Projects per year
Personal profile
Research interests
Research Expertise:
Physical Chemistry | Biophysical Chemistry | Spectroscopy
My research utilizes tools of experimental physical chemistry to investigate metal ion-molecule interactions, characterize the proton solvation and conduction mechanisms in ionic liquid solutions, and protein stability in aqueous ionic liquids.
My lab has four main research projects underway:
Characterizing the solvation of protons in ionic liquids and the proton transportation mechanisms in acidic ionic liquid solutions.
Understanding the behavior of proteins and antibiotics in aqueous ionic liquid solutions.
Evaluating competitive metal ion chelation by small molecules in the presence of peptides.
Synthesizing and evaluating different hydrogen-generating electrocatalysts.
Member of:
American Chemical Society (www.acs.org)
Recent Academic Projects:
Investigations of TMG-biomolecule ILs for stabilizing proteins, investigations of ILs for enhancing antibiotic activities
Education/Academic qualification
Doctor of Philosophy, doctorate
Bachelor of Science, Bachelor
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Projects
- 1 Finished
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RUI: Combining experiments and simulations to optimize biomolecular ionic liquids for protein stabilization
Vaden, T. (PI)
National Science Foundation (NSF)
8/15/19 → 7/31/23
Project: Other project
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Ion-DNA Interactions as a Key Determinant of Uracil DNA Glycosylase Activity
Greenwood, S. N., Dispensa, A. N., Wang, M., Bauer, J. R., Vaden, T. D., Liu, Z. & Weiser, B., May 20 2025, In: Biochemistry. 64, 10, p. 2332-2344 13 p.Research output: Contribution to journal › Article › peer-review
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Lipid bilayer permeabilities and antibiotic effects of tetramethylguanidinium and choline fatty acid ionic liquids
Dutta, A., Burrell, B., Prajapati, E., Cottle, S., Maurer, H. Y., Urban, M. J., Pennock, S. R., Muhamed, A. M., Harris, J., Flores, Y., Staman, L., Carone, B. R., Caputo, G. A. & Vaden, T. D., Jan 2025, In: Biochimica et Biophysica Acta - Biomembranes. 1867, 1, 184393.Research output: Contribution to journal › Article › peer-review
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Elucidating the stabilization mechanism of a K+-depleted c-MYC DNA G-quadruplex in hydrophobic imidazolium-based ionic liquids using spectroscopy coupled with molecular dynamics simulations
Paradis, N. J., Clark, A., Dutta, A., Gogoj, H., Vaden, T. D. & Wu, C., Apr 2024, In: Journal of Molecular Liquids. 399, 124407.Research output: Contribution to journal › Article › peer-review
Open Access -
Critical Sites on Ostreolysin Are Responsible for Interaction with Cytoskeletal Proteins
Berke, N. A., Di Pizio, A., Vaden, T. D., Shoval, I., Gover, O., Waiger, D., Solomon, G., Sepčić, K. & Schwartz, B., Oct 2022, In: Biomedicines. 10, 10, 2442.Research output: Contribution to journal › Article › peer-review
Open Access -
Sequence-specific destabilization of azurin by tetramethylguanidinium-dipeptide ionic liquids
Patel, R., Clark, A. K., DeStefano, G., DeStefano, I., Gogoj, H., Gray, E., Patel, A. Y., Hauner, J. T., Caputo, G. A. & Vaden, T. D., Jul 2022, In: Biochemistry and Biophysics Reports. 30, 101242.Research output: Contribution to journal › Article › peer-review
Open Access