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Article
2020

Mechanisms of increased vascular stiffness down the aortic tree in aging, premenopausal female monkeys

Babici, D., Kudej, R. K., McNulty, T., Zhang, J., Oydanich, M., Berkman, T., Nishimura, K., Bishop, S. P., Vatner, D. & Vatner, S. F., Jul 1 2020, In : American journal of physiology. Heart and circulatory physiology. 319, 1, p. H222-H234

Rutgers, The State University

Research output: Contribution to journalArticle

Open Access
2019

Hsp22 overexpression induces myocardial hypertrophy, senescence and reduced life span through enhanced oxidative stress

Morin, D., Long, R., Panel, M., Laure, L., Taranu, A., Gueguen, C., Pons, S., Leoni, V., Caccia, C., Vatner, S. F., Vatner, D. E., Qiu, H., Depre, C., Berdeaux, A. & Ghaleh, B., Jun 2019, In : Free Radical Biology and Medicine. 137, p. 194-200 7 p.

Rutgers, The State University

Research output: Contribution to journalArticle

2 Scopus citations

Mechanisms of sex differences in exercise capacity

Oydanich, M., Babici, D., Zhang, J., Rynecki, N., Vatner, D. E. & Vatner, S. F., Jan 1 2019, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 316, 6, p. R832-R838

Rutgers, The State University

Research output: Contribution to journalArticle

7 Scopus citations
2018
3 Scopus citations

Antioxidant defense and protection against cardiac arrhythmias: Lessons from a mammalian hibernator (the woodchuck)

Zhao, Z., Kudej, R. K., Wen, H., Fefelova, N., Yan, L., Vatner, D. E., Vatner, S. F. & Xie, L. H., Aug 2018, In : FASEB Journal. 32, 8, p. 4229-4240 12 p.

Rutgers, The State University

Research output: Contribution to journalArticle

2 Scopus citations

Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14

Vatner, D., Zhang, J., Oydanich, M., Guers, J., Katsyuba, E., Yan, L., Sinclair, D., Auwerx, J. & Vatner, S., Aug 1 2018, In : Aging cell. 17, 4, e12751.

Rutgers, The State University

Research output: Contribution to journalArticle

6 Scopus citations
2017

CHRONICALLY IMPLANTED CARDIOVASCULAR INSTRUMENTATION.

Vatner, S. F., Franklin, D., Higgins, C. B., Van Citters, R. L., Fryer, T. B., Sandler, H., Rader, R. D., Meehan, J. P., Henriksen, J. K. C., Rothe, C. F. & Abel, F. L., Jan 1 2017, In : Chronically Implanted Cardiovasc Instrum.

Rutgers, The State University

Research output: Contribution to journalArticle

CHRONICALLY IMPLANTED CARDIOVASCULAR INSTRUMENTATION.

Stone, H. L., Stegall, H. F., Evans, J. M., Stanifer, R. R., Folts, J. D., Rowe, G. G., Fryer, T. B., Franklin, D., Van Citters, R. L., Vatner, S. F., Higgins, C. B. & White, S., Jan 1 2017, In : Chronically Implanted Cardiovasc Instrum.

Rutgers, The State University

Research output: Contribution to journalArticle

Disruption of adenylyl cyclase type 5 mimics exercise training

Guers, J. J., Zhang, J., Campbell, S. C., Oydanich, M., Vatner, D. E. & Vatner, S. F., Nov 1 2017, In : Basic research in cardiology. 112, 6, 59.

Rutgers, The State University

Research output: Contribution to journalArticle

9 Scopus citations
2016
10 Scopus citations

Extracellular Matrix Disarray as a Mechanism for Greater Abdominal Versus Thoracic Aortic Stiffness with Aging in Primates

Zhang, J., Zhao, X., Vatner, D. E., McNulty, T., Bishop, S., Sun, Z., Shen, Y. T., Chen, L., Meininger, G. A. & Vatner, S. F., Apr 1 2016, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 4, p. 700-706 7 p.

Rutgers, The State University

Research output: Contribution to journalArticle

16 Scopus citations
2015

Adenylyl cyclase type 5 deficiency protects against diet-induced obesity and insulin resistance

Ho, D., Zhao, X., Yan, L., Yuan, C., Zong, H., Vatner, D. E., Pessin, J. E. & Vatner, S. F., Jul 2015, In : Diabetes. 64, 7, p. 2636-2645 10 p.

