Keyphrases
Endonuclease
100%
Influenza A
100%
Cap-snatching Endonuclease
100%
Drug Development
100%
Anti-influenza
66%
Structure Optimization
66%
High-throughput
66%
Viral Inhibition
66%
Optimization Path
33%
Mutant Variants
33%
Small Molecules
33%
X-ray Crystallographic Analysis
33%
Anti-influenza Drug
33%
Continuous Evolution
33%
Absorption Distribution Metabolism Excretion
33%
3-Hydroxy-4-pyridinones
33%
Molecular Targets
33%
Bromo
33%
X-ray Crystallography
33%
Micromolar Concentration
33%
Endonuclease Assays
33%
Screening Campaign
33%
Viral Endoribonuclease
33%
CC50
33%
Rapid Evaluation
33%
Resistant mutants
33%
Mouse Model System
33%
Antiviral Assay
33%
Animal Model Study
33%
Binding Pocket
33%
Cytotoxicity
33%
Fluorescence Assay
33%
Drug-like
33%
Lead Molecules
33%
Pre-mRNA
33%
Viral Polymerase
33%
In Vivo Efficacy
33%
Current Lead
33%
Medicinal Chemistry
33%
Minimal Cytotoxicity
33%
Integrated Platform
33%
In Silico Modeling
33%
MDCK Cells
33%
Distribution Evaluation
33%
Influenza
33%
Pharmacokinetic Evaluation
33%
Cap-snatching
33%
Viral Replication
33%
IC50 Value
33%
Pharmacology, Toxicology and Pharmaceutical Science
Influenza A
100%
Drug Development
100%
Endonuclease
100%
Cytotoxicity
33%
Antivirus Agent
33%
Mouse Model
16%
Molecular Target
16%
Absorption Distribution Metabolism Excretion
16%
EC50
16%
Lead Compound
16%
Messenger RNA Precursor
16%
Pharmaceutical Chemistry
16%
Pharmacokinetics
16%
Messenger RNA
16%
Biochemistry, Genetics and Molecular Biology
Endonuclease
100%
Virus Inhibition
33%
Cytotoxicity
33%
X Ray
33%
Absorption
16%
Mouse Model
16%
Metabolic Pathway
16%
Animal Model
16%
Pharmacokinetics
16%
EC50
16%
CC50
16%
Small Molecule
16%
Precursor mRNA
16%
Virus Replication
16%
Polymerase
16%
Messenger RNA
16%