A new flexible manufacturing process for tailoring release rates in controlled release packaging and drug delivery systems

X. Jin, D. A. Zumbrunnen, A. Balasubramanian, K. Yam

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Smart blenders controllably form multi-component polymer melts into a wide variety of fine-scale structural arrangements. The machines operate on the principal of chaotic advection, a recent subfield of fluid mechanics. Because structure of a composite material influences greatly additive diffusion and matrix dissolution, this processing method may be useful for designing medications, transdermal patches, implants, and sutures in medical applications. It may also provide desired release rates of active compounds such as antioxidants and antimicrobial from packaging films to enhance the quality and safety of food. In this paper, an ability to alter release rates of tocopherol, a natural antioxidant, is demonstrated via on-line specification of a process parameter governing blend morphology in extruded films.

Original languageAmerican English
Title of host publication67th Annual Technical Conference of the Society of Plastics Engineers 2009, ANTEC 2009
Pages2521-2525
Number of pages5
StatePublished - 2009
Event67th Annual Technical Conference of the Society of Plastics Engineers 2009, ANTEC 2009 - Chicago, IL, United States
Duration: Jun 22 2009Jun 24 2009

Publication series

NameAnnual Technical Conference - ANTEC, Conference Proceedings
Volume5

Other

Other67th Annual Technical Conference of the Society of Plastics Engineers 2009, ANTEC 2009
Country/TerritoryUnited States
CityChicago, IL
Period6/22/096/24/09

ASJC Scopus subject areas

  • General Chemical Engineering
  • Polymers and Plastics

Keywords

  • Active packaging
  • Chaotic advection
  • Chaotic mixing
  • Controlled release
  • Drug delivery
  • Smart blending

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