Rutgers, The State University

Research output: Contribution to journalArticle

9 Scopus citations

Augmented vascular smooth muscle cell stiffness and adhesion when hypertension is superimposed on aging

Sehgel, N. L., Sun, Z., Hong, Z., Hunter, W. C., Hill, M. A., Vatner, D. E., Vatner, S. F. & Meininger, G. A., Feb 21 2015, In : Hypertension. 65, 2, p. 370-377 8 p.

New Jersey Institute of Technology, Rutgers, The State University

Research output: Contribution to journalArticle

59 Scopus citations
22 Scopus citations
11 Scopus citations
14 Scopus citations

Myocardial ischemic protection in natural mammalian hibernation

Yan, L., Kudej, R. K., Vatner, D. E. & Vatner, S. F., Jan 1 2015, In : Basic research in cardiology. 110, 2

Rutgers, The State University

Research output: Contribution to journalArticle

13 Scopus citations

Overexpression of adenylyl cyclase type 5 (AC5) confers a proarrhythmic substrate to the heart

Zhao, Z., Babu, G. J., Wen, H., Fefelova, N., Gordan, R., Sui, X., Yan, L., Vatner, D. E., Vatner, S. F. & Xie, L. H., Jan 1 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 308, 3, p. H240-H249

Rutgers, The State University

Research output: Contribution to journalArticle

10 Scopus citations
12 Scopus citations

Type 5 adenylyl cyclase disruption leads to enhanced exercise performance

Vatner, D. E., Yan, L., Lai, L., Yuan, C., Mouchiroud, L., Pachon, R. E., Zhang, J., Dillinger, J. G., Houtkooper, R. H., Auwerx, J. & Vatner, S. F., Dec 1 2015, In : Aging cell. 14, 6, p. 1075-1084 10 p.

Rutgers, The State University

Research output: Contribution to journalArticle

6 Scopus citations
2014
7 Scopus citations

'Reduced malignancy as a mechanism for longevity in mice with adenylyl cyclase type 5 disruption'

De Lorenzo, M. S., Chen, W., Baljinnyam, E., Carlini, M. J., La Perle, K., Bishop, S. P., Wagner, T. E., Rabson, A. B., Vatner, D. E., Puricelli, L. I. & Vatner, S. F., Feb 1 2014, In : Aging cell. 13, 1, p. 102-110 9 p.

Rutgers, The State University

Research output: Contribution to journalArticle

9 Scopus citations
2013

Calorie restriction can reverse, as well as prevent, aging cardiomyopathy

Yan, L., Gao, S., Ho, D., Park, M., Ge, H., Wang, C., Tian, Y., Lai, L., De Lorenzo, M. S., Vatner, D. E. & Vatner, S. F., Dec 1 2013, In : Age. 35, 6, p. 2177-2182 6 p.

Rutgers, The State University

Research output: Contribution to journalArticle

31 Scopus citations

Increased vascular smooth muscle cell stiffness: A novel mechanism for aortic stiffness in hypertension

Sehgel, N. L., Zhu, Y., Sun, Z., Trzeciakowski, J. P., Hong, Z., Hunter, W. C., Vatner, D. E., Meininger, G. A. & Vatner, S. F., Nov 1 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 9, p. H1281-H1287

New Jersey Institute of Technology, Rutgers, The State University

Research output: Contribution to journalArticle

90 Scopus citations

Metabolomic analysis of two different models of delayed preconditioning

Bravo, C., Kudej, R. K., Yuan, C., Yoon, S., Ge, H., Park, J. Y., Tian, B., Stanley, W. C., Vatner, S. F., Vatner, D. E. & Yan, L., Feb 2013, In : Journal of Molecular and Cellular Cardiology. 55, 1, p. 19-26 8 p.

Rutgers, The State University

Research output: Contribution to journalArticle

8 Scopus citations

Novel mechanisms for caspase inhibition protecting cardiac function with chronic pressure overload

Park, M., Vatner, S. F., Yan, L., Gao, S., Yoon, S., Lee, G. J. A., Xie, L. H., Kitsis, R. N. & Vatner, D. E., 2013, In : Basic research in cardiology. 108, 1, 324.

Rutgers, The State University

Research output: Contribution to journalArticle

14 Scopus citations

Proteomic mechanisms of cardioprotection during Mammalian hibernation in woodchucks, Marmota Monax

Li, H., Liu, T., Chen, W., Jain, M. R., Vatner, D. E., Vatner, S. F., Kudej, R. K. & Yan, L., Sep 6 2013, In : Journal of Proteome Research. 12, 9, p. 4221-4229 9 p.

