β-endorphin modulation of interferon-γ, perforin and granzyme B levels in splenic NK cells: Effects of ethanol

Madhavi Dokur, Ping Chen Cui, Juan P. Advis, Dipak K. Sarkar

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The effects of ethanol and beta-endorphin (β-EP) on productions of cytolytic factors granzyme B, perforin and IFN-γ in splenic rat NK cells were determined. Intracranial administration of β-EP increased protein and mRNA levels of cytolytic factors in NK cells. Chronic ethanol feeding reduced the basal and β-EP-induced levels of cytolytic factors in NK cells. In vitro treatment of β-EP on NK cells increased the levels of perforin, granzyme B and IFN-γ and their mRNA transcripts, whereas ethanol pre-treatment prevented β-EP effects on cytolytic factors in these cells. These results suggest that β-EP and ethanol interact to regulate NK cell functions.

Original languageEnglish (US)
Pages (from-to)29-38
Number of pages10
JournalJournal of Neuroimmunology
Volume166
Issue number1-2
DOIs
StatePublished - Sep 2005

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Keywords

  • Cytotoxic factors
  • Enriched natural killer cells
  • Hypothalamus
  • Splenocytes
  • β-endorphin

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