. C., Venkataraman, V., D'Andrea, M. R., Wang, H. Y. & Nagele, R. G., Oct 28 2009, In : Brain research. 1298, p. 194-207 14 p.

Rowan University

Research output: Contribution to journalArticle

40 Scopus citations

Prenatal cocaine reduces AMPA receptor synaptic expression through hyperphosphorylation of the synaptic anchoring protein GRIP

Bakshi, K., Gennaro, S., Chan, C. Y., Kosciuk, M., Liu, J. J., Stucky, A., Trenkner, E., Friedman, E., Nagele, R. G. & Wang, H. Y., May 13 2009, In : Journal of Neuroscience. 29, 19, p. 6308-6319 12 p.

Rowan University

Research output: Contribution to journalArticle

18 Scopus citations
2008

Coordinate suppression of Sdpr and Fhl1 expression in tumors of the breast, kidney, and prostate

Li, X., Jia, Z., Shen, Y., Ichikawa, H., Jarvik, J., Nagele, R. & Goldberg, G., Jul 1 2008, In : Cancer Science. 99, 7, p. 1326-1333 8 p.

Rowan University

Research output: Contribution to journalArticle

53 Scopus citations

PCNA indexing as a preclinical immunohistochemical biomarker for testicular toxicity

Lawrence, D., Nagele, R., Wang, C. Y. & Damiano, B. P., Dec 5 2008, In : Biotechnic and Histochemistry. 83, 5, p. 211-220 10 p.

Rowan University

Research output: Contribution to journalArticle

13 Scopus citations

α7 nicotinic acetylcholine receptor expression by vascular smooth muscle cells facilitates the deposition of Aβ peptides and promotes cerebrovascular amyloid angiopathy

Clifford, P. M., Siu, G., Kosciuk, M., Levin, E. C., Venkataraman, V., D'Andrea, M. R. & Nagele, R. G., Oct 9 2008, In : Brain research. 1234, p. 158-171 14 p.

Rowan University

Research output: Contribution to journalArticle

30 Scopus citations
2007

Aβ peptides can enter the brain through a defective blood-brain barrier and bind selectively to neurons

Clifford, P. M., Zarrabi, S., Siu, G., Kinsler, K. J., Kosciuk, M. C., Venkataraman, V., D'Andrea, M. R., Dinsmore, S. & Nagele, R. G., Apr 20 2007, In : Brain research. 1142, 1, p. 223-236 14 p.

Rowan University

Research output: Contribution to journalArticle

103 Scopus citations

Glial cells and aβ peptides in alzheimer's disease pathogenesis

Siu, G., Clifford, P., Kosciuk, M., Venkataraman, V. & Nagele, R., Dec 1 2007, Abeta Peptide and Alzheimer's Disease: Celebrating a Century of Research. Springer London, p. 216-233 18 p.

Rowan University

Research output: Chapter in Book/Report/Conference proceedingChapter

2006

Src uses Cas to suppress Fhl1 in order to promote nonanchored growth and migration of tumor cells

Shen, Y., Jia, Z., Nagele, R. G., Ichikawa, H. & Goldberg, G. S., Feb 1 2006, In : Cancer Research. 66, 3, p. 1543-1552 10 p.

Rowan University

Research output: Contribution to journalArticle

49 Scopus citations
108 Scopus citations
2004

Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease

Nagele, R. G., Wegiel, J., Venkataraman, V., Imaki, H., Wang, K. C. & Wegiel, J., Jan 1 2004, In : Neurobiology of Aging. 25, 5, p. 663-674 12 p.

Rowan University

Research output: Contribution to journalArticle

354 Scopus citations
2003

Astrocytes accumulate Aβ42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains

Nagele, R. G., D'Andrea, M. R., Lee, H., Venkataraman, V. & Wang, H. Y., May 9 2003, In : Brain research. 971, 2, p. 197-209 13 p.

Rowan University

Research output: Contribution to journalArticle

250 Scopus citations
2002
2 Scopus citations

Cerebellar diffuse amyloid plaques are derived from dendritic Aβ42 accumulations in Purkinje cells

Wang, H. Y., D'Andrea, M. R. & Nagele, R., Feb 20 2002, In : Neurobiology of Aging. 23, 2, p. 213-223 11 p.