Rutgers, The State University

Research output: Contribution to journalArticle

7 Scopus citations

Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway

Lai, L., Yan, L., Gao, S., Hu, C. L., Ge, H., Davidow, A., Park, M., Bravo, C., Iwatsubo, K., Ishikawa, Y., Auwerx, J., Sinclair, D. A., Vatner, S. F. & Vatner, D. E., Apr 23 2013, In : Circulation. 127, 16, p. 1692-1701 10 p.

Rutgers, The State University

Research output: Contribution to journalArticle

53 Scopus citations
2012

Cardiomyocyte overexpression of the α 1A-adrenergic receptor in the rat phenocopies second but not first window preconditioning

Zhao, X., Park, J., Ho, D., Gao, S., Yan, L., Ge, H., Iismaa, S., Lin, L., Tian, B., Vatner, D. E., Graham, R. M. & Vatner, S. F., Apr 15 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 302, 8, p. H1614-H1624

Rutgers, The State University

Research output: Contribution to journalArticle

10 Scopus citations

Common mechanisms for calorie restriction and adenylyl cyclase type 5 knockout models of longevity

Yan, L., Park, J. Y., Dillinger, J. G., De Lorenzo, M., Yuan, C., Lai, L., Wang, C., Ho, D., Tian, B., Stanley, W. C., Auwerx, J., Vatner, D. & Vatner, S., Dec 1 2012, In : Aging cell. 11, 6, p. 1110-1120 11 p.

Rutgers, The State University

Research output: Contribution to journalArticle

15 Scopus citations

Prevention of heart failure in mice by an antiviral agent that inhibits type 5 cardiac adenylyl cyclase

Iwatsubo, K., Bravo, C., Uechi, M., Baljinnyam, E., Nakamura, T., Umemura, M., Lai, L., Gao, S., Yan, L., Zhao, X., Park, M., Qiu, H., Okumura, S., Iwatsubo, M., Vatner, D. E., Vatner, S. F. & Ishikawa, Y., Jun 15 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 302, 12, p. 2622-2628 7 p.

Rutgers, The State University

Research output: Contribution to journalArticle

36 Scopus citations

Sexual dimorphism in cardiac triacylglyceride dynamics in mice on long term caloric restriction

Banke, N. H., Yan, L., Pound, K. M., Dhar, S., Reinhardt, H., De Lorenzo, M. S., Vatner, S. F. & Lewandowski, E. D., Mar 1 2012, In : Journal of Molecular and Cellular Cardiology. 52, 3, p. 733-740 8 p.

New Jersey Institute of Technology, Rutgers, The State University

Research output: Contribution to journalArticle

15 Scopus citations

Smooth muscle myosin inhibition: A novel therapeutic approach for pulmonary hypertension

Ho, D., Chen, L., Zhao, X., Durham, N., Pannirselvam, M., Vatner, D. E., Morgans, D. J., Malik, F. I., Vatner, S. F. & Shen, Y. T., May 1 2012, In : PLoS ONE. 7, 5, e36302.

Rutgers, The State University

Research output: Contribution to journalArticle

3 Scopus citations

Temporal analysis of vascular smooth muscle cell elasticity and adhesion reveals oscillation waveforms that differ with aging

Zhu, Y., Qiu, H., Trzeciakowski, J. P., Sun, Z., Li, Z., Hong, Z., Hill, M. A., Hunter, W. C., Vatner, D. E., Vatner, S. F. & Meininger, G. A., Oct 1 2012, In : Aging cell. 11, 5, p. 741-750 10 p.

New Jersey Institute of Technology, Rutgers, The State University

Research output: Contribution to journalArticle

42 Scopus citations
2011
10 Scopus citations

Caloric restriction reduces growth of mammary tumors and metastases

de Lorenzo, M. S., Baljinnyam, E., Vatner, D. E., Abarzúa, P., Vatner, S. F. & Rabson, A. B., 2011, In : Carcinogenesis. 32, 9, p. 1381-1387 7 p.

