5HT3 receptor antagonists block morphine- and nicotine-but not amphetamine-induced reward

E. Carboni; E. Acquas; P. Leone; G. Di Chiara

doi:10.1007/BF00442245

5HT₃ receptor antagonists block morphine- and nicotine-but not amphetamine-induced reward

E. Carboni
, E. Acquas
, P. Leone
, G. Di Chiara

Research output: Contribution to journal › Article › peer-review

170 Scopus citations

Abstract

The effect of two potent and specific antagonists of 5HT₃ receptors, ICS 205-930 and MDL 72222, on the reinforcing properties of amphetamine, morphine and nicotine was studied in rats. Durg-induced reinforcement was assessed by measuring drug-conditioned place preference. ICS 205-930 and MDL 72222 dose-dependently reduced the place preference induced by morphine (1.0 mg/kg SC). At doses of 0.030 mg/kg SC the two antagonists completely blocked morphine-induced place preference while doses of 0.015 mg/kg SC significantly reduced it. ICS 205-930 and MDL 72222 at doses of 0.030 mg/kg SC also prevented the place preference induced by nicotine (0.6 mg/kg SC). In contrast, ICS 205-930 and MDL 72222 up to doses of 0.030 mg/kg SC failed to modify the place preference elicited by amphetamine (1.0 mg/kg SC). The results indicate that 5HT₃ receptors are specifically involved in the reinforcing properties of morphine and nicotine.

Original language	English (US)
Pages (from-to)	175-178
Number of pages	4
Journal	Psychopharmacology
Volume	97
Issue number	2
DOIs	https://doi.org/10.1007/BF00442245
State	Published - Feb 1989
Externally published	Yes

ASJC Scopus subject areas

Pharmacology

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10.1007/BF00442245

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@article{ef5560fc4f03432bb82a61b148d8ac35,

title = "5HT3 receptor antagonists block morphine- and nicotine-but not amphetamine-induced reward",

abstract = "The effect of two potent and specific antagonists of 5HT3 receptors, ICS 205-930 and MDL 72222, on the reinforcing properties of amphetamine, morphine and nicotine was studied in rats. Durg-induced reinforcement was assessed by measuring drug-conditioned place preference. ICS 205-930 and MDL 72222 dose-dependently reduced the place preference induced by morphine (1.0 mg/kg SC). At doses of 0.030 mg/kg SC the two antagonists completely blocked morphine-induced place preference while doses of 0.015 mg/kg SC significantly reduced it. ICS 205-930 and MDL 72222 at doses of 0.030 mg/kg SC also prevented the place preference induced by nicotine (0.6 mg/kg SC). In contrast, ICS 205-930 and MDL 72222 up to doses of 0.030 mg/kg SC failed to modify the place preference elicited by amphetamine (1.0 mg/kg SC). The results indicate that 5HT3 receptors are specifically involved in the reinforcing properties of morphine and nicotine.",

author = "E. Carboni and E. Acquas and P. Leone and \{Di Chiara\}, G.",

year = "1989",

month = feb,

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T1 - 5HT3 receptor antagonists block morphine- and nicotine-but not amphetamine-induced reward

AU - Carboni, E.

AU - Acquas, E.

AU - Leone, P.

AU - Di Chiara, G.

PY - 1989/2

Y1 - 1989/2

N2 - The effect of two potent and specific antagonists of 5HT3 receptors, ICS 205-930 and MDL 72222, on the reinforcing properties of amphetamine, morphine and nicotine was studied in rats. Durg-induced reinforcement was assessed by measuring drug-conditioned place preference. ICS 205-930 and MDL 72222 dose-dependently reduced the place preference induced by morphine (1.0 mg/kg SC). At doses of 0.030 mg/kg SC the two antagonists completely blocked morphine-induced place preference while doses of 0.015 mg/kg SC significantly reduced it. ICS 205-930 and MDL 72222 at doses of 0.030 mg/kg SC also prevented the place preference induced by nicotine (0.6 mg/kg SC). In contrast, ICS 205-930 and MDL 72222 up to doses of 0.030 mg/kg SC failed to modify the place preference elicited by amphetamine (1.0 mg/kg SC). The results indicate that 5HT3 receptors are specifically involved in the reinforcing properties of morphine and nicotine.

AB - The effect of two potent and specific antagonists of 5HT3 receptors, ICS 205-930 and MDL 72222, on the reinforcing properties of amphetamine, morphine and nicotine was studied in rats. Durg-induced reinforcement was assessed by measuring drug-conditioned place preference. ICS 205-930 and MDL 72222 dose-dependently reduced the place preference induced by morphine (1.0 mg/kg SC). At doses of 0.030 mg/kg SC the two antagonists completely blocked morphine-induced place preference while doses of 0.015 mg/kg SC significantly reduced it. ICS 205-930 and MDL 72222 at doses of 0.030 mg/kg SC also prevented the place preference induced by nicotine (0.6 mg/kg SC). In contrast, ICS 205-930 and MDL 72222 up to doses of 0.030 mg/kg SC failed to modify the place preference elicited by amphetamine (1.0 mg/kg SC). The results indicate that 5HT3 receptors are specifically involved in the reinforcing properties of morphine and nicotine.

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U2 - 10.1007/BF00442245

DO - 10.1007/BF00442245

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JO - Psychopharmacology

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ER -

5HT₃ receptor antagonists block morphine- and nicotine-but not amphetamine-induced reward

Abstract

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