A modeling, control, sensing, and experimental overview of continuous wet granulation

TY - CHAP

T1 - A modeling, control, sensing, and experimental overview of continuous wet granulation

AU - Muddu, Shashank Venkat

AU - Ramachandran, Rohit

N1 - Publisher Copyright: © 2022 Elsevier Inc. All rights reserved.

PY - 2022/1/1

Y1 - 2022/1/1

N2 - This chapter begins with a brief summary of the mechanics governing the wet granulation process. The shift toward Quality by Design methods and their application to continuous granulation, owing to industry trends and interest by regulatory agencies, has been reviewed. A literature survey has been presented on the experimental/processing work carried out in recent years, with a special emphasis on residence time distribution (RTD) experimentation techniques. The recent modeling works done at various scales, i.e., macroscale population balance modeling, mesoscale/particulate scale discrete element modeling, and overall processing line scale flowsheet modeling and simulation, have been detailed. The chapter concludes with the presentation of two case studies, each for twin-screw granulator and high shear granulator, respectively. The case studies present the authors' own work in the field of RTD experimentation, modeling, and parameter estimation.

AB - This chapter begins with a brief summary of the mechanics governing the wet granulation process. The shift toward Quality by Design methods and their application to continuous granulation, owing to industry trends and interest by regulatory agencies, has been reviewed. A literature survey has been presented on the experimental/processing work carried out in recent years, with a special emphasis on residence time distribution (RTD) experimentation techniques. The recent modeling works done at various scales, i.e., macroscale population balance modeling, mesoscale/particulate scale discrete element modeling, and overall processing line scale flowsheet modeling and simulation, have been detailed. The chapter concludes with the presentation of two case studies, each for twin-screw granulator and high shear granulator, respectively. The case studies present the authors' own work in the field of RTD experimentation, modeling, and parameter estimation.

KW - High shear granulator

KW - Population balance modeling

KW - Residence time distribution

KW - Twin-screw granulator

KW - Wet granulation

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U2 - https://doi.org/10.1016/B978-0-12-813479-5.00015-X

DO - https://doi.org/10.1016/B978-0-12-813479-5.00015-X

M3 - Chapter

SN - 9780128134801

SP - 119

EP - 139

BT - How to Design and Implement Powder-to-Tablet Continuous Manufacturing Systems

PB - Elsevier

ER -