Xiaoyang Su

2024

Leukemia inhibitory factor suppresses hepatic de novo lipogenesis and induces cachexia in mice

Yang, X., Wang, J., Chang, C. Y., Zhou, F., Liu, J., Xu, H., Ibrahim, M., Gomez, M., Guo, G. L., Liu, H., Zong, W. X., Wondisford, F. E., Su, X., White, E., Feng, Z. & Hu, W., Dec 2024, In: Nature communications. 15, 1, 627.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

2023

A Therapeutically Targetable NOTCH1–SIRT1–KAT7 Axis in T-cell Leukemia

Lancho, O., Singh, A., da Silva-Diz, V., Aleksandrova, M., Khatun, J., Tottone, L., Nunes, P. R., Luo, S., Zhao, C., Zheng, H., Chiles, E., Zuo, Z., Rocha, P. P., Su, X., Khiabanian, H. & Herranz, D., Jan 1 2023, In: Blood cancer discovery. 4, 1, p. 13-33 21 p.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Histone deacetylase inhibitor belinostat regulates metabolic reprogramming in killing KRAS-mutant human lung cancer cells

Peter, R. M., Sarwar, M. S., Mostafa, S. Z., Wang, Y., Su, X. & Kong, A. N., Aug 2023, In: Molecular Carcinogenesis. 62, 8, p. 1136-1146 11 p.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Inhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors

Bhatt, V., Lan, T., Wang, W., Kong, J., Lopes, E. C., Wang, J., Khayati, K., Raju, A., Rangel, M., Lopez, E., Hu, Z. S., Luo, X., Su, X., Malhotra, J., Hu, W., White, E. & Guo, J. Y., Jan 2023, In: Cell Death and Disease. 14, 1, 61.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

Linking genotypic and phenotypic changes in the E. coli long-term evolution experiment using metabolomics

Favate, J. S., Skalenko, K. S., Chiles, E., Su, X., Yadavalli, S. S. & Shah, P., 2023, In: eLife. 12, RP87039.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

Metabolic rewiring and epigenetic reprogramming in leptin receptor-deficient db/db diabetic nephropathy mice

Sarwar, M. S., Cheng, D., Peter, R. M., Shannar, A., Chou, P., Wang, L., Wu, R., Sargsyan, D., Goedken, M., Wang, Y., Su, X., Hart, R. P. & Kong, A.-N., Aug 15 2023, In: European Journal of Pharmacology. 953, p. 175866

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Metabolomic, DNA Methylomic, and Transcriptomic Profiling of Suberoylanilide Hydroxamic Acid Effects on LPS-Exposed Lung Epithelial Cells

Chou, P. J., Sarwar, M. S., Wang, L., Wu, R., Li, S., Hudlikar, R. R., Wang, Y., Su, X. & Kong, A. N., Jun 1 2023, In: Cancer Prevention Research. 16, 6, p. 321-332 12 p.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

Netrin-1 feedforward mechanism promotes pancreatic cancer liver metastasis via hepatic stellate cell activation, retinoid, and ELF3 signaling

Dudgeon, C., Casabianca, A., Harris, C., Ogier, C., Bellina, M., Fiore, S., Bernet, A., Ducarouoge, B., Goldschneider, D., Su, X., Pitarresi, J., Hezel, A., De, S., Narrow, W., Soliman, F., Shields, C., Vendramini-Costa, D. B., Prela, O., Wang, L. & Astsaturov, I. & 1 others, Mehlen, P., Nov 28 2023, In: Cell Reports. 42, 11, 113369.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1

Zhao, Y., Liu, Z., Liu, G., Zhang, Y., Liu, S., Gan, D., Chang, W., Peng, X., Sung, E. S., Gilbert, K., Zhu, Y., Wang, X., Zeng, Z., Baldwin, H., Ren, G., Weaver, J., Huron, A., Mayberry, T., Wang, Q. & Wang, Y. & 10 others, Diaz-Rubio, M. E., Su, X., Stack, M. S., Zhang, S., Lu, X., Sheldon, R. D., Li, J., Zhang, C., Wan, J. & Lu, X., Oct 3 2023, In: Cell Metabolism. 35, 10, p. 1688-1703.e10

Research output: Contribution to journal › Article › peer-review

Profiles of Semi-Polar Metabolites from Leaves of In Vitro- Derived Plants of Indonesian Pepper Varieties (Capsicum annuum) after Gamma Irradiation Treatments

Wahyuni, Sri Hartati, N., Sulistyowati, Y., Perdani, A. Y., Roziqoh, W., Farias-Pereira, R., Su, X., Sudarmonowati, E. & Raskin, I., 2023, In: IOP Conference Series: Earth and Environmental Science. 1255, 1, 012057.

