A cytogenetic study of children with psychiatric disorders

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4 Scopus citations

Abstract

The development of techniques permitting the visualization of chromosomal cross-bands has greatly enhanced the field of human cytogenetics. It has led to the exact identification of chromosomes and the detection of subtle chromosomal changes characterizing new clinical syndromes.1-4. The G (Giemsa) and Q (Quinacrine mustard) banding techniques are the most widely used. As a relatively simple and replicable procedure, G banding is the method of choice for clinical application. It is attained by staining the chromosome preparation with Giemsa-like stains. The resulting thick dark staining cross-bands that alternate with lighter ones confer distinctive features to each chromosomal pair. By using elongated chromosomes from late prophase or early metaphase instead of the customary late metaphases, the visual resolution is greatly increased, making it feasible to detect chromosomal changes on different groups of patients. The major psychiatric illnesses are important to study with the new techniques because (1) they have a strong genetic component and (2) an association between chromosomal changes and psychiatric disorders has been proposed. A population of children affected with psychiatric disorders was chosen for the present study since extraneous factors such as drugs, chronic physical illness, and institutionalization are less likely to play a role in the nature-nurture interaction.

Original languageEnglish (US)
Pages (from-to)309-313
Number of pages5
JournalComprehensive Psychiatry
Volume17
Issue number2
DOIs
StatePublished - 1976
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

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