A dose‐intensive regimen of 5‐fluorouracil for the treatment of metastatic colorectal carcinoma

Elizabeth A. Poplin, Michael Kraut, Laurence Baker, Joanne Brodfuehrer, Vainutis Vaitkevicius

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10 Scopus citations

Abstract

5‐Fluorouracil (5‐FU) was delivered in a dose‐intensive schedule to 23 patients with metastatic or unresectable colorectal carcinoma. The schedule consisted of bolus single‐dose 5‐FU therapy 400 to 500 mg followed by 4‐day infusion of 5‐FU, 600 to 800 mg/m2/day, followed by a 17‐day to 24‐day infusion of 200 to 250 mg/m2/day. Partial remissions were seen in 22% of all eligible patients. Significant toxicity, including mucositis, diarrhea, and hand–foot syndrome, necessitated dose reductions in most patients. The authors conclude that 5‐FU given in this moderately intensive schedule is associated with a moderate level of response, as easily achieved with more conventional schedules or with 5‐FU–leucovorin combinations. Tumor responsiveness to dose intensive 5‐FU regimens may be limited.

Original languageEnglish (US)
Pages (from-to)367-371
Number of pages5
JournalCancer
Volume67
Issue number2
DOIs
StatePublished - Jan 15 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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