Thomas Keck

Rowan University

    • 392 Citations
    • 13 h-Index
    20062020

    Research output per year

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    Research Output

    • 392 Citations
    • 13 h-Index
    • 20 Article
    • 1 Chapter
    2019

    Cognitive and behavioral effects of brief seizures in mice

    Batterman, A. I., DeChiara, J., Islam, A., Brenner, M. B., Fischer, B. D., Buono, R. J., Keck, T. & Ferraro, T., Sep 1 2019, In : Epilepsy and Behavior. 98, p. 249-257 9 p.

    Rowan University

    Research output: Contribution to journalArticle

    Dopamine D4 Receptor-Selective Compounds Reveal Structure-Activity Relationships that Engender Agonist Efficacy

    Keck, T. M., Free, R. B., Day, M. M., Brown, S. L., Maddaluna, M. S., Fountain, G., Cooper, C., Fallon, B., Holmes, M., Stang, C. T., Burkhardt, R., Bonifazi, A., Ellenberger, M. P., Newman, A. H., Sibley, D. R., Wu, C. & Boateng, C. A., Apr 11 2019, In : Journal of medicinal chemistry. 62, 7, p. 3722-3740 19 p.

    Rowan University

    Research output: Contribution to journalArticle

    Open Access
    4 Scopus citations

    Multitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia

    Del Bello, F., Ambrosini, D., Bonifazi, A., Newman, A. H., Keck, T. M., Giannella, M., Giorgioni, G., Piergentili, A., Cappellacci, L., Cilia, A., Franchini, S. & Quaglia, W., May 15 2019, In : ACS chemical neuroscience. 10, 5, p. 2222-2228 7 p.

    Rowan University

    Research output: Contribution to journalArticle

    3 Scopus citations
    2017

    Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D3 Receptor (D3R)

    Kumar, V., Moritz, A. E., Keck, T. M., Bonifazi, A., Ellenberger, M. P., Sibley, C. D., Free, R. B., Shi, L., Lane, J. R., Sibley, D. R. & Newman, A. H., Feb 23 2017, In : Journal of medicinal chemistry. 60, 4, p. 1478-1494 17 p.

    Rowan University

    Research output: Contribution to journalArticle

    19 Scopus citations

    The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT1Areceptor over α1-adrenoceptor and D2-like receptor subtypes

    Del Bello, F., Bonifazi, A., Giannella, M., Giorgioni, G., Piergentili, A., Petrelli, R., Cifani, C., Micioni Di Bonaventura, M. V., Keck, T. M., Mazzolari, A., Vistoli, G., Cilia, A., Poggesi, E., Matucci, R. & Quaglia, W., Jan 1 2017, In : European Journal of Medicinal Chemistry. 125, p. 233-244 12 p.

    Rowan University

    Research output: Contribution to journalArticle

    9 Scopus citations

    Toward understanding the structural basis of partial agonism at the dopamine D3 receptor

    Michino, M., Boateng, C. A., Donthamsetti, P., Yano, H., Bakare, O. M., Bonifazi, A., Ellenberger, M. P., Keck, T. M., Kumar, V., Zhu, C., Verma, R., Deschamps, J. R., Javitch, J. A., Newman, A. H. & Shi, L., Jan 26 2017, In : Journal of medicinal chemistry. 60, 2, p. 580-593 14 p.

    Rowan University

    Research output: Contribution to journalArticle

    16 Scopus citations
    2016

    A Novel Class of Dopamine D4Receptor Ligands Bearing an Imidazoline Nucleus

    Mammoli, V., Bonifazi, A., Dal Ben, D., Giannella, M., Giorgioni, G., Piergentili, A., Pigini, M., Quaglia, W., Thomas, A., Newman, A. H., Ferré, S., Sanchez-Soto, M., Keck, T. M. & Del Bello, F., Jan 1 2016, In : ChemMedChem. p. 1819-1828 10 p.

    Rowan University

    Research output: Contribution to journalArticle

    4 Scopus citations

    Highly selective dopamine D3 receptor (D3R) antagonists and partial agonists based on eticlopride and the D3R crystal structure: New leads for opioid dependence treatment

    Kumar, V., Bonifazi, A., Ellenberger, M. P., Keck, T. M., Pommier, E., Rais, R., Slusher, B. S., Gardner, E., You, Z. B., Xi, Z. X. & Newman, A. H., Aug 25 2016, In : Journal of medicinal chemistry. 59, 16, p. 7634-7650 17 p.

    Rowan University

    Research output: Contribution to journalArticle

    27 Scopus citations

    Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity

    Zou, M. F., Keck, T. M., Kumar, V., Donthamsetti, P., Michino, M., Burzynski, C., Schweppe, C., Bonifazi, A., Free, R. B., Sibley, D. R., Janowsky, A., Shi, L., Javitch, J. A. & Newman, A. H., Apr 28 2016, In : Journal of medicinal chemistry. 59, 7, p. 2973-2988 16 p.

