Project Details
Description
DESCRIPTION (Taken directly from the application)
The syndrome of resistance to thyroid hormone is characterized by elevated
thyroid hormone levels and inappropriate TSH secretion due in almost all cases
to point mutations in the TR-b locus. Studies of these naturally occurring TR
mutations in vitro have yielded useful insights into the syndrome of RTH. Unfortunately, the generalizability of these studies to the patient's disorder
is not always clear and because of their artificial nature may not always be
secure. Confounding these issues is the clinical heterogeneity of RTH in
families with the same mutation and the description of at least distinct
varieties of RTH in man: generalized RTH (GRTH) and central RTH (CRTH). The
goal of these studies will be to define the clinical differences between these
forms of RTH and provide a molecular explanation for these differences. This
proposal will allow the Principal Investigator to devote additional time to the
clinical study of patients with RTH and the mentoring of new investigators
entering the field of thyroid research. The candidate has recently accepted the
position of Chief of Endocrinology and Professor of Medicine at the University
of Chicago. He has independent support to study thyroid hormone action (R01
DK49126 and R01 DK53036) in animals and man and TRH signaling pathways in the
pituitary (R01 DK50564). He directs a CRC protocol to evaluate and categorize
patients with RTH. He actively mentors three BC endocrinologists in thyroid
research, each having NIH K08 support for their projects. With his previous
research and mentoring success, in an environment rich with academic
opportunities, this award will allow him to increase his mentoring activities
and to enhance his own commitment to patient-oriented research.
Status | Finished |
---|---|
Effective start/end date | 7/1/01 → 5/31/06 |
Funding
- National Institute of Diabetes and Digestive and Kidney Diseases: $116,335.00
- National Institute of Diabetes and Digestive and Kidney Diseases: $101,218.00
- National Institute of Diabetes and Digestive and Kidney Diseases: $101,218.00
- National Institute of Diabetes and Digestive and Kidney Diseases: $101,218.00
- National Institute of Diabetes and Digestive and Kidney Diseases: $101,218.00
ASJC
- Endocrinology
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