Rowan University

Research output: Contribution to journalArticle

64 Scopus citations

Consistent immunohistochemical detection of intracellular β-amyloid42 in pyramidal neurons of Alzheimer's disease entorhinal cortex

D'Andrea, M. R., Nagele, R., Wang, H. Y. & Lee, D. H. S., Nov 29 2002, In : Neuroscience Letters. 333, 3, p. 163-166 4 p.

Rowan University

Research output: Contribution to journalArticle

68 Scopus citations

Intracellular accumulation of β-amyloid1-42 in neurons is facilitated by the α7 nicotinic acetylcholine receptor in Alzheimer's disease

Nagele, R. G., D'Andrea, M. R., Anderson, W. J. & Wang, H. Y., Mar 12 2002, In : Neuroscience. 110, 2, p. 199-211 13 p.

Rowan University

Research output: Contribution to journalArticle

332 Scopus citations

Lipofuscin and Aβ42 exhibit distinct distribution patterns in normal and Alzheimer's disease brains

D'Andrea, M. R., Nagele, R., Gumula, N. A., Reiser, P. A., Polkovitch, D. A., Hertzog, B. M. & Andrade-Gordon, P., Apr 19 2002, In : Neuroscience Letters. 323, 1, p. 45-49 5 p.

Research output: Contribution to journalArticle

39 Scopus citations
16 Scopus citations

Targeting intracellular Aβ42 for Alzheimer's disease drug discovery

D'Andrea, M. R., Lee, D. H. S., Wang, H. Y. & Nagele, R. G., Jun 1 2002, In : Drug Development Research. 56, 2, p. 194-200 7 p.

Rowan University

Research output: Contribution to journalReview article

12 Scopus citations
2001

A novel calcium-regulated membrane guanylate cyclase transduction system in the olfactory neuroepithehum

Duda, T., Jankowska, A., Venkataraman, V., Nagele, R. & Sharma, R. K., Oct 9 2001, In : Biochemistry. 40, 40, p. 12067-12077 11 p.

Rowan University

Research output: Contribution to journalArticle

40 Scopus citations

A novel human hexameric DNA helicase: Expression, purification and characterization

Biswas, E. E., Nagele, R. G. & Biswas, S., Apr 15 2001, In : Nucleic acids research. 29, 8, p. 1733-1740 8 p.

Rowan University

Research output: Contribution to journalArticle

6 Scopus citations

Colon epithelial cell death in 2,4,6-trinitrobenzenesulfonic acid-induced colitis is associated with increased inducible nitric-oxide synthase expression and peroxynitrite production

Yue, G., Lai, P. S., Yin, K., Sun, F. F., Nagele, R. G., Liu, X., Linask, K. K., Wang, C., Lin, K. T. & Wong, P. Y. K., Jun 1 2001, In : Journal of Pharmacology and Experimental Therapeutics. 297, 3, p. 915-925 11 p.

Research output: Contribution to journalArticle

56 Scopus citations

Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease

D'Andrea, M. R., Nagele, R., Wang, H. Y., Peterson, P. A. & Lee, D. H. S., Mar 15 2001, In : Histopathology. 38, 2, p. 120-134 15 p.

Rowan University

Research output: Contribution to journalArticle

279 Scopus citations

Negatively calcium-modulated membrane guanylate cyclase signaling system in the rat olfactory bulb

Duda, T., Venkataraman, V., Krishnan, A., Nagele, R. G. & Sharma, R. K., Apr 17 2001, In : Biochemistry. 40, 15, p. 4654-4662 9 p.

Rowan University

Research output: Contribution to journalArticle

33 Scopus citations

Pattern of cytokine and adhesion molecule mRNA in hapten-induced relapsing colon inflammation in the rat

Sun, F. F., Lai, P. S., Yue, G., Yin, K., Nagele, R. G., Tong, D. M., Krzesicki, R. F., Chin, J. E. & Wong, P. Y. K., Jan 1 2001, In : Inflammation. 25, 1, p. 33-45 13 p.

Research output: Contribution to journalArticle

60 Scopus citations