25-hydroxyvitamin D and Vitamin D binding protein levels in patients with primary hyperparathyroidism before and after parathyroidectomy

Xiangbing Wang, Zhifeng Sheng, Lingqiong Meng, Chi Su, Stanley Trooskin, Sue A. Shapses

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate vitamin D binding protein and free 25-hydroxyvitamin D [25(OH)D] levels in healthy controls compared to primary hyperparathyroidism (PHPT) patients, and to examine PHPT before and after surgery. Methods: Seventy-five PHPT patients and 75 healthy age, gender, and body mass index (BMI) -matched control subjects were examined. In addition, 25 PHPT patients underwent parathyroidectomy and had a 3-month follow up visit. Levels of total and free 25(OH)D, DBP, and intact parathyroid hormone (iPTH) were determined before and 3 months after surgery. Results: There was no significant difference in age and BMI between PHPT patients and controls. Levels of 25(OH)D and DBP were lower in PHPT patients compared to controls (p < 0.01). There was no significant difference in calculated free and bioavailable 25(OH)D levels between PHPT patients and controls. Calcium and iPTH levels decreased to normal but DBP and DBP-bound-25(OH)D increased (P < 0.001) after parathyroidectomy. Levels of DBP were inversely correlated with iPTH (r = −0.406, P < 0.001) and calcium levels (r = −0.423, P < 0.001). Conclusion: Serum DBP levels were lower in patients with PHPT and parathyroidectomy restored DBP levels. We suggest that lower DBP levels is one of contributing mechanisms of low total 25(OH)D in PTHP patients and the total 25(OH)D levels might not reflect true vitamin D status in PHPT patients.

Original languageEnglish (US)
Article number171
JournalFrontiers in Endocrinology
Volume10
Issue numberMAR
DOIs
StatePublished - Jan 1 2019

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Vitamin D-Binding Protein
Parathyroidectomy
Primary Hyperparathyroidism
Parathyroid Hormone
Body Mass Index
Calcium
25-hydroxyvitamin D
Vitamin D

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

Keywords

  • Calcium metabolism
  • Hyperparathyroidism
  • Parathyroid hormone
  • Parathyroidectomy
  • Vitamin D binding protein
  • Vitamin D deficiency

Cite this

@article{77367582a2f440469c98433f7977d46b,
title = "25-hydroxyvitamin D and Vitamin D binding protein levels in patients with primary hyperparathyroidism before and after parathyroidectomy",
abstract = "Objective: To evaluate vitamin D binding protein and free 25-hydroxyvitamin D [25(OH)D] levels in healthy controls compared to primary hyperparathyroidism (PHPT) patients, and to examine PHPT before and after surgery. Methods: Seventy-five PHPT patients and 75 healthy age, gender, and body mass index (BMI) -matched control subjects were examined. In addition, 25 PHPT patients underwent parathyroidectomy and had a 3-month follow up visit. Levels of total and free 25(OH)D, DBP, and intact parathyroid hormone (iPTH) were determined before and 3 months after surgery. Results: There was no significant difference in age and BMI between PHPT patients and controls. Levels of 25(OH)D and DBP were lower in PHPT patients compared to controls (p < 0.01). There was no significant difference in calculated free and bioavailable 25(OH)D levels between PHPT patients and controls. Calcium and iPTH levels decreased to normal but DBP and DBP-bound-25(OH)D increased (P < 0.001) after parathyroidectomy. Levels of DBP were inversely correlated with iPTH (r = −0.406, P < 0.001) and calcium levels (r = −0.423, P < 0.001). Conclusion: Serum DBP levels were lower in patients with PHPT and parathyroidectomy restored DBP levels. We suggest that lower DBP levels is one of contributing mechanisms of low total 25(OH)D in PTHP patients and the total 25(OH)D levels might not reflect true vitamin D status in PHPT patients.",
keywords = "Calcium metabolism, Hyperparathyroidism, Parathyroid hormone, Parathyroidectomy, Vitamin D binding protein, Vitamin D deficiency",
author = "Xiangbing Wang and Zhifeng Sheng and Lingqiong Meng and Chi Su and Stanley Trooskin and Shapses, {Sue A.}",
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25-hydroxyvitamin D and Vitamin D binding protein levels in patients with primary hyperparathyroidism before and after parathyroidectomy. / Wang, Xiangbing; Sheng, Zhifeng; Meng, Lingqiong; Su, Chi; Trooskin, Stanley; Shapses, Sue A.

