A Primate Model for Enteral Nutrition by Tube

Lenora R. Barot, John L. Rombeau, T. Peter Stein, Ronni Chernoff, R. G. Settle, James L. Mullen

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

To establish an animal model for the controlled study of enteral nutrition by tube, five adult chair-adapted primates (Macaca fasicularis) had gastrostomy and jejunostomy tubes placed for the delivery of a modified protein isolate diet. Following 7 days of postoperative depletion with a hypo-caloric infusion of dextrose (20 kcal, 0 g N/kg/day), the animals were repleted for 10 days with tube feedings (124 kcal, 0.73 g N/kg/day). There was no operative mortality or morbidity and each animal demonstrated conversion to anabolism by significant weight gain, positive nitrogen balance, and net protein synthesis as determined by [15N]glycine protein turnover rates. Significant correlation was found between caloric intake and nitrogen balance at the level of nitrogen provided in this diet (r = 0.88, p 0.05). This model was found to be well suited for the surgical and nutritional techniques required for the long-term study of enteral nutrition by tube.

Original languageEnglish (US)
Pages (from-to)34-38
Number of pages5
JournalJournal of Parenteral and Enteral Nutrition
Volume6
Issue number1
DOIs
StatePublished - Jan 1982
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Nutrition and Dietetics
  • Medicine (miscellaneous)

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