A percutaneous needle biopsy technique for sampling the supraclavicular brown adipose tissue depot of humans

M. Chondronikola, P. Annamalai, T. Chao, C. Porter, M. K. Saraf, F. Cesani, Labros Sidossis

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Brown adipose tissue (BAT) has been proposed as a potential target tissue against obesity and its related metabolic complications. Although the molecular and functional characteristics of BAT have been intensively studied in rodents, only a few studies have used human BAT specimens due to the difficulty of sampling human BAT deposits. We established a novel positron emission tomography and computed tomography-guided Bergström needle biopsy technique to acquire human BAT specimens from the supraclavicular area in human subjects. Forty-three biopsies were performed on 23 participants. The procedure was tolerated well by the majority of participants. No major complications were noted. Numbness (9.6%) and hematoma (2.3%) were the two minor complications noted, which fully resolved. Thus, the proposed biopsy technique can be considered safe with only minimal risk of adverse events. Adoption of the proposed method is expected to increase the sampling of the supraclavicular BAT depot for research purposes so as to augment the scientific knowledge of the biology of human BAT.

Original languageEnglish (US)
Pages (from-to)1561-1564
Number of pages4
JournalInternational Journal of Obesity
Volume39
Issue number10
DOIs
StatePublished - Oct 1 2015
Externally publishedYes

Fingerprint

Brown Adipose Tissue
Needle Biopsy
Biopsy
Hypesthesia
Hematoma
Rodentia
Obesity
Research

All Science Journal Classification (ASJC) codes

  • Nutrition and Dietetics
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism

Cite this

Chondronikola, M. ; Annamalai, P. ; Chao, T. ; Porter, C. ; Saraf, M. K. ; Cesani, F. ; Sidossis, Labros. / A percutaneous needle biopsy technique for sampling the supraclavicular brown adipose tissue depot of humans. In: International Journal of Obesity. 2015 ; Vol. 39, No. 10. pp. 1561-1564.
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A percutaneous needle biopsy technique for sampling the supraclavicular brown adipose tissue depot of humans. / Chondronikola, M.; Annamalai, P.; Chao, T.; Porter, C.; Saraf, M. K.; Cesani, F.; Sidossis, Labros.

In: International Journal of Obesity, Vol. 39, No. 10, 01.10.2015, p. 1561-1564.

Research output: Contribution to journalArticle

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