The increasing prevalence of obesity is happening not only in the United States but also worldwide. According to WHO data, the prevalence of obesity has doubled since 1980. Almost 65% of the world's population lives in countries where overweight and obesity kills more people than underweight. Today, obesity affects not only adults but also children; 15-20% of children and adolescents are obese in the United States. Obesity is a serious h ealth problem worldwide. The primary cause of obesity is an energy imbalance. When energy intake is more than energy expenditure, the excess energy could be stored as triacylglycerol in the adipocytes. This excess energy can increase the number and size of adipocytes, eventually expanding the adipose tissue. Adipose tissue can be deposited under the skin and in the intra-abdominal area. More and more research has shown that adipose tissue is an endocrine organ that can regulate the whole-body energy homeostasis through the secretion of various adipose-derived hormones or adipokines and affects the function of other organs, such as the brain, liver, pancreas, and skeletal muscle. Therefore, obesity plays a key role in metabolic syndromes and is highly related to diabetes, cardiovascular disease, and cancer. The National Institutes of Health has developed some strategic plans for obesity research, including the discovery of biological mechanisms regulated to energy balance; understanding of the correlates, determinants, and consequences of obesity; the design and testing of interventions to promote healthy weight; the dissemination and implementation of research; and improvements in measurement tools, technology, and methods. Their ultimate goal is to prevent and treat obesity efficiently. Recently, researchers have been more interested in the role of natural compounds such as epigallocatechin-3-gallate from green tea, raspberry ketones from raspberries, and synephrine from orange in regulating lipid metabolism to decrease adipogenesis in vivo or in vitro.Our proposed research is seeking novel compounds from fruits and vegetables which have anti-adipogenic and anti-obesity activity and study their mode of actions.
|Effective start/end date||10/20/15 → 9/30/20|
National Institutes of Health (U.S.)