More than 20% of the American population harbor the risk factors defined for metabolic syndrome, a condition that is highly correlated with the development of type 2 diabetes and coronary heart disease. Various botanical extracts have been used in traditional medicines to treat the symptoms of diabetes, and many of these preparations contain steroidal or triterpenoid glycosides, commonly known as saponins. We have isolated an extract from the bulbs of Lilium longiflorum containing steroidal glycosides that reduced blood glucose and body weight in laboratory mice on a high fat diet. The purpose of this research is to identify and purify the steroidal glycosides from lily bulbs and determine if they are the active ingredients in the extract that had hypoglycemic and hypolipidemic effects in a mouse model. The results of this research could lead to the development of L. longiflorum bulbs, or other plant parts, as a functional food or nutritional supplement that may be consumed regularly to prevent the development of metabolic syndrome and the onset of diabetes.
|Effective start/end date||9/1/09 → 8/31/12|