Project Details
Description
DESCRIPTION (Adapted from applicant's abstract): This is a revised
application for a Mentored Clinical Scientist Development Award. The
purpose of this application is to acquire a theoretical statistical
background and training in particular multivariate techniques, to be used to
examine psychiatric symptom data in the members of families with a high rate
of schizophrenia, to develop alternative classifications of affection status
for use in genetic linkage studies. Support through this award would enable
the applicant to develop a unique area of expertise within the field of
psychiatric genetics, contributing to the long-term career goal of research
independence.
The contribution of genetic factors to the etiology of schizophrenia is well
accepted. Multiple family studies have demonstrated elevated rates of
schizophrenia and other psychiatric disorders within the families of
schizophrenic probands. Numerous unsuccessful gene linkage studies of
schizophrenia have been conducted, using traditional clinical diagnoses to
define affection status. One possible factor contributing to these
difficulties is that current clinical diagnoses do not accurately correspond
to the patterns of symptoms seen in individuals from families with a high
rate of schizophrenia. Analysis of the transmission patterns of individual
symptom data, not only the overall diagnosis, may lead to a more useful
definition of affection status for linkage studies.
Status | Finished |
---|---|
Effective start/end date | 2/1/97 → 1/31/02 |
Funding
- National Institute of Mental Health: $145,405.00
- National Institute of Mental Health: $146,923.00
ASJC
- Psychiatry and Mental health
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