5HT3 receptor antagonists block morphine- and nicotine-but not amphetamine-induced reward

E. Carboni, E. Acquas, P. Leone, G. Di Chiara

Research output: Contribution to journalArticlepeer-review

170 Scopus citations

Abstract

The effect of two potent and specific antagonists of 5HT3 receptors, ICS 205-930 and MDL 72222, on the reinforcing properties of amphetamine, morphine and nicotine was studied in rats. Durg-induced reinforcement was assessed by measuring drug-conditioned place preference. ICS 205-930 and MDL 72222 dose-dependently reduced the place preference induced by morphine (1.0 mg/kg SC). At doses of 0.030 mg/kg SC the two antagonists completely blocked morphine-induced place preference while doses of 0.015 mg/kg SC significantly reduced it. ICS 205-930 and MDL 72222 at doses of 0.030 mg/kg SC also prevented the place preference induced by nicotine (0.6 mg/kg SC). In contrast, ICS 205-930 and MDL 72222 up to doses of 0.030 mg/kg SC failed to modify the place preference elicited by amphetamine (1.0 mg/kg SC). The results indicate that 5HT3 receptors are specifically involved in the reinforcing properties of morphine and nicotine.

Original languageEnglish (US)
Pages (from-to)175-178
Number of pages4
JournalPsychopharmacology
Volume97
Issue number2
DOIs
StatePublished - Feb 1 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology

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