A Notch Sweeter

TY - JOUR

T1 - A Notch Sweeter

AU - Irvine, Kenneth D.

PY - 2008/1/25

Y1 - 2008/1/25

N2 - Notch is a key signaling protein mediating cell-fate decisions during development. In this issue, Acar et al. (2008) describe a new gene called rumi that is required for Notch signaling in Drosophila. This gene encodes an O-glucosyltransferase that attaches glucose sugars to serine residues in the multiple EGF domains of the extracellular region of Notch. This modification by Rumi likely influences Notch folding and trafficking.

AB - Notch is a key signaling protein mediating cell-fate decisions during development. In this issue, Acar et al. (2008) describe a new gene called rumi that is required for Notch signaling in Drosophila. This gene encodes an O-glucosyltransferase that attaches glucose sugars to serine residues in the multiple EGF domains of the extracellular region of Notch. This modification by Rumi likely influences Notch folding and trafficking.

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U2 - 10.1016/j.cell.2008.01.005

DO - 10.1016/j.cell.2008.01.005

M3 - Short survey

C2 - 18243091

SN - 0092-8674

VL - 132

SP - 177

EP - 179

JO - Cell

JF - Cell

IS - 2

ER -