Rutgers, The State University

Research output: Contribution to journal › Conference article › peer-review

Open Access

The environmental carcinogen benzo[a]pyrene regulates epigenetic reprogramming and metabolic rewiring in a two-stage mouse skin carcinogenesis model

Sarwar, M. S., Ramirez, C. N., Dina Kuo, H. C., Chou, P., Wu, R., Sargsyan, D., Yang, Y., Shannar, A., Mary Peter, R., Yin, R., Wang, Y., Su, X. & Kong, A. N., May 1 2023, In: Carcinogenesis. 44, 5, p. 436-449 14 p.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

2022

Butyrate Drives Metabolic Rewiring and Epigenetic Reprogramming in Human Colon Cancer Cells

Wang, L., Shannar, A. A. F., Wu, R., Chou, P., Sarwar, M. S., Kuo, H. C., Peter, R. M., Wang, Y., Su, X. & Kong, A. N., Jun 2022, In: Molecular Nutrition and Food Research. 66, 12, 2200028.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

Development of a portable toolkit to diagnose coral thermal stress

Meng, Z., Williams, A., Liau, P., Stephens, T. G., Drury, C., Chiles, E. N., Su, X., Javanmard, M. & Bhattacharya, D., Dec 2022, In: Scientific reports. 12, 1, 14398.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

Dietary glucosamine overcomes the defects in αβ-T cell ontogeny caused by the loss of de novo hexosamine biosynthesis

Werlen, G., Li, M. L., Tottone, L., da Silva-Diz, V., Su, X., Herranz, D. & Jacinto, E., Dec 2022, In: Nature communications. 13, 1, 7404.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

Global stable-isotope tracing metabolomics reveals system-wide metabolic alternations in aging Drosophila

Wang, R., Yin, Y., Li, J., Wang, H., Lv, W., Gao, Y., Wang, T., Zhong, Y., Zhou, Z., Cai, Y., Su, X., Liu, N. & Zhu, Z. J., Dec 2022, In: Nature communications. 13, 1, 3518.

Research output: Contribution to journal › Article › peer-review

Open Access

Glucagon changes substrate preference in gluconeogenesis

Xu, H., Wang, Y., Kwon, H., Shah, A., Kalemba, K., Su, X., He, L. & Wondisford, F. E., Dec 2022, In: Journal of Biological Chemistry. 298, 12, 102708.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

Glutamine synthetase limits β-catenin-mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1

Dai, W., Shen, J., Yan, J., Bott, A. J., Maimouni, S., Daguplo, H. Q., Wang, Y., Khayati, K., Guo, J. Y., Zhang, L., Wang, Y., Valvezan, A., Ding, W. X., Chen, X., Su, X., Gao, S. & Zong, W. X., Dec 15 2022, In: Journal of Clinical Investigation. 132, 24, e161408.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance

Wu, Y., Wong, C. W., Chiles, E. N., Mellinger, A. L., Bae, H., Jung, S., Peterson, T., Wang, J., Negrete, M., Huang, Q., Wang, L., Jang, C., Muddiman, D. C., Su, X., Williamson, I. & Shen, X., Jul 5 2022, In: Cell Metabolism. 34, 7, p. 1042-1053.e6

Research output: Contribution to journal › Article › peer-review

Open Access

Glycerol's contribution to lactate production outside of a glucose intermediate in fasting humans

Shah, A., Wang, Y., Su, X. & Wondisford, F. E., Jul 2022, In: Metabolism: Clinical and Experimental. 132, 155214.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Leukemia inhibitory factor drives glucose metabolic reprogramming to promote breast tumorigenesis

