PFI-AIR:INDUSTRY-ACADEMIA RESEARCH PARTNERSHIP FOR DEVELOPING & IMPLEMENTING NON-DESTRUCTIVE CHARACTERIZATION AND ASSESSMENT OF PHARMACEUTICAL ORAL DOSAGES IN CONTINUOUS MANUFAC

Project Details

Description

This NSF Accelerating Innovation Research (AIR) project will establish a public-private ecosystem for the development and implementation of innovative strategies for non-destructive characterization and assessment of pharmaceutical oral dosage forms targeted to continuous manufacturing processes. Non-destructive testing also impacts the quality of health-care treatment, circumventing the issues posed by destructive testing, in which dosages given to patients can never be tested. Non-destructive testing additionally can provide a foundation to better understand critical scientific issues such as within-patient and patient-to-patient response variability since the variability associated with the manufacturing process can be de-convoluted by this approach. Enabling non-destructive testing has significant economic impact on the quality and control of therapeutics. From an economic perspective, non-destructive testing can provide a pathway for advancing Real-Time Release Testing (RTRT), which has the potential to reduce manufacturing costs associated with large captive waiting-for-release inventories and failed batches. Moreover, non-destructive testing can provide a competitive edge for high-quality U.S.-based manufacturing by retaining and expanding U.S. manufacturing jobs in the pharmaceutical sector.Description
StatusFinished
Effective start/end date7/1/126/30/14

Funding

  • National Science Foundation (National Science Foundation (NSF))

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