A genome scan in 260 inflammatory bowel disease-affected relative pairs

M. Michael Barmada, Steven R. Brant, Dan L. Nicolae, Jean Paul Achkar, Carolien I. Panhuysen, Theodore M. Bayless, Judy H. Cho, Richard H. Duerr

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

We report the results of a new genome scan in 260 IBD-affected relative pairs from 139 families that we have recruited since our previous IBD genome scans were performed. The goal of our study was to determine whether we could extend the linkage evidence in any of the more than 20 regions with nominal evidence for linkage to IBD in previous individual genome scans in order to prioritize regions for further study.

Original languageEnglish (US)
Pages (from-to)15-22
Number of pages8
JournalInflammatory bowel diseases
Volume10
Issue number1
DOIs
StatePublished - Jan 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Gastroenterology
  • Immunology and Allergy

Keywords

  • Chromosome mapping
  • Colitis, ulcerative/*genetics
  • Crohn's disease/*genetics
  • Genetic predisposition to disease
  • Genotype
  • Human
  • Inflammatory bowel diseases/*genetics
  • Linkage (genetics)
  • Major histocompatibility complex

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