Project Details

Description

DESCRIPTION (provided by applicant)
The inhibitory action of tea (Camellia sinenis) and tea components against
carcinogenesis has been demonstrated in animal models. The overall goal of
this program project is to elucidate the mechanisms of inhibition of
carcinogenesis by tea and the active components involved. The common
hypothesis is that tea polyphenols and caffeine, and their metabolites,
inhibit carcinogenesis by suppressing cell proliferation and enhance apoptosis
via modulating key signal transduction and metabolic pathways. The inhibition
of AP-l related signaling pathways and arachidonic acid metabolism will
receive major attention. A novel hypothesis to be tested is that tea
consumption lowers body fat levels and this effect contributes to the
inhibition of carcinogenesis. The themes of the three Projects are as
follows:
Project 1, "Effects of Tea on the Formation and Growth of Skin Tumors," will
investigate the inhibition of skin carcinogenesis in UVB-induced high-risk
mice by orally and topically applied tea, caffeine, and EGCG; the mechanisms
of growth inhibition and apoptosis induction; and the role of "lowering body
fat levels" in anticarcinogenesis.
Project 2, "Inhibition of Lung Carcinogenesis and General Mechanistic
Studies," will study the entailed mechanisms in vivo and in vitro (especially
on the inhibition of signal transduction kinases), the biotransformation and
tissue levels of tea constituents, and the biological activities of key
constituents and metabolites.
Project 3, "Modulation of Signal Transduction Pathways by Tea Components" will
focus on mechanisms key? to the inhibition of cell transformation and
apoptosis in cell lines by caffeine and polyphenols as well as their
derivatives, using cell and molecular biology approaches.
Facilitated by the "Tea Chemistry and Analysis Core" and "Administrative Core,
"the three Projects are highly interactive and integrated. Jointly, we intend
to make major contributions to the use of tea for the I chemoprevention of
cancer.
StatusFinished
Effective start/end date9/17/018/31/07

Funding

  • National Institutes of Health: $1,168,439.00
  • National Institutes of Health: $1,459,410.00
  • National Institutes of Health: $1,101,370.00
  • National Institutes of Health: $1,097,872.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $1,203,499.00

ASJC

  • Medicine(all)

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