Yue, X., Wang, J., Chang, C. Y., Liu, J., Yang, X., Zhou, F., Qiu, X., Bhatt, V., Guo, J. Y., Su, X., Zhang, L., Feng, Z. & Hu, W., Apr 2022, In: Cell Death and Disease. 13, 4, 370.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

mTOR regulates aerobic glycolysis through NEAT1 and nuclear paraspeckle-mediated mechanism in hepatocellular carcinoma

Zhang, H., Su, X., Burley, S. K. & Steven Zheng, X. F., 2022, In: Theranostics. 12, 8, p. 3518-3533 16 p.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

Nfe2l2 Regulates Metabolic Rewiring and Epigenetic Reprogramming in Mediating Cancer Protective Effect by Fucoxanthin

Wang, L., Wu, R., Sargsyan, D., Su, S., Kuo, H. C., Li, S., Chou, P., Sarwar, M. S., Phadnis, A., Wang, Y., Su, X. & Kong, A. N., Feb 2022, In: AAPS Journal. 24, 1, 30.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Nuclear SOD1 in Growth Control, Oxidative Stress Response, Amyotrophic Lateral Sclerosis, and Cancer

Xu, J., Su, X., Burley, S. K. & Zheng, X. F. S., Feb 2022, In: Antioxidants. 11, 2, 427.

Rutgers, The State University

Research output: Contribution to journal › Review article › peer-review

Open Access

PTEN-knockout regulates metabolic rewiring and epigenetic reprogramming in prostate cancer and chemoprevention by triterpenoid ursolic acid

Wang, L., Wang, C., Sarwar, M. S., Chou, P., Wang, Y., Su, X. & Kong, A. N. T., Nov 2022, In: FASEB Journal. 36, 11, e22626.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

Stable isotope tracing reveals compartmentalized nitrogen assimilation in scleractinian corals

Chiles, E. N., Huffmyer, A. S., Drury, C., Putnam, H. M., Bhattacharya, D. & Su, X., Nov 28 2022, In: Frontiers in Marine Science. 9, 1035523.

Research output: Contribution to journal › Article › peer-review

Open Access

Tobacco carcinogen 4-[methyl(nitroso)amino]-1-(3-pyridinyl)-1-butanone (NNK) drives metabolic rewiring and epigenetic reprograming in A/J mice lung cancer model and prevention with diallyl sulphide (DAS)

Hudlikar, R. R., Sargsyan, D., Cheng, D., Kuo, H. C. D., Wu, R., Su, X. & Kong, A. N., Feb 1 2022, In: Carcinogenesis. 43, 2, p. 140-149 10 p.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

Triterpenoid ursolic acid drives metabolic rewiring and epigenetic reprogramming in treatment/prevention of human prostate cancer

Li, S., Wu, R., Wang, L., Dina Kuo, H. C., Sargsyan, D., Zheng, X., Wang, Y., Su, X. & Kong, A. N., Jan 2022, In: Molecular Carcinogenesis. 61, 1, p. 111-121 11 p.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

2021

AccuCor2: isotope natural abundance correction for dual-isotope tracer experiments

Wang, Y., Parsons, L. R. & Su, X., Oct 2021, In: Laboratory Investigation. 101, 10, p. 1403-1410 8 p.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

A novel and highly effective mitochondrial uncoupling drug in T-cell leukemia

da Silva-Diz, V., Cao, B., Lancho, O., Chiles, E., Alasadi, A., Aleksandrova, M., Luo, S., Singh, A., Tao, H., Augeri, D., Minuzzo, S., Indraccolo, S., Khiabanian, H., Su, X., Jin, S. & Herranz, D., Oct 14 2021, In: Blood. 138, 15, p. 1317-1330 14 p.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

Lactobacillus rhamnosus GG modifies the metabolome of pathobionts in gnotobiotic mice

Kim, J., Balasubramanian, I., Bandyopadhyay, S., Nadler, I., Singh, R., Harlan, D., Bumber, A., He, Y., Kerkhof, L. J., Gao, N., Su, X. & Ferraris, R. P., Dec 2021, In: BMC Microbiology. 21, 1, 165.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

