A DEM model-based study to quantitatively compare the effect of wet and dry binder addition in high-shear wet granulation processes

Ashutosh Tamrakar, Sheng Wen Chen, Rohit Ramachandran

Research output: Contribution to journalArticle

Abstract

Wet granulation is widely used in many particulate industries for its capability to improve flowability and handling of powder substances. A mathematical model using discrete element methodology (DEM) was developed to study two kinds of binder addition approaches commonly used during wet granulation in a batch high-shear granulator: wet binder addition (WBA) and dry binder addition (DBA). To define the complex interactions in the systems, a novel integrated DEM algorithm that incorporates powder wetting behavior, capillary and viscous liquid bridge formation as well as binder dissolution was developed. DEM simulation results show a significant difference between the viscous regions in the particle bed for the two systems: the WBA approach quickly wets the majority of the particle bed with a low viscosity fluid, while in the DBA approach fewer particles with higher viscous surface liquid are generated that are responsible for a delayed but faster granule growth rate. The difference in the viscosity of the surface liquid in the two systems lead to varying strengths and numbers of the liquid bridge formed between particles as well as particle velocities. In general, the high viscous areas are dependent on the binder and liquid dispersion which are affected by the mechanical agitation.

Original languageEnglish (US)
Pages (from-to)307-326
Number of pages20
JournalChemical Engineering Research and Design
DOIs
StatePublished - Feb 1 2019

Fingerprint

Granulation
Binders
Liquids
Powders
Granulators
Viscosity
Wetting
Dissolution
Mathematical models
Fluids
Industry

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Chemistry(all)

Keywords

  • Binder dissolution
  • Discrete element model
  • Dry binder addition
  • Wet binder addition
  • Wet granulation

Cite this

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title = "A DEM model-based study to quantitatively compare the effect of wet and dry binder addition in high-shear wet granulation processes",
abstract = "Wet granulation is widely used in many particulate industries for its capability to improve flowability and handling of powder substances. A mathematical model using discrete element methodology (DEM) was developed to study two kinds of binder addition approaches commonly used during wet granulation in a batch high-shear granulator: wet binder addition (WBA) and dry binder addition (DBA). To define the complex interactions in the systems, a novel integrated DEM algorithm that incorporates powder wetting behavior, capillary and viscous liquid bridge formation as well as binder dissolution was developed. DEM simulation results show a significant difference between the viscous regions in the particle bed for the two systems: the WBA approach quickly wets the majority of the particle bed with a low viscosity fluid, while in the DBA approach fewer particles with higher viscous surface liquid are generated that are responsible for a delayed but faster granule growth rate. The difference in the viscosity of the surface liquid in the two systems lead to varying strengths and numbers of the liquid bridge formed between particles as well as particle velocities. In general, the high viscous areas are dependent on the binder and liquid dispersion which are affected by the mechanical agitation.",
keywords = "Binder dissolution, Discrete element model, Dry binder addition, Wet binder addition, Wet granulation",
author = "Ashutosh Tamrakar and Chen, {Sheng Wen} and Rohit Ramachandran",
year = "2019",
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doi = "https://doi.org/10.1016/j.cherd.2018.12.016",
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journal = "Chemical Engineering Research and Design",
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AU - Tamrakar, Ashutosh

AU - Chen, Sheng Wen

AU - Ramachandran, Rohit

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Wet granulation is widely used in many particulate industries for its capability to improve flowability and handling of powder substances. A mathematical model using discrete element methodology (DEM) was developed to study two kinds of binder addition approaches commonly used during wet granulation in a batch high-shear granulator: wet binder addition (WBA) and dry binder addition (DBA). To define the complex interactions in the systems, a novel integrated DEM algorithm that incorporates powder wetting behavior, capillary and viscous liquid bridge formation as well as binder dissolution was developed. DEM simulation results show a significant difference between the viscous regions in the particle bed for the two systems: the WBA approach quickly wets the majority of the particle bed with a low viscosity fluid, while in the DBA approach fewer particles with higher viscous surface liquid are generated that are responsible for a delayed but faster granule growth rate. The difference in the viscosity of the surface liquid in the two systems lead to varying strengths and numbers of the liquid bridge formed between particles as well as particle velocities. In general, the high viscous areas are dependent on the binder and liquid dispersion which are affected by the mechanical agitation.

AB - Wet granulation is widely used in many particulate industries for its capability to improve flowability and handling of powder substances. A mathematical model using discrete element methodology (DEM) was developed to study two kinds of binder addition approaches commonly used during wet granulation in a batch high-shear granulator: wet binder addition (WBA) and dry binder addition (DBA). To define the complex interactions in the systems, a novel integrated DEM algorithm that incorporates powder wetting behavior, capillary and viscous liquid bridge formation as well as binder dissolution was developed. DEM simulation results show a significant difference between the viscous regions in the particle bed for the two systems: the WBA approach quickly wets the majority of the particle bed with a low viscosity fluid, while in the DBA approach fewer particles with higher viscous surface liquid are generated that are responsible for a delayed but faster granule growth rate. The difference in the viscosity of the surface liquid in the two systems lead to varying strengths and numbers of the liquid bridge formed between particles as well as particle velocities. In general, the high viscous areas are dependent on the binder and liquid dispersion which are affected by the mechanical agitation.

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