Project Details

Description

The objective of this proposal is to provide the first characterizations of
the activity of single neurons receiving dopaminergic synaptic input
(nucleus accumbens, striatum and medial prefrontal cortex) during
intravenous self-administration of cocaine. Units will be categorized with
respect to their physiological and behavioral properties in order to
establish a background for interpreting neuronal responses to cocaine.
Substantial evidence indicates that a critical mechanism by which
psychomotor stimulants produce motor output is via facilitation of
dopaminergic transmission to accumbens and striatal neurons, and that this
effect on accumbens neurons also underlies the reinforcing properties of
activity, cocaine dose (cumulative infusions) and motor variables
influenced by the drug (e.g., locomotion, stereotypy). To evaluate whether
single cells reveal any firing patterns that might uniquely represent
responses to cocaine as a reinforcer, comparisons will be made between
animals self-administering vs yoked controls (contingent vs noncontingent
delivery). Comparisons will be made across days in all the above measures
to evaluate whether any changes occur as a function of chronic self-
administration of cocaine (2-5 weeks). Neuronal firing patterns will be
characterized during administration of other types of reinforcers, such as
self-stimulation of the medial forebrain bundle/ventral tegmental area, or
food consumption. Patterns of neuronal activity showing similarities or
differences across reinforcers or across brain structures could aid in
understanding neuronal reward mechanisms involved in drug abuse.Description
StatusFinished
Effective start/end date5/1/915/31/18

Funding

  • National Institutes of Health: $290,948.00
  • National Institutes of Health
  • National Institutes of Health: $225,422.00
  • National Institutes of Health: $298,162.00
  • National Institutes of Health: $265,637.00
  • National Institutes of Health: $298,407.00
  • National Institutes of Health: $262,997.00
  • National Institutes of Health: $255,023.00
  • National Institutes of Health: $194,722.00
  • National Institutes of Health
  • National Institutes of Health: $302,889.00
  • National Institutes of Health: $307,923.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $67,337.00
  • National Institutes of Health: $256,629.00
  • National Institutes of Health: $249,702.00
  • National Institutes of Health: $259,396.00
  • National Institutes of Health: $193,316.00
  • National Institutes of Health: $249,155.00
  • National Institutes of Health
  • National Institutes of Health: $51,626.00

ASJC

  • Medicine(all)

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