2D Magnetic Sensor Array for Real-time Cell Tracking and Multi-site Detection with Increased Robustness and Flow-rate

Hao Tang, Suresh Venkatesh, Zhongtian Lin, Xuyang Lu, Hooman Saeidi, Gulam M. Rather, Joseph R. Bertino, Chen Yong Lin, Mehdi Javanmard, Kaushik Sengupta

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this article, we present a 2D oscillator array-based magnetic sensor CMOS IC for flow cytometry. The CMOS IC packaged with a microfluidic channel eliminates the need for hydro-focusing by allowing uninhibited flow over the 2D chip surface. The chip exploits multi-site detection capability allowing simultaneously high flow rate for trace cell detection, reduced false positives, and real-time cell tracking. We demonstrate these functionalities with a 7 × 7 array in 65-nm CMOS with lymphoma cancer cells.

Original languageEnglish (US)
Title of host publication2019 IEEE Custom Integrated Circuits Conference, CICC 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781538693957
DOIs
StatePublished - Apr 1 2019
Event40th Annual IEEE Custom Integrated Circuits Conference, CICC 2019 - Austin, United States
Duration: Apr 14 2019Apr 17 2019

Publication series

NameProceedings of the Custom Integrated Circuits Conference
Volume2019-April

Conference

Conference40th Annual IEEE Custom Integrated Circuits Conference, CICC 2019
CountryUnited States
CityAustin
Period4/14/194/17/19

Fingerprint

Magnetic sensors
Flow cytometry
Sensor arrays
Microfluidics
Cells
Flow rate

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering

Cite this

Tang, H., Venkatesh, S., Lin, Z., Lu, X., Saeidi, H., Rather, G. M., ... Sengupta, K. (2019). 2D Magnetic Sensor Array for Real-time Cell Tracking and Multi-site Detection with Increased Robustness and Flow-rate. In 2019 IEEE Custom Integrated Circuits Conference, CICC 2019 [8780363] (Proceedings of the Custom Integrated Circuits Conference; Vol. 2019-April). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/CICC.2019.8780363
Tang, Hao ; Venkatesh, Suresh ; Lin, Zhongtian ; Lu, Xuyang ; Saeidi, Hooman ; Rather, Gulam M. ; Bertino, Joseph R. ; Lin, Chen Yong ; Javanmard, Mehdi ; Sengupta, Kaushik. / 2D Magnetic Sensor Array for Real-time Cell Tracking and Multi-site Detection with Increased Robustness and Flow-rate. 2019 IEEE Custom Integrated Circuits Conference, CICC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. (Proceedings of the Custom Integrated Circuits Conference).
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abstract = "In this article, we present a 2D oscillator array-based magnetic sensor CMOS IC for flow cytometry. The CMOS IC packaged with a microfluidic channel eliminates the need for hydro-focusing by allowing uninhibited flow over the 2D chip surface. The chip exploits multi-site detection capability allowing simultaneously high flow rate for trace cell detection, reduced false positives, and real-time cell tracking. We demonstrate these functionalities with a 7 × 7 array in 65-nm CMOS with lymphoma cancer cells.",
author = "Hao Tang and Suresh Venkatesh and Zhongtian Lin and Xuyang Lu and Hooman Saeidi and Rather, {Gulam M.} and Bertino, {Joseph R.} and Lin, {Chen Yong} and Mehdi Javanmard and Kaushik Sengupta",
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Tang, H, Venkatesh, S, Lin, Z, Lu, X, Saeidi, H, Rather, GM, Bertino, JR, Lin, CY, Javanmard, M & Sengupta, K 2019, 2D Magnetic Sensor Array for Real-time Cell Tracking and Multi-site Detection with Increased Robustness and Flow-rate. in 2019 IEEE Custom Integrated Circuits Conference, CICC 2019., 8780363, Proceedings of the Custom Integrated Circuits Conference, vol. 2019-April, Institute of Electrical and Electronics Engineers Inc., 40th Annual IEEE Custom Integrated Circuits Conference, CICC 2019, Austin, United States, 4/14/19. https://doi.org/10.1109/CICC.2019.8780363

2D Magnetic Sensor Array for Real-time Cell Tracking and Multi-site Detection with Increased Robustness and Flow-rate. / Tang, Hao; Venkatesh, Suresh; Lin, Zhongtian; Lu, Xuyang; Saeidi, Hooman; Rather, Gulam M.; Bertino, Joseph R.; Lin, Chen Yong; Javanmard, Mehdi; Sengupta, Kaushik.

2019 IEEE Custom Integrated Circuits Conference, CICC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. 8780363 (Proceedings of the Custom Integrated Circuits Conference; Vol. 2019-April).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Tang H, Venkatesh S, Lin Z, Lu X, Saeidi H, Rather GM et al. 2D Magnetic Sensor Array for Real-time Cell Tracking and Multi-site Detection with Increased Robustness and Flow-rate. In 2019 IEEE Custom Integrated Circuits Conference, CICC 2019. Institute of Electrical and Electronics Engineers Inc. 2019. 8780363. (Proceedings of the Custom Integrated Circuits Conference). https://doi.org/10.1109/CICC.2019.8780363