22.8 Adaptively Clock-Boosted Auto-Ranging Responsive Neurostimulator for Emerging Neuromodulation Applications

M. Reza Pazhouhandeh, Gerard Orleary, Iliya Weisspapir, David Groppe, Xuan Thuan Nguyen, Karim Abdelhalim, Hamed Mazhab Jafari, Taufik A. Valiante, Peter Carlen, Naveen Verma, Roman Genov

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An emerging neuromodulation approach to treat disorders such as intractable epilepsy and Alzheimer's disease is to use electrical stimulation triggered by pathological brain states, conventionally delivered via intracranially implanted electrodes as shown in Fig. 22.8.1 (top, left). A safer, non-invasive technology for closed-loop deep-brain neuromodulation (DBN) to treat neural disorders has been a holy grail of neuroscience for decades. Recent clinical studies of non-invasive transcranial stimulation are showing increasing promise. For instance, there is evidence that stimulation in certain stages of sleep can improve memory. This work demonstrates a platform technology for enabling such studies and protocols, where brain-state-dependent stimulation enables therapy in either conventional invasive or emerging non-invasive neuromodulation modalities.

Original languageEnglish (US)
Title of host publication2019 IEEE International Solid-State Circuits Conference, ISSCC 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages374-376
Number of pages3
ISBN (Electronic)9781538685310
DOIs
StatePublished - Mar 6 2019
Event2019 IEEE International Solid-State Circuits Conference, ISSCC 2019 - San Francisco, United States
Duration: Feb 17 2019Feb 21 2019

Publication series

NameDigest of Technical Papers - IEEE International Solid-State Circuits Conference
Volume2019-February

Conference

Conference2019 IEEE International Solid-State Circuits Conference, ISSCC 2019
CountryUnited States
CitySan Francisco
Period2/17/192/21/19

Fingerprint

Brain
Technology
Implanted Electrodes
Sleep Stages
Neurosciences
Electric Stimulation
Alzheimer Disease
Therapeutics
Drug Resistant Epilepsy
Clinical Studies

Cite this

Pazhouhandeh, M. R., Orleary, G., Weisspapir, I., Groppe, D., Nguyen, X. T., Abdelhalim, K., ... Genov, R. (2019). 22.8 Adaptively Clock-Boosted Auto-Ranging Responsive Neurostimulator for Emerging Neuromodulation Applications. In 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019 (pp. 374-376). [8662458] (Digest of Technical Papers - IEEE International Solid-State Circuits Conference; Vol. 2019-February). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ISSCC.2019.8662458
Pazhouhandeh, M. Reza ; Orleary, Gerard ; Weisspapir, Iliya ; Groppe, David ; Nguyen, Xuan Thuan ; Abdelhalim, Karim ; Jafari, Hamed Mazhab ; Valiante, Taufik A. ; Carlen, Peter ; Verma, Naveen ; Genov, Roman. / 22.8 Adaptively Clock-Boosted Auto-Ranging Responsive Neurostimulator for Emerging Neuromodulation Applications. 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 374-376 (Digest of Technical Papers - IEEE International Solid-State Circuits Conference).
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Pazhouhandeh, MR, Orleary, G, Weisspapir, I, Groppe, D, Nguyen, XT, Abdelhalim, K, Jafari, HM, Valiante, TA, Carlen, P, Verma, N & Genov, R 2019, 22.8 Adaptively Clock-Boosted Auto-Ranging Responsive Neurostimulator for Emerging Neuromodulation Applications. in 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019., 8662458, Digest of Technical Papers - IEEE International Solid-State Circuits Conference, vol. 2019-February, Institute of Electrical and Electronics Engineers Inc., pp. 374-376, 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019, San Francisco, United States, 2/17/19. https://doi.org/10.1109/ISSCC.2019.8662458

22.8 Adaptively Clock-Boosted Auto-Ranging Responsive Neurostimulator for Emerging Neuromodulation Applications. / Pazhouhandeh, M. Reza; Orleary, Gerard; Weisspapir, Iliya; Groppe, David; Nguyen, Xuan Thuan; Abdelhalim, Karim; Jafari, Hamed Mazhab; Valiante, Taufik A.; Carlen, Peter; Verma, Naveen; Genov, Roman.

2019 IEEE International Solid-State Circuits Conference, ISSCC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. p. 374-376 8662458 (Digest of Technical Papers - IEEE International Solid-State Circuits Conference; Vol. 2019-February).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Pazhouhandeh MR, Orleary G, Weisspapir I, Groppe D, Nguyen XT, Abdelhalim K et al. 22.8 Adaptively Clock-Boosted Auto-Ranging Responsive Neurostimulator for Emerging Neuromodulation Applications. In 2019 IEEE International Solid-State Circuits Conference, ISSCC 2019. Institute of Electrical and Electronics Engineers Inc. 2019. p. 374-376. 8662458. (Digest of Technical Papers - IEEE International Solid-State Circuits Conference). https://doi.org/10.1109/ISSCC.2019.8662458