Local production of lactate, ribose phosphate, and amino acids by human triple-negative breast cancer

Ghergurovich, J. M., Lang, J. D., Levin, M. K., Briones, N., Facista, S. J., Mueller, C., Cowan, A. J., McBride, M. J., San Roman Rodriguez, E., Killian, A., Dao, T., Lamont, J., Barron, A., Su, X., Hendricks, W. P. D., Espina, V., Von Hoff, D. D., O'Shaughnessy, J. & Rabinowitz, J. D., Jun 11 2021, In: Med. 2, 6, p. 736-754.e6

Princeton University, Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

Metabolomic shifts associated with heat stress in coral holobionts

Williams, A., Chiles, E. N., Conetta, D., Pathmanathan, J. S., Cleves, P. A., Putnam, H. M., Su, X. & Bhattacharya, D., Jan 1 2021, In: Science advances. 7, 1, eabd4210.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Mitochondrial inhibitors circumvent adaptive resistance to venetoclax and cytarabine combination therapy in acute myeloid leukemia

Bosc, C., Saland, E., Bousard, A., Gadaud, N., Sabatier, M., Cognet, G., Farge, T., Boet, E., Gotanègre, M., Aroua, N., Mouchel, P. L., Polley, N., Larrue, C., Kaphan, E., Picard, M., Sahal, A., Jarrou, L., Tosolini, M., Rambow, F. & Cabon, F. & 20 others, Nicot, N., Poillet-Perez, L., Wang, Y., Su, X., Fovez, Q., Kluza, J., Argüello, R. J., Mazzotti, C., Avet-Loiseau, H., Vergez, F., Tamburini, J., Fournié, J. J., Tiong, I. S., Wei, A. H., Kaoma, T., Marine, J. C., Récher, C., Stuani, L., Joffre, C. & Sarry, J. E., Nov 2021, In: Nature Cancer. 2, 11, p. 1204-1223 20 p.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Mitochondrial uncoupler MB1-47 is efficacious in treating hepatic metastasis of pancreatic cancer in murine tumor transplantation models

Alasadi, A., Cao, B., Guo, J., Tao, H., Collantes, J., Tan, V., Su, X., Augeri, D. & Jin, S., Mar 25 2021, In: Oncogene. 40, 12, p. 2285-2295 11 p.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Multi-omic characterization of the thermal stress phenome in the stony coral Montipora capitata

Williams, A., Pathmanathan, J. S., Stephens, T. G., Su, X., Chiles, E. N., Conetta, D., Putnam, H. M. & Bhattacharya, D., Nov 2021, In: PeerJ. 9, e12335.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

Mycobacterium tuberculosis VapC4 toxin engages small ORFs to initiate an integrated oxidative and copper stress response

Barth, V. C., Chauhan, U., Zeng, J., Su, X., Zheng, H., Husson, R. N. & Woychik, N. A., Aug 10 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 32, e2022136118.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

NAD⁺ flux is maintained in aged mice despite lower tissue concentrations

McReynolds, M. R., Chellappa, K., Chiles, E., Jankowski, C., Shen, Y., Chen, L., Descamps, H. C., Mukherjee, S., Bhat, Y. R., Lingala, S. R., Chu, Q., Botolin, P., Hayat, F., Doke, T., Susztak, K., Thaiss, C. A., Lu, W., Migaud, M. E., Su, X. & Rabinowitz, J. D. & 1 others, Baur, J. A., Dec 15 2021, In: Cell Systems. 12, 12, p. 1160-1172.e4

Princeton University, Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

Oncogenic Integration of Nucleotide Metabolism via Fatty Acid Synthase in Non-Hodgkin Lymphoma

Ravi, D., Beheshti, A., Abermil, N., Lansigan, F., Kinlaw, W., Matthan, N. R., Mokhtar, M., Passero, F. C., Puliti, P., David, K. A., Dolnikowski, G. G., Su, X., Chen, Y., Bijan, M., Varshney, R. R., Kim, B., Dave, S. S., Rudolph, M. C. & Evens, A. M., Oct 26 2021, In: Frontiers in Oncology. 11, 725137.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

