Thomas Keck

Rowan University

    • 412 Citations
    • 13 h-Index
    20062020

    Research output per year

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    Personal profile

    Research interests

    Research Expertise:
    Pharmacology | Neuroscience | Biochemistry

    I am interested in developing new medications for neuropsychiatric disorders, including Alzheimer’s disease, schizophrenia, ADHD, pain, anxiety, and a particular interest in drug addiction. My lab works closely with medicinal chemists to design and test new drug-like molecules, combining molecular and behavioral pharmacology methods to evaluate the preclinical potential of new compounds designed to target the dopamine D4 receptor, the µ opioid receptor, and the trace amine-associated receptor 1, among others.

    Honors and Awards:
    2017 Maharaj Ticku Memorial Travel Fellowship for New Investigators Award, Behavior, Biology and Chemistry Conf.
    2015 Frances R. Lax Faculty Development Award, Rowan University
    2013 Mentoring Award for Fellows, NIDA-IRP, NIH
    2013 Postdoctoral Mentor Award, NIH
    2012 & 2013 Fellows’ Award for Research Excellence, NIH

    Member of:
    American Society for Pharmacology and Experimental Therapeutics https://www.aspet.org/
    Pharmacology Society (Councilor) https://www.aspet.org/MAPS/
    Philadelphia Chapter of the Society for Neuroscience http://pcsfn.com/

    Education/Academic qualification

    Doctor of Philosophy, doctorate

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    Projects

    Research Output

    • 412 Citations
    • 13 h-Index
    • 22 Article
    • 1 Chapter

    Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist

    Moritz, A. E., Free, R. B., Weiner, W. S., Akano, E. O., Gandhi, D., Abramyan, A., Keck, T. M., Ferrer, M., Hu, X., Southall, N., Steiner, J., Aubé, J., Shi, L., Frankowski, K. J. & Sibley, D. R., May 28 2020, In : Journal of medicinal chemistry. 63, 10, p. 5526-5567 42 p.

    Rowan University

    Research output: Contribution to journalArticle

  • Neurochemical and behavioral comparisons of contingent and non-contingent methamphetamine exposure following binge or yoked long-access self-administration paradigms

    Schweppe, C. A., Burzynski, C., Jayanthi, S., Ladenheim, B., Cadet, J. L., Gardner, E. L., Xi, Z. X., van Praag, H., Newman, A. H. & Keck, T. M., Jan 1 2020, (Accepted/In press) In : Psychopharmacology.

    Rowan University

    Research output: Contribution to journalArticle

  • Cognitive and behavioral effects of brief seizures in mice

    Batterman, A. I., DeChiara, J., Islam, A., Brenner, M. B., Fischer, B. D., Buono, R. J., Keck, T. & Ferraro, T., Sep 1 2019, In : Epilepsy and Behavior. 98, p. 249-257 9 p.

    Rowan University

    Research output: Contribution to journalArticle

  • Dopamine D4 Receptor-Selective Compounds Reveal Structure-Activity Relationships that Engender Agonist Efficacy

    Keck, T. M., Free, R. B., Day, M. M., Brown, S. L., Maddaluna, M. S., Fountain, G., Cooper, C., Fallon, B., Holmes, M., Stang, C. T., Burkhardt, R., Bonifazi, A., Ellenberger, M. P., Newman, A. H., Sibley, D. R., Wu, C. & Boateng, C. A., Apr 11 2019, In : Journal of medicinal chemistry. 62, 7, p. 3722-3740 19 p.

    Rowan University

    Research output: Contribution to journalArticle

    Open Access
  • 5 Scopus citations

    Multitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia

    Del Bello, F., Ambrosini, D., Bonifazi, A., Newman, A. H., Keck, T. M., Giannella, M., Giorgioni, G., Piergentili, A., Cappellacci, L., Cilia, A., Franchini, S. & Quaglia, W., May 15 2019, In : ACS chemical neuroscience. 10, 5, p. 2222-2228 7 p.

    Rowan University

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Press / Media

    Government-Owned Inventions; Availability for Licensing

    Thomas Keck

    11/20/13

    1 item of Media coverage

    Rowan University

    Press/Media: Press / Media