Projects per year
Personal profile
Research interests
Research Expertise:
Pharmacology | Neuroscience | Biochemistry
I am interested in developing new medications for neuropsychiatric disorders, including Alzheimer’s disease, schizophrenia, ADHD, pain, anxiety, and a particular interest in drug addiction. My lab works closely with medicinal chemists to design and test new drug-like molecules, combining molecular and behavioral pharmacology methods to evaluate the preclinical potential of new compounds designed to target the dopamine D4 receptor, the µ opioid receptor, and the trace amine-associated receptor 1, among others.
Honors and Awards:
2017 Maharaj Ticku Memorial Travel Fellowship for New Investigators Award, Behavior, Biology and Chemistry Conf.
2015 Frances R. Lax Faculty Development Award, Rowan University
2013 Mentoring Award for Fellows, NIDA-IRP, NIH
2013 Postdoctoral Mentor Award, NIH
2012 & 2013 Fellows’ Award for Research Excellence, NIH
Member of:
American Society for Pharmacology and Experimental Therapeutics https://www.aspet.org/
Pharmacology Society (Councilor) https://www.aspet.org/MAPS/
Philadelphia Chapter of the Society for Neuroscience http://pcsfn.com/
Education/Academic qualification
Doctor of Philosophy, doctorate
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Negative allosteric modulators of the D3 dopamine receptor as therapeutic leads for substance use disorders
6/1/22 → 4/30/23
Project: Other project
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Analgesia without Addiction: Synthesis and Development of 2nd Generation Novel Analgesics
Foundation for Health Advancement
3/2/22 → 2/28/23
Project: Other project
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Low-Efficacy Dopamine D4 Receptor Partial Agonists for Cocaine Addiction
9/30/20 → 8/31/22
Project: Other project
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Analgesia without Addiction: Synthesis and Development of Highly Selective Novel Analgesics
New Jersey Health Foundation, Inc.
2/15/19 → 2/27/20
Project: Other project
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Decoding brain memory formation by single-cell RNA sequencing
Sardoo, A. M., Zhang, S., Ferraro, T. N., Keck, T. M. & Chen, Y., Nov 19 2022, In: Briefings in Bioinformatics. 23, 6Research output: Contribution to journal › Article › peer-review
Open Access -
Functional and pharmacological role of the dopamine D4 receptor and its polymorphic variants
Ferré, S., Belcher, A. M., Bonaventura, J., Quiroz, C., Sánchez-Soto, M., Casadó-Anguera, V., Cai, N. S., Moreno, E., Boateng, C. A., Keck, T. M., Florán, B., Earley, C. J., Ciruela, F., Casadó, V., Rubinstein, M. & Volkow, N. D., Sep 30 2022, In: Frontiers in Endocrinology. 13, 1014678.Research output: Contribution to journal › Review article › peer-review
Open Access -
Scaffold Hybridization Strategy Leads to the Discovery of Dopamine D3Receptor-Selective or Multitarget Bitopic Ligands Potentially Useful for Central Nervous System Disorders
Bonifazi, A., Newman, A. H., Keck, T. M., Gervasoni, S., Vistoli, G., Del Bello, F., Giorgioni, G., Pavletić, P., Quaglia, W. & Piergentili, A., Oct 6 2021, In: ACS Chemical Neuroscience. 12, 19, p. 3638-3649 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Synergistic antihyperalgesic and antinociceptive effects of morphine and methyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate (MP-III-024): a positive allosteric modulator at α2GABAA and α3GABAA receptors
Rahman, M. A., Keck, T. M., Poe, M. M., Sharmin, D., Cook, J. M. & Fischer, B. D., Jun 2021, In: Psychopharmacology. 238, 6, p. 1585-1592 8 p.Research output: Contribution to journal › Article › peer-review
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Abuse Liability, Anti-Nociceptive, and Discriminative Stimulus Properties of IBNtxA
Islam, A., Rahman, M. A., Brenner, M. B., Moore, A., Kellmyer, A., Buechler, H. M., Digiorgio, F., Verchio, V. R., McCracken, L., Sumi, M., Hartley, R., Lizza, J. R., Moura-Letts, G., Fischer, B. D. & Keck, T. M., Oct 9 2020, In: ACS Pharmacology and Translational Science. 3, 5, p. 907-920 14 p.Research output: Contribution to journal › Article › peer-review