Project Details

Description

Clefting of the lip and palate (CLP) is one of the most common
craniofacial anomalies, with a rate of 1:650 in the United States
population. Over 250 genetically based syndromes exist which include
cleft lip or palate as a feature of their clinical presentation. In
FY 1994, the NIDR initiated a collaborative research study with the
Lancaster Cleft Palate Clinic in Lancaster, Pa.

The Lancaster Collaborative Study of Cleft Lip and Palate (LCS) is a
large scale epidemiologic study, involving the comprehensive mapping
of highly informative DNA markers, utilizing the clinical population
from the Lancaster Cleft Palate Clinic and affiliated clinics.
Semiautomatic gene mapping technologies developed by MEDIB in ongoing
CLP studies will be applied to map gene/genes responsible for
clefting. The study population will consist of approximately 2300
patients and controls including 225 families with more than one child
affected with CLP. DNA extracted from blood or buccal cells will be
genotyped utilizing 29 panels of 12-17 microsatellite loci and
genetic linkage and association analyses will be performed.
StatusNot started

Funding

  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research

ASJC

  • Genetics
  • Epidemiology

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