A positive-selection function for microRNA: An adaptor hypothesis revisited

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Abstract

A hypothesis for coding different combinations of mRNA segments by a novel postulated function of microRNAs (miRNA) is presented. In this hypothesis, miRNA act as both coding adaptors and ligating enzymes. This hypothesis postulates an enzyme-substrate intermediate comprising a RNA triplex structure consisting of a miRNA adaptor and two mRNA configured as two turns of an A-form RNA helix. Postulating the existence of differentially expressed sets of adaptors (codes) may explain biological functions such as imprinting, differentiation, immunological escape and immunological tolerance, inter alia.

Original languageEnglish (US)
Article number2080
Pages (from-to)292-297
Number of pages6
JournalReproductive BioMedicine Online
Volume12
Issue number3
DOIs
StatePublished - Mar 2006

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Developmental Biology

Keywords

  • Adaptor
  • Combinatorial
  • Hypothesis
  • Ligase
  • miRNA
  • tRNA

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