Rutgers, The State University

Research output: Contribution to journalArticle

58 Scopus citations

Cardiac myosin activation: A potential therapeutic approach for systolic heart failure

Malik, F. I., Hartman, J. J., Elias, K. A., Morgan, B. P., Rodriguez, H., Brejc, K., Anderson, R. L., Sueoka, S. H., Lee, K. H., Finer, J. T., Sakowicz, R., Baliga, R., Cox, D. R., Garard, M., Godinez, G., Kawas, R., Kraynack, E., Lenzi, D., Lu, P. P., Muci, A. & 14 others, Niu, C., Qian, X., Pierce, D. W., Pokrovskii, M., Suehiro, I., Sylvester, S., Tochimoto, T., Valdez, C., Wang, W., Katori, T., Kass, D. A., Shen, Y. T., Vatner, S. F. & Morgans, D. J., Mar 18 2011, In : Science. 331, 6023, p. 1439-1443 5 p.

Rutgers, The State University

Research output: Contribution to journalArticle

265 Scopus citations
43 Scopus citations

H11 kinase/heat shock protein 22 deletion impairs both nuclear and mitochondrial functions of stat3 and accelerates the transition into heart failure on cardiac overload

Qiu, H., Lizano, P., Laure, L., Sui, X., Rashed, E., Park, J. Y., Hong, C., Gao, S., Holle, E., Morin, D., Dhar, S. K., Wagner, T., Berdeaux, A., Tian, B., Vatner, S. F. & Depre, C., Jul 26 2011, In : Circulation. 124, 4, p. 406-415 10 p.

New Jersey Institute of Technology, Rutgers, The State University

Research output: Contribution to journalArticle

65 Scopus citations

Inhibition of smooth muscle myosin as a novel therapeutic target for hypertension

Zhao, X., Ho, D., Abarzúa, P., Dhar, S. K., Wang, X., Jia, Z., Pannirselvam, M., Morgans, D. J., Malik, F. I. & Vatner, S. F., Oct 2011, In : Journal of Pharmacology and Experimental Therapeutics. 339, 1, p. 307-312 6 p.

New Jersey Institute of Technology, Rutgers, The State University

Research output: Contribution to journalArticle

5 Scopus citations
18 Scopus citations

Second window of preconditioning normalizes palmitate use for oxidation and improves function during low-flow ischaemia

Kudej, R. K., Fasano, M., Zhao, X., Lopaschuk, G. D., Fischer, S. K., Vatner, D. E., Vatner, S. F. & Lewandowski, E. D., Dec 1 2011, In : Cardiovascular research. 92, 3, p. 394-400 7 p.

Rutgers, The State University

Research output: Contribution to journalArticle

7 Scopus citations
2010

Design of a miniature tissue culture system to culture mouse heart valves

Lieber, S. C., Kruithof, B. P. T., Aubry, N., Vatner, S. F. & Gaussin, V., Mar 1 2010, In : Annals of Biomedical Engineering. 38, 3, p. 674-682 9 p.

New Jersey Institute of Technology, Rutgers, The State University

Research output: Contribution to journalArticle

4 Scopus citations

Effects of cardiac overexpression of type 6 adenylyl cyclase affects on the response to chronic pressure overload

Guellich, A., Gao, S., Hong, C., Yan, L., Wagner, T. E., Dhar, S. K., Ghaleh, B., Hittinger, L., Iwatsubo, K., Ishikawa, Y., Vatner, S. F. & Vatner, D. E., Sep 2010, In : American Journal of Physiology - Heart and Circulatory Physiology. 299, 3, p. H707-H712

New Jersey Institute of Technology, Rutgers, The State University

Research output: Contribution to journalArticle

18 Scopus citations

Improvement of cardiac function by a cardiac myosin activator in conscious dogs with systolic heart failure

Shen, Y. T., Malik, F. I., Zhao, X., Depre, C., Dhar, S. K., Abarzúa, P., Morgans, D. J. & Vatner, S. F., Jul 1 2010, In : Circulation: Heart Failure. 3, 4, p. 522-527 6 p.

New Jersey Institute of Technology, Rutgers, The State University

Research output: Contribution to journalArticle

98 Scopus citations
29 Scopus citations
13 Scopus citations

Short communication: Vascular smooth muscle cell stiffness as a mechanism for increased aortic stiffness with aging

Qiu, H., Zhu, Y., Sun, Z., Trzeciakowski, J. P., Gansner, M., Depre, C., Resuello, R. R. G., Natividad, F. F., Hunter, W. C., Genin, G. M., Elson, E. L., Vatner, D. E., Meininger, G. A. & Vatner, S. F., Sep 3 2010, In : Circulation research. 107, 5, p. 615-619 5 p.

New Jersey Institute of Technology, Rutgers, The State University

Research output: Contribution to journalArticle

178 Scopus citations