A novel tumor suppressing gene, ARHGAP9, is an independent prognostic biomarker for bladder cancer

Xuan Mei Piao, Pildu Jeong, Chunri Yan, Ye Hwan Kim, Young Joon Byun, Yanjie Xu, Ho Won Kang, Sung Phil Seo, Won Tae Kim, Jong Young Lee, Isaac Y. Kim, Sung Kwon Moon, Yung Hyun Choi, Eun Jong Cha, Seok Joong Yun, Wun Jae Kim

Research output: Contribution to journalArticle

Abstract

Screening for genes or markers relevant to bladder cancer (BC) tumorigenesis and progression is of vital clinical significance. The present study used reverse-transcription quantitative PCR reaction assays to examine the expression of mRNA encoding Rho GTPase-activating protein 9 (ARHGAP9) in BC tissue samples and to determine whether ARHGAP9 is an independent prognostic biomarker for non-muscle invasive BC (NMIBC) and muscle invasive BC (MIBC). The results revealed that the downregulation of ARHGAP9 expression in the tissue of patients with NMIBC or MIBC was significantly associated with a poor prognosis. In patients with NMIBC, a high expression of ARHGAP9 was significantly associated with prolonged recurrence-free survival, whereas in MIBC patients, it was significantly associated with an increased progression-free and cancer-specific survival. The risk of cancer-specific death was 2.923 times higher (95% confidence interval, 1.192-7.163) when ARHGAP9 levels were decreased. In conclusion, lower expressions of ARHGAP9 correlated with BC prognosis, indicating that it may be a useful marker for guiding treatment application.

Original languageEnglish (US)
Pages (from-to)476-486
Number of pages11
JournalOncology Letters
Volume19
Issue number1
DOIs
StatePublished - Jan 1 2020

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Keywords

  • Muscle invasive bladder cancer
  • Non-muscle invasive bladder cancer
  • Progression
  • Recurrence
  • Rho GTPase-activating protein 9

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  • Cite this

    Piao, X. M., Jeong, P., Yan, C., Kim, Y. H., Byun, Y. J., Xu, Y., Kang, H. W., Seo, S. P., Kim, W. T., Lee, J. Y., Kim, I. Y., Moon, S. K., Choi, Y. H., Cha, E. J., Yun, S. J., & Kim, W. J. (2020). A novel tumor suppressing gene, ARHGAP9, is an independent prognostic biomarker for bladder cancer. Oncology Letters, 19(1), 476-486. https://doi.org/10.3892/ol.2019.11123