In: Frontiers in Endocrinology, Vol. 10, No. MAR, 171, 01.01.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - 25-hydroxyvitamin D and Vitamin D binding protein levels in patients with primary hyperparathyroidism before and after parathyroidectomy

AU - Wang, Xiangbing

AU - Sheng, Zhifeng

AU - Meng, Lingqiong

AU - Su, Chi

AU - Trooskin, Stanley

AU - Shapses, Sue A.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objective: To evaluate vitamin D binding protein and free 25-hydroxyvitamin D [25(OH)D] levels in healthy controls compared to primary hyperparathyroidism (PHPT) patients, and to examine PHPT before and after surgery. Methods: Seventy-five PHPT patients and 75 healthy age, gender, and body mass index (BMI) -matched control subjects were examined. In addition, 25 PHPT patients underwent parathyroidectomy and had a 3-month follow up visit. Levels of total and free 25(OH)D, DBP, and intact parathyroid hormone (iPTH) were determined before and 3 months after surgery. Results: There was no significant difference in age and BMI between PHPT patients and controls. Levels of 25(OH)D and DBP were lower in PHPT patients compared to controls (p < 0.01). There was no significant difference in calculated free and bioavailable 25(OH)D levels between PHPT patients and controls. Calcium and iPTH levels decreased to normal but DBP and DBP-bound-25(OH)D increased (P < 0.001) after parathyroidectomy. Levels of DBP were inversely correlated with iPTH (r = −0.406, P < 0.001) and calcium levels (r = −0.423, P < 0.001). Conclusion: Serum DBP levels were lower in patients with PHPT and parathyroidectomy restored DBP levels. We suggest that lower DBP levels is one of contributing mechanisms of low total 25(OH)D in PTHP patients and the total 25(OH)D levels might not reflect true vitamin D status in PHPT patients.

AB - Objective: To evaluate vitamin D binding protein and free 25-hydroxyvitamin D [25(OH)D] levels in healthy controls compared to primary hyperparathyroidism (PHPT) patients, and to examine PHPT before and after surgery. Methods: Seventy-five PHPT patients and 75 healthy age, gender, and body mass index (BMI) -matched control subjects were examined. In addition, 25 PHPT patients underwent parathyroidectomy and had a 3-month follow up visit. Levels of total and free 25(OH)D, DBP, and intact parathyroid hormone (iPTH) were determined before and 3 months after surgery. Results: There was no significant difference in age and BMI between PHPT patients and controls. Levels of 25(OH)D and DBP were lower in PHPT patients compared to controls (p < 0.01). There was no significant difference in calculated free and bioavailable 25(OH)D levels between PHPT patients and controls. Calcium and iPTH levels decreased to normal but DBP and DBP-bound-25(OH)D increased (P < 0.001) after parathyroidectomy. Levels of DBP were inversely correlated with iPTH (r = −0.406, P < 0.001) and calcium levels (r = −0.423, P < 0.001). Conclusion: Serum DBP levels were lower in patients with PHPT and parathyroidectomy restored DBP levels. We suggest that lower DBP levels is one of contributing mechanisms of low total 25(OH)D in PTHP patients and the total 25(OH)D levels might not reflect true vitamin D status in PHPT patients.

KW - Calcium metabolism

KW - Hyperparathyroidism

KW - Parathyroid hormone

KW - Parathyroidectomy

KW - Vitamin D binding protein

KW - Vitamin D deficiency

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U2 - https://doi.org/10.3389/fendo.2019.00171

DO - https://doi.org/10.3389/fendo.2019.00171

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