    Rowan University

    Research output: Contribution to journalArticle

    13 Scopus citations
    2015

    High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice

    Boateng, C. A., Bakare, O. M., Zhan, J., Banala, A. K., Burzynski, C., Pommier, E., Keck, T. M., Donthamsetti, P., Javitch, J. A., Rais, R., Slusher, B. S., Xi, Z. X. & Newman, A. H., Jul 23 2015, In : Journal of medicinal chemistry. 58, 15, p. 6195-6213 19 p.

    Rowan University

    Research output: Contribution to journalArticle

    27 Scopus citations

    Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis

    Keck, T. M., John, W. S., Czoty, P. W., Nader, M. A. & Newman, A. H., Jul 23 2015, In : Journal of medicinal chemistry. 58, 14, p. 5361-5380 20 p.

    Rowan University

    Research output: Contribution to journalArticle

    49 Scopus citations

    Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands

    Keck, T. M., Banala, A. K., Slack, R. D., Burzynski, C., Bonifazi, A., Okunola-Bakare, O. M., Moore, M., Deschamps, J. R., Rais, R., Slusher, B. S. & Newman, A. H., Jun 11 2015, In : Bioorganic and Medicinal Chemistry. 23, 14, p. 4000-4012 13 p.

    Rowan University

    Research output: Contribution to journalArticle

    17 Scopus citations
    2014

    A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats

    Keck, T. M., Zou, M. F., Bi, G. H., Zhang, H. Y., Wang, X. F., Yang, H. J., Srivastava, R., Gardner, E. L., Xi, Z. X. & Newman, A. H., Mar 1 2014, In : Addiction Biology. 19, 2, p. 195-209 15 p.

    Rowan University

    Research output: Contribution to journalArticle

    17 Scopus citations

    Beyond small-molecule sar: Using the dopamine d3 receptor crystal structure to guide drug design

    Keck, T. M., Burzynski, C., Shi, L. & Newman, A. H., 2014, Advances in Pharmacology. Academic Press Inc., p. 267-300 34 p. (Advances in Pharmacology; vol. 69).

    Rowan University

    Research output: Chapter in Book/Report/Conference proceedingChapter

    26 Scopus citations

    Chiral resolution and serendipitous fluorination reaction for the selective dopamine d3 receptor antagonist BAK2-66

    Kumar, V., Banala, A. K., Garcia, E. G., Cao, J., Keck, T. M., Bonifazi, A., Deschamps, J. R. & Newman, A. H., Jun 12 2014, In : ACS Medicinal Chemistry Letters. 5, 6, p. 647-651 5 p.

    Rowan University

    Research output: Contribution to journalArticle

    11 Scopus citations

    Tranylcypromine substituted cis -hydroxycyclobutylnaphthamides as potent and selective dopamine D3 receptor antagonists

    Chen, J., Levant, B., Jiang, C., Keck, T. M., Newman, A. H. & Wang, S., Jun 12 2014, In : Journal of medicinal chemistry. 57, 11, p. 4962-4968 7 p.

    Rowan University

    Research output: Contribution to journalArticle

    25 Scopus citations
    2013

    Dopamine D4 receptor deficiency in mice alters behavioral responses to anxiogenic stimuli and the psychostimulant methylphenidate

    Keck, T. M., Suchland, K. L., Jimenez, C. C. & Grandy, D. K., Feb 1 2013, In : Pharmacology Biochemistry and Behavior. 103, 4, p. 831-841 11 p.

    Rowan University

    Research output: Contribution to journalArticle

    17 Scopus citations

    Fenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: Implications for addiction treatment in humans

    Keck, T. M., Yang, H. J., Bi, G. H., Huang, Y., Zhang, H. Y., Srivastava, R., Gardner, E. L., Newman, A. H. & Xi, Z. X., Sep 1 2013, In : Psychopharmacology. 229, 2, p. 253-265 13 p.

    Rowan University

    Research output: Contribution to journalArticle

    19 Scopus citations
    2012

    Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation

    Keck, T. M., Zou, M. F., Zhang, P., Rutledge, R. P. & Newman, A. H., Jul 12 2012, In : ACS Medicinal Chemistry Letters. 3, 7, p. 544-549 6 p.

    Rowan University

    Research output: Contribution to journalArticle

    9 Scopus citations
    2006

    Interferon regulatory factor 3 is necessary for induction of antiviral genes during human cytomegalovirus infection

    DeFilippis, V. R., Robinson, B., Keck, T. M., Hansen, S. G., Nelson, J. A. & Früh, K. J., Jan 1 2006, In : Journal of virology. 80, 2, p. 1032-1037 6 p.

    Rowan University

    Research output: Contribution to journalArticle

    50 Scopus citations

    K+ channel KV3.1 associates with OSP/claudin-11 and regulates oligodendrocyte development

    Tiwari-Woodruff, S., Beltran-Parrazal, L., Charles, A., Keck, T., Vu, T. & Bronstein, J., Oct 9 2006, In : American Journal of Physiology - Cell Physiology. 291, 4, p. C687-C698

    Rowan University

    Research output: Contribution to journalArticle

    30 Scopus citations