Abstract
An emerging neuromodulation approach to treat disorders such as intractable epilepsy and Alzheimer's disease is to use electrical stimulation triggered by pathological brain states, conventionally delivered via intracranially implanted electrodes as shown in Fig. 22.8.1 (top, left). A safer, non-invasive technology for closed-loop deep-brain neuromodulation (DBN) to treat neural disorders has been a holy grail of neuroscience for decades. Recent clinical studies of non-invasive transcranial stimulation are showing increasing promise. For instance, there is evidence that stimulation in certain stages of sleep can improve memory. This work demonstrates a platform technology for enabling such studies and protocols, where brain-state-dependent stimulation enables therapy in either conventional invasive or emerging non-invasive neuromodulation modalities.
| Original language | English (US) |
|---|---|
| Title of host publication | 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019 |
| Publisher | Institute of Electrical and Electronics Engineers Inc. |
| Pages | 374-376 |
| Number of pages | 3 |
| ISBN (Electronic) | 9781538685310 |
| DOIs | |
| State | Published - Mar 6 2019 |
| Event | 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019 - San Francisco, United States Duration: Feb 17 2019 → Feb 21 2019 |
Publication series
| Name | Digest of Technical Papers - IEEE International Solid-State Circuits Conference |
|---|---|
| Volume | 2019-February |
Conference
| Conference | 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019 |
|---|---|
| Country | United States |
| City | San Francisco |
| Period | 2/17/19 → 2/21/19 |
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22.8 Adaptively Clock-Boosted Auto-Ranging Responsive Neurostimulator for Emerging Neuromodulation Applications. / Pazhouhandeh, M. Reza; Orleary, Gerard; Weisspapir, Iliya; Groppe, David; Nguyen, Xuan Thuan; Abdelhalim, Karim; Jafari, Hamed Mazhab; Valiante, Taufik A.; Carlen, Peter; Verma, Naveen; Genov, Roman.
2019 IEEE International Solid-State Circuits Conference, ISSCC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. p. 374-376 8662458 (Digest of Technical Papers - IEEE International Solid-State Circuits Conference; Vol. 2019-February).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
TY - GEN
T1 - 22.8 Adaptively Clock-Boosted Auto-Ranging Responsive Neurostimulator for Emerging Neuromodulation Applications
AU - Pazhouhandeh, M. Reza
AU - Orleary, Gerard
AU - Weisspapir, Iliya
AU - Groppe, David
AU - Nguyen, Xuan Thuan
AU - Abdelhalim, Karim
AU - Jafari, Hamed Mazhab
AU - Valiante, Taufik A.
AU - Carlen, Peter
AU - Verma, Naveen
AU - Genov, Roman
PY - 2019/3/6
Y1 - 2019/3/6
N2 - An emerging neuromodulation approach to treat disorders such as intractable epilepsy and Alzheimer's disease is to use electrical stimulation triggered by pathological brain states, conventionally delivered via intracranially implanted electrodes as shown in Fig. 22.8.1 (top, left). A safer, non-invasive technology for closed-loop deep-brain neuromodulation (DBN) to treat neural disorders has been a holy grail of neuroscience for decades. Recent clinical studies of non-invasive transcranial stimulation are showing increasing promise. For instance, there is evidence that stimulation in certain stages of sleep can improve memory. This work demonstrates a platform technology for enabling such studies and protocols, where brain-state-dependent stimulation enables therapy in either conventional invasive or emerging non-invasive neuromodulation modalities.
AB - An emerging neuromodulation approach to treat disorders such as intractable epilepsy and Alzheimer's disease is to use electrical stimulation triggered by pathological brain states, conventionally delivered via intracranially implanted electrodes as shown in Fig. 22.8.1 (top, left). A safer, non-invasive technology for closed-loop deep-brain neuromodulation (DBN) to treat neural disorders has been a holy grail of neuroscience for decades. Recent clinical studies of non-invasive transcranial stimulation are showing increasing promise. For instance, there is evidence that stimulation in certain stages of sleep can improve memory. This work demonstrates a platform technology for enabling such studies and protocols, where brain-state-dependent stimulation enables therapy in either conventional invasive or emerging non-invasive neuromodulation modalities.
UR - http://www.scopus.com/inward/record.url?scp=85063438695&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063438695&partnerID=8YFLogxK
U2 - https://doi.org/10.1109/ISSCC.2019.8662458
DO - https://doi.org/10.1109/ISSCC.2019.8662458
M3 - Conference contribution
T3 - Digest of Technical Papers - IEEE International Solid-State Circuits Conference
SP - 374
EP - 376
BT - 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019
PB - Institute of Electrical and Electronics Engineers Inc.
ER -