The nuclear receptor HNF4 drives a brush border gene program conserved across murine intestine, kidney, and embryonic yolk sac

Chen, L., Luo, S., Dupre, A., Vasoya, R. P., Parthasarathy, A., Aita, R., Malhotra, R., Hur, J., Toke, N. H., Chiles, E., Yang, M., Cao, W., Flores, J., Ellison, C. E., Gao, N., Sahota, A., Su, X., Bonder, E. M. & Verzi, M. P., Dec 1 2021, In: Nature communications. 12, 1, 2886.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

Utilizing tandem mass spectrometry for metabolic flux analysis

Wang, Y., Hui, S., Wondisford, F. E. & Su, X., Apr 2021, In: Laboratory Investigation. 101, 4, p. 423-429 7 p.

Rutgers, The State University

Research output: Contribution to journal › Review article › peer-review

Open Access

1 Scopus citations

2020

Glycerol not lactate is the major net carbon source for gluconeogenesis in mice during both short and prolonged fasting

Wang, Y., Kwon, H., Su, X. & Wondisford, F. E., Jan 2020, In: Molecular Metabolism. 31, p. 36-44 9 p.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

G protein-coupled kisspeptin receptor induces metabolic reprograming and tumorigenesis in estrogen receptor-negative breast cancer

Dragan, M., Nguyen, M. U., Guzman, S., Goertzen, C., Brackstone, M., Dhillo, W. S., Bech, P. R., Clarke, S., Abbara, A., Tuck, A. B., Hess, D. A., Zong, W. X., Wondisford, F. E., Su, X., Babwah, A. V. & Bhattacharya, M., Feb 1 2020, In: Cell Death and Disease. 11, 2, 106.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

HNF4 Regulates Fatty Acid Oxidation and Is Required for Renewal of Intestinal Stem Cells in Mice

Chen, L., Vasoya, R. P., Toke, N. H., Parthasarathy, A., Luo, S., Chiles, E., Flores, J., Gao, N., Bonder, E. M., Su, X. & Verzi, M. P., Mar 2020, In: Gastroenterology. 158, 4, p. 985-999.e9

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

In-Source CID Ramping and Covariant Ion Analysis of Hydrophilic Interaction Chromatography Metabolomics

Su, X., Chiles, E., Maimouni, S., Wondisford, F. E., Zong, W. X. & Song, C., Apr 7 2020, In: Analytical Chemistry. 92, 7, p. 4829-4837 9 p.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Metabolic flux analysis—linking isotope labeling and metabolic fluxes

Wang, Y., Wondisford, F. E., Song, C., Zhang, T. & Su, X., Nov 2020, In: Metabolites. 10, 11, p. 1-21 21 p., 447.

Rutgers, The State University

Research output: Contribution to journal › Review article › peer-review

Open Access

1 Scopus citations

Metabolomic differences between invasive alien plants from native and invaded habitats

Skubel, S. A., Su, X., Poulev, A., Foxcroft, L. C., Dushenkov, V. & Raskin, I., Dec 1 2020, In: Scientific reports. 10, 1, 9749.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression

Liu, J., Zhang, C., Wu, H., Sun, X. X., Li, Y., Huang, S., Yue, X., Lu, S. E., Shen, Z., Su, X., White, E., Haffty, B. G., Hu, W. & Feng, Z., Jun 1 2020, In: Journal of Clinical Investigation. 130, 6, p. 3253-3269 17 p.

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Serine Catabolism Feeds NADH when Respiration Is Impaired

Yang, L., Garcia Canaveras, J. C., Chen, Z., Wang, L., Liang, L., Jang, C., Mayr, J. A., Zhang, Z., Ghergurovich, J. M., Zhan, L., Joshi, S., Hu, Z., McReynolds, M. R., Su, X., White, E., Morscher, R. J. & Rabinowitz, J. D., Apr 7 2020, In: Cell Metabolism. 31, 4, p. 809-821.e6

Rutgers, The State University, Princeton University

Research output: Contribution to journal › Article › peer-review

Open Access