A case-control study of reproductive factors, female hormone use, and risk of pancreatic cancer

Yuqing Zhang, Patricia F. Coogan, Julie R. Palmer, Brian Strom, Lynn Rosenberg

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Findings from several previous studies that have assessed the relation of reproductive factors and female hormone use to the risk of pancreatic cancer are inconclusive. The authors examined the association between reproductive factors and the use of oral contraceptives and postmenopausal hormone therapy to the risk of pancreatic cancer among 284 patients with pancreatic cancer and 1,096 controls using data from the hospital-based Case-Control Surveillance Study. Older age at first pregnancy and longduration oral contraceptive use were associated with an increased risk of pancreatic cancer: the odds ratio was 2.0 (95% CI: 1.1-3.3) for first birth at age 30 or older compared with before age 20 (p for trend = 0.042) and 2.0 (95% CI: 1.0-4.0) for ten or more years of use of oral contraceptive use relative to no-use (p for trend < 0.01). Risk of pancreatic cancer risk was not associated with postmenopausal female hormone use. The findings suggest that increased exposure to estrogen during the reproductive years may play a role in the development of pancreatic cancer in women. Further studies are needed to confirm the findings.

Original languageEnglish (US)
Pages (from-to)473-478
Number of pages6
JournalCancer Causes and Control
Volume21
Issue number3
DOIs
StatePublished - Mar 1 2010

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Pancreatic Neoplasms
Case-Control Studies
Hormones
Oral Contraceptives
Birth Order
Estrogens
Odds Ratio
Pregnancy

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Zhang, Yuqing ; Coogan, Patricia F. ; Palmer, Julie R. ; Strom, Brian ; Rosenberg, Lynn. / A case-control study of reproductive factors, female hormone use, and risk of pancreatic cancer. In: Cancer Causes and Control. 2010 ; Vol. 21, No. 3. pp. 473-478.
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A case-control study of reproductive factors, female hormone use, and risk of pancreatic cancer. / Zhang, Yuqing; Coogan, Patricia F.; Palmer, Julie R.; Strom, Brian; Rosenberg, Lynn.

In: Cancer Causes and Control, Vol. 21, No. 3, 01.03.2010, p. 473-478.

Research output: Contribution to journalArticle

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